2-methoxymethyl-4-nitro-chlorobenzene | 101513-52-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methoxymethyl-4-nitro-chlorobenzene
• 英文别名: 1-chloro-2-methoxymethyl-4-nitro-benzene；4-nitro-2-methoxymethyl-chlorobenzene；1-Chloro-2-(methoxymethyl)-4-nitrobenzene
• CAS: 101513-52-4
• 化学式: C₈H₈ClNO₃
• mdl: MFCD11645996
• 分子量: 201.609
• InChiKey: DFVKPXXXKCFXAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-methoxymethyl-4-nitro-chlorobenzene 在 palladium 10% on activated carbon 、 四乙基溴化铵 氢气 、 magnesium sulfate 、 sodium sulfite 作用下， 以 乙醇 、 水 、 甲苯 为溶剂， 60.0~125.0 ℃ 、300.01 kPa 条件下， 反应 6.5h， 生成 2-methoxymethyl-1,4-benzenediamine malic acid
  参考文献：
  名称：

  [EN] METHODS OF SYNTHESIZING 2-METHOXYMETHYL-1,4-BENZENEDIAMINE
  [FR] PROCÉDÉS DE SYNTHÈSE DE 2-MÉTHOXYMÉTHYL-1,4-BENZÈNEDIAMINE

  摘要：

  揭示了一种制备2-甲氧甲基-1,4-苯二胺的方法，其中包括在氢化催化剂存在下氢化1-苄基氨基-2-(甲氧甲基)-4-硝基苯。

  公开号：

  WO2012044758A1
• 作为产物：
  描述：

  邻氯氯苄 在 硫酸 、 硝酸 作用下， 以 甲醇 为溶剂， 反应 1.0h， 生成 2-methoxymethyl-4-nitro-chlorobenzene
  参考文献：
  名称：

  [EN] METHODS OF SYNTHESIZING 2-METHOXYMETHYL-1,4-BENZENEDIAMINE
  [FR] PROCÉDÉS DE SYNTHÈSE DE 2-MÉTHOXYMÉTHYL-1,4-BENZÈNEDIAMINE

  摘要：

  揭示了一种制备2-甲氧甲基-1,4-苯二胺的方法，其中包括在氢化催化剂存在下氢化1-苄基氨基-2-(甲氧甲基)-4-硝基苯。

  公开号：

  WO2012044758A1

文献信息

• 2-OXO-2- (2-PHENYL-5,6,7,8-TETRAHYDRO-INDOLIZIN-3-YL) -ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ANTIFUNGAL AGENTS
  申请人：Payne Lloyd James

  公开号：US20110009390A1

  公开（公告）日：2011-01-13

  The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof: wherein: R1, R2, R3, R4, R5, R6, R7, R8, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in the manufacture of medicaments for use in the prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.

  该发明提供了式(I)的化合物，以及其在药学和农业上可接受的盐：其中：R1、R2、R3、R4、R5、R6、R7、R8、A1、L1和n如本文所定义。这些化合物及其药学上可接受的盐在制造用于预防或治疗真菌病的药物方面是有用的。式(I)的化合物及其在农业上可接受的盐也可用作农业杀菌剂。
• Substituted bis-(4-aminophenyl)-sulfones
  申请人：Dr. Karl Thomae GmbH

