3,3,4,4,5,5,6,6,6-九氟己酰氯 | 64018-24-2

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 中文名称: 3,3,4,4,5,5,6,6,6-九氟己酰氯
• 英文名称: 3,3,4,4,5,5,6,6,6-nonafluorohexanoyl chloride
• 英文别名: 2-perfluorobutyl ethanoyl chloride
• CAS: 64018-24-2
• 化学式: C₆H₂ClF₉O
• 分子量: 296.52
• InChiKey: OSYDIIQLLFZQKP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  10

安全信息

• 海关编码：
  2915900090

反应信息

• 作为反应物：
  描述：

  2,2,6,6-tetramethyl-4-(3',3',4',4',5',5',6',6',6'-nonafluorohexylamino)piperidin-1-oxyl 、 3,3,4,4,5,5,6,6,6-九氟己酰氯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 3.25h， 以60%的产率得到2,2,6,6-tetramethyl-4-(3',3',4',4',5',5',6',6',6'-nonafluorohexyl)-(3'',3'',4'',4'',5'',5'',6'',6'',6''-nonafluorohexan)amidepiperidin-1-oxyl
  参考文献：
  名称：

  Light-fluorous TEMPO: reagent, spin trap and stable free radical

  摘要：

  The synthesis of two light-fluorous TEMPO derivatives is reported, along with their fluorous-organic solvent partition coefficients and their ESR spectra. Applications of the fluorous-TEMPO reagents in oxidation reactions and as radical traps are discussed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.04.078
• 作为产物：
  描述：

  3,3,4,4,5,5,6,6,6-九氟己酸 在 氯化亚砜 作用下， 生成 3,3,4,4,5,5,6,6,6-九氟己酰氯
  参考文献：
  名称：

  Novel light-fluorous TEMPO reagents and their application in oxidation reactions

  摘要：

  The synthesis of two light-fluorous TEMPO derivatives is reported, along with their application in oxidation reactions. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.09.092

文献信息

• Fluoroalkyl surfactants
  申请人：Qiu Weiming

  公开号：US20090043130A1

  公开（公告）日：2009-02-12

  A compound of formula (I): wherein k is 1 or 2; Y is —CH 2 CH(CF 3 ) 2 or —(CH 2 ) n C F ; X is hydrogen, —(CH 2 ) n R f , or —C(O)[CF(A)] p -B—R f , wherein B is a divalent radical selected from the group consisting of a covalent bond, —O— and —(CH 2 ) m —; A is —F or —CF 3 ; and each R f is independently C 1 to C 6 perfluorinated linear or branched alkyl, optionally interrupted by one or more oxygens; R o is R o 1 or is a linear or branched alkyl having from about 10 to about 100 carbon atoms, interrupted or substituted by one or more hydrophilic groups selected from the group consisting of —O—, —OH, —NR—, —N(R) 2 , and —C(O)NR—, wherein a) the ratio of hydrophilic groups to carbon atoms is from about 1:2 to about 1:10; b) each carbon atom has at most one hydrophilic group bonded to it, and c) covalent bonding between hydrophilic groups is absent; R is hydrogen or a C 1 to C 4 linear or branched alkyl; and R o 1 is a linear or branched aliphatic group of from about 10 to about 100 carbon atoms, interrupted by about from about 5 to about 50 ether oxygens, wherein a) the ratio of ether oxygen to carbon atoms is from about 1:2 to about 1:3, b) each carbon atom has at most one ether oxygen atom bonded to it, and c) covalent bonding between ether oxygen atoms is absent; provided that 1) when Y is —(CH 2 ) n R f , R o is R o 1 ; 2) when X is hydrogen, Y is —CH 2 CH(CF 3 ) 2 ; and 3) when X is —(CH 2 ) n R f and Y is —(CH 2 ) n R f , R o is R o 1 .

  化合物式（I）：其中k为1或2；Y为—CH2CH（CF3）2或—（CH2）nCF；X为氢，—（CH2）nRf或—C（O）[CF（A）]p-B—Rf，其中B为从群组中选择的双价基团，该群组由共价键，—O—和—（CH2）m—组成；A为—F或—CF3；每个Rf独立地为C1到C6全氟线性或支链烷基，可选地由一个或多个氧原子中断；R为氢或C1到C4线性或支链烷基；Ro1为由约10到约100个碳原子组成的线性或支链烷基，由一个或多个亲水基团中断或取代，所述亲水基团从群组中选择，该群组由—O—，—OH，—NR—，—N（R）2和—C（O）NR—组成，其中a）亲水基团与碳原子的比率为约1:2至约1:10；b）每个碳原子最多只有一个与之相连的亲水基团；c）亲水基团之间的共价键缺失；Ro为Ro1或为由约10到约100个碳原子组成的线性或支链烷基，由约5到约50个醚氧原子中断，其中a）醚氧原子与碳原子的比率为约1:2至约1:3；b）每个碳原子最多只有一个与之相连的醚氧原子；c）醚氧原子之间的共价键缺失；前提是1）当Y为—（CH2）nRf时，Ro为Ro1；2）当X为氢时，Y为—CH2CH（CF3）2；3）当X为—（CH2）nRf且Y为—（CH2）nRf时，Ro为Ro1。
• Partially fluorinated compositions and surface active agents
  申请人：Acosta Erick Jose

  公开号：US20080113172A1

  公开（公告）日：2008-05-15

  Partially fluorinated amino acid derivatives are provided that are useful as organogelators and surface treatment materials to provide oil- and water-repellency properties to substrates. Also provided are composite materials comprising a porous support and a porous nanoweb. The porous nanoweb contains fibrous structures of about 10 nm to about 1000 nm effective average fiber diameter.

  提供部分氟化氨基酸衍生物，可用作有机凝胶剂和表面处理材料，以赋予基材油和水的抗性。还提供了复合材料，包括多孔支撑体和多孔纳米网。多孔纳米网包含有效平均纤维直径约为10纳米至1000纳米的纤维结构。
• Synthesis of 2H,2H-perfluoroalkyl and 2H-perfluoroalkenyl carboxylic acids and amides
  作者：Samuel Achilefu、Laurence Mansuy、Claude Selve、Sylvie Thiebaut

  DOI：10.1016/0022-1139(94)03084-d

  日期：1995.1

  An efficient and convenient procedure for the synthesis of 2-perfluoroalkyl ethanoic acids by direct oxidation of 2-perfluoroalkyl ethanols with Jones' reagent (CrO3/H2SO4) is described. Treatment of the acids with aqueous sodium hydroxide gave 3-perfluoroalkyl, 3-fluoro-2,3-propenyl carboxylic acids which may be used for the preparation of the corresponding chlorides and amides.
• FLUOROALKYL SURFACTANTS
  申请人：E. I. du Pont de Nemours and Company

  公开号：EP2173703B1

  公开（公告）日：2011-11-30
• US7638650B2
  申请人：——

  公开号：US7638650B2

  公开（公告）日：2009-12-29