3-[3-(3-氨基丙酰氨基)丙酰氨基]丙酸 | 69010-59-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 3-[3-(3-氨基丙酰氨基)丙酰氨基]丙酸
• 英文名称: β-alanyl-β-alanyl-β-alanine
• 英文别名: β-Alaβ-Alaβ-Ala；Tri-β-alanin；(β-Alanyl)2-β-alanin；β-alanyl=>β-alanyl=>β-alanine；β-Alanyl=>β-alanyl=>β-alanin；H-beta-Ala-beta-ala-beta-ala-OH；3-[3-(3-aminopropanoylamino)propanoylamino]propanoic acid
• CAS: 69010-59-9
• 化学式: C₉H₁₇N₃O₄
• 分子量: 231.252
• InChiKey: INWKFTXYTDPZIX-UHFFFAOYSA-N

物化性质

• 熔点：
  194-195 °C(Solv: water (7732-18-5))
• 沸点：
  629.5±50.0 °C(Predicted)
• 密度：
  1.234±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -4.4
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  126
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-[3-(3-氨基丙酰氨基)丙酰氨基]丙酸 在 a-丙烯酸氯甲酯 、 三乙胺 作用下， 生成 cyclotri-β-alanyl
  参考文献：
  名称：

  White, David N. J.; Morrow, Christopher; Cox, Phillip J., Journal of the Chemical Society. Perkin transactions II, 1982, p. 239 - 244

  摘要：

  DOI：
• 作为产物：
  描述：

  benzyloxycarbonyl-β-alanyl-β-alanyl-β-alanine 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 、 溶剂黄146 为溶剂， 反应 8.0h， 以87.5%的产率得到3-[3-(3-氨基丙酰氨基)丙酰氨基]丙酸
  参考文献：
  名称：

  White, David N. J.; Morrow, Christopher; Cox, Phillip J., Journal of the Chemical Society. Perkin transactions II, 1982, p. 239 - 244

  摘要：

  DOI：

文献信息

• Synthesis of Orthogonally Protected Bis(aminomethyl)malonic Acid, and Its Use as a Key Building Block in the Preparation of Cyclic Peptide Conjugates of 2-N-Alkyl-1,2,3,4-tetrahydroisoquinoline on a Solid Support
  作者：Pasi Virta、Jaana Rosenberg、Tuomas Karskela、Petri Heinonen、Harri Lönnberg

  DOI：10.1002/1099-0690(200109)2001:18<3467::aid-ejoc3467>3.0.co;2-a

  日期：2001.9

  Orthogonally protected bis(aminomethyl)malonic acid (1) was synthesized and used as a key building block for the construction of cyclic peptide conjugates on a solid support. The applicability of the building block was demonstrated by preparation of 19 backbone cyclized/branched peptide conjugates of N-2-alkyl-5-(3-aminopropoxy)-1,2,3,4-tetrahydroisoquinoline as stereoisomeric pairs.

  合成了正交保护的双（氨基甲基）丙二酸（1），并用作在固体支持物上构建环肽缀合物的关键组成部分。通过制备N -2-烷基-5-（3-氨基丙氧基）-1,2,3,4-四氢异喹啉作为立体异构体对的19个骨架环化/支化的肽缀合物，证明了该结构单元的适用性。
• Adams; Davis; Smith, Journal of Biological Chemistry, 1952, vol. 199, p. 851
  作者：Adams、Davis、Smith

  DOI：——

  日期：——
• Measurement method using biosensor
  申请人：Ezoe Toshihide

  公开号：US20070020688A1

  公开（公告）日：2007-01-25

  It is an object of the present invention to provide a method for carrying out on a same biosensor both of the measurement of the amount of a physiologically active substance immobilized on a biosensor substrate and the measurement of the biological activity of the above physiologically active substance, thereby analyzing the interaction of a substance with the above physiologically active substance that maintains its activity. The present invention provides a measurement method using a biosensor substrate, wherein both the amount of a physiologically active substance immobilized on the substrate and the biological activity of the physiologically active substance immobilized on the substrate are measured on said same biosensor substrate.
• MASS LABELS
  申请人：Electrophoretics Limited

  公开号：US20150065392A1

  公开（公告）日：2015-03-05

  A reactive mass label for labelling a biological molecule for detection by mass spectrometry includes the following structure: X-L-M-S-Re, wherein X is a mass marker moiety, L is a cleavable linker, M is a mass normalization moiety, and S is a mass series modifying group including the following group: wherein J is C═O, K is NH, and n is 2 or J and K are both CH 2 and n is 1, m is at least 1; and Re is a reactive functionality for attaching the reactive mass label to a biological molecule.
• US7470549B2
  申请人：——

  公开号：US7470549B2

  公开（公告）日：2008-12-30