2,2,6,6-tetramethyl-4-(3',3',4',4',5',5',6',6',6'-nonafluorohexyl)-(3'',3'',4'',4'',5'',5'',6'',6'',6''-nonafluorohexan)amidepiperidin-1-oxyl | 1093628-39-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,2,6,6-tetramethyl-4-(3',3',4',4',5',5',6',6',6'-nonafluorohexyl)-(3'',3'',4'',4'',5'',5'',6'',6'',6''-nonafluorohexan)amidepiperidin-1-oxyl
• CAS: 1093628-39-7
• 化学式: C₂₁H₂₃F₁₈N₂O₂
• 分子量: 677.397
• InChiKey: NCWGYVPZAUMORZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  43
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  24.6
• 氢给体数：
  0
• 氢受体数：
  20

反应信息

• 作为反应物：
  描述：

  2,2,6,6-tetramethyl-4-(3',3',4',4',5',5',6',6',6'-nonafluorohexyl)-(3'',3'',4'',4'',5'',5'',6'',6'',6''-nonafluorohexan)amidepiperidin-1-oxyl 、 1,1'-偶氮(氰基环己烷) 以 甲苯 为溶剂， 反应 24.0h， 以97%的产率得到3',3',4',4',5',5',6',6',6'-nonafluorohexanoic acid [1-(1-cyanocyclohexyloxy)-2,2,6,6-tetramethylpiperidin-4-yl]-(3'',3'',4'',4'',5'',5'',6'',6'',6''-nonafluorohexyl)amide
  参考文献：
  名称：

  Light-fluorous TEMPO: reagent, spin trap and stable free radical

  摘要：

  The synthesis of two light-fluorous TEMPO derivatives is reported, along with their fluorous-organic solvent partition coefficients and their ESR spectra. Applications of the fluorous-TEMPO reagents in oxidation reactions and as radical traps are discussed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.04.078
• 作为产物：
  描述：

  2,2,6,6-tetramethyl-4-(3',3',4',4',5',5',6',6',6'-nonafluorohexylamino)piperidin-1-oxyl 、 3,3,4,4,5,5,6,6,6-九氟己酰氯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 3.25h， 以60%的产率得到2,2,6,6-tetramethyl-4-(3',3',4',4',5',5',6',6',6'-nonafluorohexyl)-(3'',3'',4'',4'',5'',5'',6'',6'',6''-nonafluorohexan)amidepiperidin-1-oxyl
  参考文献：
  名称：

  Light-fluorous TEMPO: reagent, spin trap and stable free radical

  摘要：

  The synthesis of two light-fluorous TEMPO derivatives is reported, along with their fluorous-organic solvent partition coefficients and their ESR spectra. Applications of the fluorous-TEMPO reagents in oxidation reactions and as radical traps are discussed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.04.078
• 作为试剂：
  描述：

  1,5-戊二醇 在 sodium hypochlorite 、 2,2,6,6-tetramethyl-4-(3',3',4',4',5',5',6',6',6'-nonafluorohexyl)-(3'',3'',4'',4'',5'',5'',6'',6'',6''-nonafluorohexan)amidepiperidin-1-oxyl 、 potassium bromide 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 delta-戊内酯
  参考文献：
  名称：

  Novel light-fluorous TEMPO reagents and their application in oxidation reactions

  摘要：

  The synthesis of two light-fluorous TEMPO derivatives is reported, along with their application in oxidation reactions. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.09.092

文献信息

• Novel light-fluorous TEMPO reagents and their application in oxidation reactions
  作者：Adrian P. Dobbs、Mark J. Penny、Peter Jones

  DOI：10.1016/j.tetlet.2008.09.092

  日期：2008.12

  The synthesis of two light-fluorous TEMPO derivatives is reported, along with their application in oxidation reactions. (C) 2008 Elsevier Ltd. All rights reserved.
• Light-fluorous TEMPO: reagent, spin trap and stable free radical
  作者：Adrian P. Dobbs、Peter Jones、Mark J. Penny、Stephen E. Rigby

  DOI：10.1016/j.tet.2009.04.078

  日期：2009.7

  The synthesis of two light-fluorous TEMPO derivatives is reported, along with their fluorous-organic solvent partition coefficients and their ESR spectra. Applications of the fluorous-TEMPO reagents in oxidation reactions and as radical traps are discussed. (C) 2009 Elsevier Ltd. All rights reserved.