3-bromo-4-(4-methoxyphenyl)-1-(triisopropylsilyl)pyrrole | 773851-40-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 3-bromo-4-(4-methoxyphenyl)-1-(triisopropylsilyl)pyrrole
• 英文别名: [3-bromo-4-(4-methoxyphenyl)pyrrol-1-yl]-tri(propan-2-yl)silane
• CAS: 773851-40-4
• 化学式: C₂₀H₃₀BrNOSi
• 分子量: 408.454
• InChiKey: DMZJZLDVNINFAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.95
• 重原子数：
  24.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  14.16
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  3-bromo-4-(4-methoxyphenyl)-1-(triisopropylsilyl)pyrrole 在 四丁基氟化铵 、 叔丁基锂 作用下， 以 四氢呋喃 为溶剂， 生成 4-(4-methoxyphenyl)-1H-pyrrole-3-carbaldehyde
  参考文献：
  名称：

  Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials

  摘要：

  A series of potential antimicrobial derivatives possessing bioisosteric replacements for the central oxazolidinone ring found in oxazolidinone antibacterials have been prepared. The design concept involved replacement of the requisite SP3-hybridized stereogenic center found at the 5-position of the oxazolidinone with a nitrogen atom. The synthesis and antibacterial activity of three such ring systems, the benzisoxazolinones, pyrroles, and isoxazolinones is described. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.06.076
• 作为产物：
  描述：

  N-(三异丙基甲硅烷基)-3,4-二溴吡咯 在 四(三苯基膦)钯 、 正丁基锂 作用下， 以 四氢呋喃 、 甲醇 、 甲苯 为溶剂， 生成 3-bromo-4-(4-methoxyphenyl)-1-(triisopropylsilyl)pyrrole
  参考文献：
  名称：

  Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials

  摘要：

  A series of potential antimicrobial derivatives possessing bioisosteric replacements for the central oxazolidinone ring found in oxazolidinone antibacterials have been prepared. The design concept involved replacement of the requisite SP3-hybridized stereogenic center found at the 5-position of the oxazolidinone with a nitrogen atom. The synthesis and antibacterial activity of three such ring systems, the benzisoxazolinones, pyrroles, and isoxazolinones is described. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.06.076

文献信息

• Synthesis of the pyrrolo[2,3-c]carbazole core of the dictyodendrins
  作者：Carles Ayats、Roger Soley、Fernando Albericio、Mercedes Álvarez

  DOI：10.1039/b822933n

  日期：——

  The pyrrolo[2,3-c]carbazole 1, the common core of the marine alkaloids known as the dictyodendrins, has been synthesised. The sequence is based on a Suzuki cross-coupling reaction between the pyrrole fragment 2 and the indole fragment 3, followed by tandem photochemical 6π-electrocyclisation/aromatisation.

  我们合成了吡咯并[2,3-c]咔唑 1，它是被称为二蝶荪类的海洋生物碱的共同核心。该序列基于吡咯片段 2 和吲哚片段 3 之间的铃木交叉偶联反应，然后进行串联光化学 6π 电环化/芳香化反应。
• Bumagin, N. A.; Nikitina, A. F.; Beletskaya, I. P., Russian Journal of Organic Chemistry, 1994, vol. 30, # 10, p. 1619 - 1629
  作者：Bumagin, N. A.、Nikitina, A. F.、Beletskaya, I. P.

  DOI：——

  日期：——