  公开号：US04829058A1

  公开（公告）日：1989-05-09

  Disclosed are substituted bis(4-aminophenyl)-sulfones of general formula ##STR1## wherein R.sub.1 is hydrogen, alkyl or cycloalkyl; group, R.sub.2 is hydrogen or C.sub.1 -C.sub.3 alkyl, R.sub.3 is nitrile, C.sub.1 -C.sub.3 alkylaminocarbonyl, di C.sub.1 -C.sub.3 alkylaminocarbonyl, C.sub.3 -C.sub.7 N-cycloalkyl-C.sub.1 -C.sub.3 alkylaminocarbonyl C.sub.1 -C.sub.3 alkylamino, C.sub.1 -C.sub.3, di alkylaminocarbonyl alkoxy, alkylaminosulfonyl, di C.sub.1 -C.sub.3 alkylaminono, diC.sub.1 -C.sub.3 alkylaminosulfonyl, hydroxy C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkylcarbonyl, amino C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy C.sub.1 -C.sub.3 alkyl group or, when R.sub.1 and R.sub.2 are each hydrogen, R.sub.3 can be hydroxy, hydroxycarbonyl C.sub.1 -C.sub.3 alkoxy or di C.sub.1 -C.sub.3 aminocarbonylalkoxy; or, when R.sub.1 is C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 cycloalkyl and R.sub.2 is hydrogen or C.sub.1 -C.sub.3 alkyl, R.sub.3 can also be halogen, trifluoromethyl, nitro, amino, aminosulfonyl, aminocarbonyl, C.sub.1 -C.sub.3 alkyl, carboxy or C.sub.1 -C.sub.3 alkoxycarbonyl; and R.sub.4 is hydrogen or, when R.sub.1 and R.sub.2 are each hydrogen and R.sub.3 is halogen or hydroxy, R.sub.4 can also be halogen, hydroxy or C.sub.1 -C.sub.3 alkoxy; or a nontoxic, pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions comprising such compounds alone and in combination with dihydrofolic acid-reductase inhibitors. The compounds and compositions are useful for their inhibiting effect on bacteria, mycobacteria and plasmodia.

  揭示了通式##STR1##中的取代双(4-氨基苯基)-砜，其中R.sub.1是氢、烷基或环烷基；基团，R.sub.2是氢或C.sub.1 -C.sub.3烷基，R.sub.3是腈基、C.sub.1 -C.sub.3烷基氨基甲酰基、二C.sub.1 -C.sub.3烷基氨基甲酰基、C.sub.3 -C.sub.7-N-环烷基-C.sub.1 -C.sub.3烷基氨基甲酰基、C.sub.1 -C.sub.3烷基氨基、C.sub.1 -C.sub.3，二烷基氨基甲酰基烷氧基、烷基氨基磺酰基、二C.sub.1 -C.sub.3烷基氨基磺酰基、羟基C.sub.1 -C.sub.3烷基、C.sub.1 -C.sub.3烷基羰基、氨基C.sub.1 -C.sub.3烷基或C.sub.1 -C.sub.3烷氧基烷基基团或者，当R.sub.1和R.sub.2分别为氢时，R.sub.3可以是羟基、羟基羰基C.sub.1 -C.sub.3烷氧基或二C.sub.1 -C.sub.3氨基甲酰氧基；或者，当R.sub.1为C.sub.1 -C.sub.3烷基或C.sub.1 -C.sub.3环烷基且R.sub.2为氢或C.sub.1 -C.sub.3烷基时，R.sub.3还可以是卤素、三氟甲基、硝基、氨基、氨基磺酰基、氨基甲酰基、C.sub.1 -C.sub.3烷基、羧基或C.sub.1 -C.sub.3烷氧羰基；以及R.sub.4是氢或者，当R.sub.1和R.sub.2分别为氢且R.sub.3为卤素或羟基时，R.sub.4还可以是卤素、羟基或C.sub.1 -C.sub.3烷氧基；或其无毒的、药学上可接受的盐。还揭示了包含这种化合物的药物组合物，单独使用或与二氢叶酸还原酶抑制剂结合。这些化合物和组合物对细菌、分枝杆菌和疟原虫的抑制作用很有用。
• Anti-bacterial compositions comprising a substituted
  申请人：Dr. Karl Thomae GmbH

