6-[5-(tert-butyldimethylsilyloxy)-2-oxopentyl]-2,4-dimethoxy-3-methylbenzaldehyde | 606926-21-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-[5-(tert-butyldimethylsilyloxy)-2-oxopentyl]-2,4-dimethoxy-3-methylbenzaldehyde
• 英文别名: 6-[5-[Tert-butyl(dimethyl)silyl]oxy-2-oxopentyl]-2,4-dimethoxy-3-methylbenzaldehyde
• CAS: 606926-21-0
• 化学式: C₂₁H₃₄O₅Si
• 分子量: 394.583
• InChiKey: JXFLTGPNIZFJRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.74
• 重原子数：
  27
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6-[5-(tert-butyldimethylsilyloxy)-2-oxopentyl]-2,4-dimethoxy-3-methylbenzaldehyde 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 0.25h， 以86%的产率得到3-[2-(tert-butyldimethylsilyloxy)-ethyl]-5,7-dimethoxy-6-methylnaphthalen-2-ol
  参考文献：
  名称：

  A practical procedure for multisubstituted β-naphthols and their derivatives

  摘要：

  A number of multisubstituted beta-naphthols were efficiently prepared by intramolecular aldol condensation of readily available substituted benzyaldehydes, whose substituents were introduced easily by a selective alkylation on the benzylic position of the substrates. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(03)01066-4
• 作为产物：
  描述：

  2-(chloromethyl)-4,6-dimethoxy-benzaldehyde 在 正丁基锂 、 mercury(II) diacetate 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 甲醇 、 正己烷 、 水 、 丙酮 、 乙腈 为溶剂， 反应 13.08h， 生成 6-[5-(tert-butyldimethylsilyloxy)-2-oxopentyl]-2,4-dimethoxy-3-methylbenzaldehyde
  参考文献：
  名称：

  A practical procedure for multisubstituted β-naphthols and their derivatives

  摘要：

  A number of multisubstituted beta-naphthols were efficiently prepared by intramolecular aldol condensation of readily available substituted benzyaldehydes, whose substituents were introduced easily by a selective alkylation on the benzylic position of the substrates. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(03)01066-4

文献信息

• A practical procedure for multisubstituted β-naphthols and their derivatives
  作者：Wan-Guo Wei、Zhu-Jun Yao

  DOI：10.1016/s0040-4020(03)01066-4

  日期：2003.8

  A number of multisubstituted beta-naphthols were efficiently prepared by intramolecular aldol condensation of readily available substituted benzyaldehydes, whose substituents were introduced easily by a selective alkylation on the benzylic position of the substrates. (C) 2003 Elsevier Ltd. All rights reserved.