N,N-diethyl-N'-(4-methoxyphenyl)-1,2-ethanediamine | 89687-26-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N,N-diethyl-N'-(4-methoxyphenyl)-1,2-ethanediamine
• 英文别名: N--p-anisidin；N,N-diethyl-N'-(4-methoxy-phenyl)-ethylenediamine；N,N-Diaethyl-N'-(4-methoxy-phenyl)-aethylendiamin；1,2-Ethanediamine, N,N-diethyl-N'-(4-methoxyphenyl)-；N',N'-diethyl-N-(4-methoxyphenyl)ethane-1,2-diamine
• CAS: 89687-26-3
• 化学式: C₁₃H₂₂N₂O
• mdl: MFCD09035402
• 分子量: 222.33
• InChiKey: XUCODAYOWPYRCL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.538
• 拓扑面积：
  24.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N,N-diethyl-N'-(4-methoxyphenyl)-1,2-ethanediamine 在 盐酸 作用下， 生成 4-(2-diethylamino-ethylamino)-phenol
  参考文献：
  名称：

  Fourneau; de Lestrange, Bulletin de la Societe Chimique de France, 1947, p. 827,829,832

  摘要：

  DOI：
• 作为产物：
  描述：

  甲氧苯胺 、 N,N-二乙基氯乙胺 在 苯 作用下， 生成 N,N-diethyl-N'-(4-methoxyphenyl)-1,2-ethanediamine
  参考文献：
  名称：

  Fourneau; de Lestrange, Bulletin de la Societe Chimique de France, 1947, p. 827,829,832

  摘要：

  DOI：

文献信息

• Synthesis and cardiac electrophysiological activity of aryl-substituted derivatives of the class III antiarrhythmic agent sematilide. Potential class I/III agents
  作者：Gary B. Phillips、Thomas K. Morgan、Klaus Nickisch、Joan M. Lind、Robert P. Gomez、Ronald A. Wohl、Thomas M. Argentieri、Mark E. Sullivan

  DOI：10.1021/jm00164a025

  日期：1990.2

  Twelve novel derivatives of the selective class III antiarrhythmic agent sematilide were prepared in an attempt to incorporate both class I and class III electrophysiological properties into a single molecule. Electrophysiological activity was determined by standard microelectrode techniques in canine cardiac Purkinje fibers. Initial assessment of class I efficacy was carried out in a ouabain-induced arrhythmia model in guinea pigs. All of the compounds prolonged action potential duration in Purkinje fibers (class III activity), and three were active against ouabain-induced arrhythmias (class I activity). Selected compounds were evaluated further in dogs for efficacy against arrhythmias occurring 24 h following coronary ligation (automatic arrhythmias) and induced by using programmed electrical stimulation techniques (reentrant arrhythmias). The most effective compounds from the series are 3g and -j, which were effective in both canine models. Molecular modeling and structure-activity relationships are discussed.
• Dialkylaminoalkyl-diphenyl-acetanilides
  申请人：HOFFMANN LA ROCHE

  公开号：US02746992A1

  公开（公告）日：1956-05-22