Cinnamylchloracetat | 104023-33-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Cinnamylchloracetat
• 英文别名: Cinnamyl chloroacetate；3-phenylprop-2-enyl 2-chloroacetate
• CAS: 104023-33-8；104221-85-4
• 化学式: C₁₁H₁₁ClO₂
• 分子量: 210.66
• InChiKey: ZRCYVESZEBKTTA-UHFFFAOYSA-N

物化性质

• 沸点：
  335.6±30.0 °C(Predicted)
• 密度：
  1.181±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Cinnamylchloracetat 在 sodium acetate 、 tris(p-bromophenylammoniumyl) hexachloroantimonate 作用下， 以 乙腈 为溶剂， 反应 18.0h， 生成 7-methyl-9-phenylfuro[3,4-b]quinolin-3(1H)-one
  参考文献：
  名称：

  Catalytic Radical Cation Salt Induced C_sp³–H Functionalization of Glycine Derivatives: Synthesis of Substituted Quinolines

  摘要：

  A domino C-sp3-H functionalization of glycine derivatives was achieved under catalytic radical cation salt induced conditions, producing a series of quinolines. The proposed mechanism shows that a peroxyl radical cation, which is generated by the coupling between O-2 and TBPA(+center dot), might be involved to initiate the catalytic oxidation.

  DOI：

  10.1021/ol301909g
• 作为产物：
  描述：

  肉桂醇 、 氯乙酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 生成 Cinnamylchloracetat
  参考文献：
  名称：

  Catalytic Radical Cation Salt Induced C_sp³–H Functionalization of Glycine Derivatives: Synthesis of Substituted Quinolines

  摘要：

  A domino C-sp3-H functionalization of glycine derivatives was achieved under catalytic radical cation salt induced conditions, producing a series of quinolines. The proposed mechanism shows that a peroxyl radical cation, which is generated by the coupling between O-2 and TBPA(+center dot), might be involved to initiate the catalytic oxidation.

  DOI：

  10.1021/ol301909g

文献信息

• Enantioselective Allylic Thioetherification: The Effect of Phosphoric Acid Diester on Iridium‐Catalyzed Enantioconvergent Transformations
  作者：Markus Roggen、Erick M. Carreira

  DOI：10.1002/anie.201202092

  日期：2012.8.20

  You'll take the high road and I'll take the low road: Enantioenriched allylic thioethers have been synthesized from chiral racemic allylic alcohols. The combination of an Ir–(P,alkene) complex and dibutyl phosphoric acid are required to attain high selectivities. Mechanistic studies uncover an enantioconvergent transformation in which substrate enantiomers react along different pathways to give the

  你会走高端路线，我会走低价路线：对映体富集烯丙基硫醚已经从手性外消旋烯丙基醇合成。一个IR-（P，烯烃）复合物和二丁基磷酸的组合是必需的以获得高选择性。机理研究揭示了对映体会聚转化，其中底物对映异构体沿不同途径反应生成相同的产物（参见方案； cod = 1,5-环辛二烯）。
• B12 mimicry in a weak ligand environment: oxidation and alkylation of thiols
  作者：Shantanu Chowdhury、Purnima M. Samuel、Indira Das、Sujit Roy

  DOI：10.1039/c39940001993

  日期：——

  The first examples of alkylation and oxidation of thiols by cobalt in weakly coordinating ligand (MeCN) environment is presented as a mimic to B12-dependent nonenzymatic reaction.

  在弱配体（MeCN）环境中，用钴进行的硫醇烷基化和氧化的首个例子被呈现出来，作为B12依赖的非酶反应的模拟。
• Process for the preparation of alkenyl esters of acemetacin
  申请人：Bayer Aktiengesellschaft

  公开号：US04658039A1

  公开（公告）日：1987-04-14

  The new indole derivatives of the formula ##STR1## in which R.sup.1 and R.sup.2 are identical or different and denote hydrogen or lower alkyl, R.sup.3 denotes hydrogen, lower alkyl or halogen and R.sup.4 and R.sup.5 are identical or different and denote hydrogen, lower alkyl or optionally substituted aryl, and R.sup.4 and R.sup.5 can also represent lower alkenyl, and wherein R.sup.2 and R.sup.5 can be linked by an alkylene bridge of the formula --CH.sub.2 --CH.sub.2 --CH.sub.2).sub.n in which n represents the number 0 or 1, can be prepared by reacting an ammonium or phosphonium salt of the corresponding indolecarboxylic acid with a haloacetic acid allyl ester. The new compounds can be used to prepare acemetacin. The new indole derivatives possess a pharmacological action.

  新的吲哚衍生物的化学式为##STR1##，其中R.sup.1和R.sup.2相同或不同，表示氢或低碳基，R.sup.3表示氢，低碳基或卤素，R.sup.4和R.sup.5相同或不同，表示氢，低碳基或可选取代基苯基，R.sup.4和R.sup.5也可以表示低烯基，其中R.sup.2和R.sup.5可以通过化学式--CH.sub.2 --CH.sub.2 --CH.sub.2).sub.n的烷基桥连接，其中n表示数字0或1。这些新的化合物可以通过将相应的吲哚羧酸铵盐或磷酸铵盐与卤代乙酸烯丙酯反应制备而成。这些新化合物可用于制备乙酰美托酸。这些新的吲哚衍生物具有药理作用。
• RODENTICIDAL NORBORMIDE ANALOGUES
  申请人：Landcare Research New Zealand Limited

  公开号：US20150025113A1

  公开（公告）日：2015-01-22

  The present invention relates to norbormide analogues having rodenticidal activity; rodenticidal compositions comprising the analogues; uses of the analogues as rodenticides; uses of the analogues in the manufacture of rodenticidal compositions; and methods for controlling rodents using the compositions.

  本发明涉及具有杀鼠活性的诺博酰胺类似物；包含该类似物的杀鼠组合物；将该类似物用作杀鼠剂的用途；将该类似物用于制造杀鼠组合物的用途；以及使用该组合物控制啮齿动物的方法。
• Rodenticidal norbormide analogues
  申请人：Landcare Research New Zealand Limited

  公开号：US09198420B2

  公开（公告）日：2015-12-01

  The present invention relates to norbormide analogs having rodenticidal activity; rodenticidal compositions comprising the analogs; uses of the analogs as rodenticides; uses of the analogs in the manufacture of rodenticidal compositions; and methods for controlling rodents using the compositions.

  本发明涉及具有杀鼠活性的诺博酰胺类似物；包含该类似物的杀鼠组合物；将该类似物用作杀鼠剂的用途；将该类似物用于制造杀鼠组合物的用途；以及使用该组合物控制啮齿动物的方法。