  公开号：US05084449A1

  公开（公告）日：1992-01-28

  Disclosed are substituted bis(4-aminophenyl-sulfonees of general formula ##STR1## wherein R.sub.1 is hydrogen, alkyl or cycloalkyl; group, R.sub.2 is hydrogen or C.sub.1 -C.sub.3 alkyl, R.sub.3 is nitrile, C.sub.1 -C.sub.3 alkylaminocarbonyl, di C.sub.1 -C.sub.3 alkylaminocarbonyl, C.sub.3 -C.sub.7 N-cycloalkyl-C.sub.1 -C.sub.3 alkylaminocarbonyl C.sub.1 -C.sub.3 alkylamino, C.sub.1 -C.sub.3, di alkylaminocarbonyl alkoxy, alkylaminosulfonyl, di C.sub.1 -C.sub.3 alkylaminono, diC.sub.1 -C.sub.3 alkylaminosulfonyl, hydroxy C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkylcarbonyl, amino C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy C.sub.1 -C.sub.3 alkyl group or, when R.sub.1 and R.sub.2 are each hydrogen, R.sub.3 can be hydroxy, hydroxycarbonyl C.sub.1 -C.sub.3 alkoxy or di C.sub.1 -C.sub.3 aminocarbonylalkoxy; or, when R.sub.1 is C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 cycloalkyl and R.sub.2 is hydrogen or C.sub.1 -C.sub.3 alkyl, R.sub.3 can also be halogen, trifluoromethyl, nitro, amino, aminosulfonyl, aminocarbonyl, C.sub.1 -C.sub.3 alkylo, carboxy or C.sub.1 -C.sub.3 akoxycarbonyl; and R.sub.4 is hydrogen or, when R.sub.1 and R.sub.2 are each hydrogen and R.sub.3 is halogen or hydroxy, R.sub.4 can also be halogen, hydroxy or C.sub.1 -C.sub.3 alkoxy; or a nontoxic, pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions comprising such compounds alone and in combination with dihydrofolic acid-reductage inhibitors. The compounds and compositions are useful for their inhibiting effect on bacteria, mycobacteria and plasmodia.

  揭示了一种通用式为##STR1##的取代的双(4-氨基苯基-砜)化合物，其中R.sub.1是氢、烷基或环烷基；基团，R.sub.2是氢或C.sub.1-C.sub.3烷基，R.sub.3是腈、C.sub.1-C.sub.3烷基氨基羰基、二C.sub.1-C.sub.3烷基氨基羰基、C.sub.3-C.sub.7 N-环烷基-C.sub.1-C.sub.3烷基氨基羰基、C.sub.1-C.sub.3烷基氨基、C.sub.1-C.sub.3, 二烷基氨基羰基氧基、烷基氨基磺酰基、二C.sub.1-C.sub.3烷基氨基、二C.sub.1-C.sub.3烷基氨基磺酰基、羟基C.sub.1-C.sub.3烷基、C.sub.1-C.sub.3烷基羰基、氨基C.sub.1-C.sub.3烷基或C.sub.1-C.sub.3烷氧基烷基或，当R.sub.1和R.sub.2分别为氢时，R.sub.3可以是羟基、羟基羰基C.sub.1-C.sub.3烷氧基或二C.sub.1-C.sub.3氨基羰基氧基；或者，当R.sub.1为C.sub.1-C.sub.3烷基或C.sub.1-C.sub.3环烷基且R.sub.2为氢或C.sub.1-C.sub.3烷基时，R.sub.3也可以是卤素、三氟甲基、硝基、氨基磺酰基、氨基羰基、C.sub.1-C.sub.3烷氧、羧基或C.sub.1-C.sub.3氧羰基；而R.sub.4是氢或，当R.sub.1和R.sub.2分别为氢且R.sub.3为卤素或羟基时，R.sub.4也可以是卤素、羟基或C.sub.1-C.sub.3烷氧；或其无毒的、药学上可接受的盐。还揭示了包含这种化合物的药物组合物，单独使用或与二氢叶酸还原酶抑制剂结合。这些化合物和组合物对细菌、分枝杆菌和疟原虫的抑制作用具有用处。
• Lactam derivatives as antagonists for human 11cby receptors
  申请人：Armstrong Anne Sula

  公开号：US20050059651A1

  公开（公告）日：2005-03-17

  The invention provides compounds of formula (I) a salt, or solvate thereof.

  该发明提供了式(I)的化合物，其盐或溶剂。
• Novel Lactam Derivatives
  申请人：Armstrong Anne Sula

  公开号：US20060287321A1

  公开（公告）日：2006-12-21

  The invention thus provides compounds of formula (I) a salt, or solvate thereof.

  该发明因此提供了公式(I)的化合物，其盐或溶剂。