4-hydroxy-5-nitroindole | 135531-93-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 4-hydroxy-5-nitroindole
• 英文别名: 5-nitro-1H-indol-4-ol
• CAS: 135531-93-0
• 化学式: C₈H₆N₂O₃
• 分子量: 178.147
• InChiKey: MHEPDVIQGOXJAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  81.8
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-hydroxy-5-nitroindole 在 三乙基硅烷 、 间氯过氧苯甲酸 、 三氟乙酸 作用下， 生成 1,4-dihydroxy-5-nitroindole
  参考文献：
  名称：

  Preparations of 1-Hydroxyindole Derivatives and Their Potent Inhibitory Activities on Platelet Aggregation

  摘要：

  1-Hydroxymelatonin, 5-bromo- and 5,7-dibromo-1-hydroxytryptamine derivatives, 1,4-dihydroxy-5-nitroindole, 1-hydroxy-3-methylsulfinylmethylindole, and 5-acetyl-1,3,4,5-tetrahydro-1-hydroxypyrrolo[4,3,2-de]quinoline were synthesized for the first time, 1-Hydroxyindoles revealed potent inhibitory activities on platelet aggregation.

  DOI：

  10.3987/com-96-7537
• 作为产物：
  描述：

  (1-acetyl-3-formyl-5-nitroindol-4-yl) acetate 在 sodium hydroxide 、 sodium chloride 作用下， 生成 4-hydroxy-5-nitroindole
  参考文献：
  名称：

  Preparations of 1-Hydroxyindole Derivatives and Their Potent Inhibitory Activities on Platelet Aggregation

  摘要：

  1-Hydroxymelatonin, 5-bromo- and 5,7-dibromo-1-hydroxytryptamine derivatives, 1,4-dihydroxy-5-nitroindole, 1-hydroxy-3-methylsulfinylmethylindole, and 5-acetyl-1,3,4,5-tetrahydro-1-hydroxypyrrolo[4,3,2-de]quinoline were synthesized for the first time, 1-Hydroxyindoles revealed potent inhibitory activities on platelet aggregation.

  DOI：

  10.3987/com-96-7537

文献信息

• Hamabuchi, Shin; Hamada, Hirokazu; Hironaka, Akiko, Heterocycles, 1991, vol. 32, # 3, p. 443 - 448
  作者：Hamabuchi, Shin、Hamada, Hirokazu、Hironaka, Akiko、Somei, Masanori

  DOI：——

  日期：——
• Preparations of 1-Hydroxyindole Derivatives and Their Potent Inhibitory Activities on Platelet Aggregation
  作者：Masanori Somei、Koji Yamada、Masakazu Hasegawa、Mutsuko Tabata、Yoshiyuki Nagahama、Harunobu Morikawa、Fumio Yamada

  DOI：10.3987/com-96-7537

  日期：——

  1-Hydroxymelatonin, 5-bromo- and 5,7-dibromo-1-hydroxytryptamine derivatives, 1,4-dihydroxy-5-nitroindole, 1-hydroxy-3-methylsulfinylmethylindole, and 5-acetyl-1,3,4,5-tetrahydro-1-hydroxypyrrolo[4,3,2-de]quinoline were synthesized for the first time, 1-Hydroxyindoles revealed potent inhibitory activities on platelet aggregation.