galactonic acid | 3442-69-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: galactonic acid
• 英文别名: D-lyxo-3.4.5.6-tetrahydroxy-hexanoic acid；D-lyxo-3.4.5.6-Tetrahydroxy-hexansaeure；2-Desoxy-D-talonsaeure；2-Desoxy-D-galaktonsaeure；'d-Galaktoorthosaccharinsaeure'；2-Deoxy-D-lyxo-hexonic acid；(3R,4R,5R)-3,4,5,6-tetrahydroxyhexanoic acid
• CAS: 3442-69-1；5729-75-9；6477-49-2；16722-47-7；26234-81-1；79434-10-9；16867-64-4
• 化学式: C₆H₁₂O₆
• 分子量: 180.158
• InChiKey: PALQXFMLVVWXFD-ZMIZWQJLSA-N

物化性质

• 沸点：
  556.8±50.0 °C(Predicted)
• 密度：
  1.589±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  118
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (2R,3R,4R)-2-(羟基甲基)-3,4-二氢-2H-吡喃-3,4-二醇 在 3,5-二硝基水杨酸 、 lithium bromide 作用下， 反应 0.25h， 生成 galactonic acid
  参考文献：
  名称：

  Substrate specificity of galactokinase from Streptococcus pneumoniae TIGR4 towards galactose, glucose, and their derivatives

  摘要：

  Galactokinases (GalKs) have attracted significant research attention for their potential applications in the enzymatic synthesis of unique sugar phosphates. The galactokinase (GalKSpe4) cloned from Streptococcus pneumoniae TIGR4 presents a remarkably broad substrate range including 14 diverse natural and unnatural sugars. TLC and MS studies revealed that GalKSpe4 had relaxed activity towards galactose derivatives with modifications on the C-6, 4- or 2-positions. Additionally, GalKSpe4 can also tolerate glucose while glucose derivatives with modifications on the C-6, 4- or 2-positions were unacceptable. More interestingly, GalKSpe4 can phosphorylate L-mannose in moderate yield (43%), while other L-sugars such as L-Gal cannot be recognized by this enzyme. These results are very significant because there is rarely enzyme reported that can phosphorylate such uncommon substrates as L-mannose. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.03.095

文献信息

• Catalytic dehydrogenation of reducing sugars in alkaline solution
  作者：Gert de Wit、Jan J. de Vlieger、Alida C. Kock-van Dalen、Roelf Heus、Rob Laroy、Antonius J. van Hengstum、Antonius P.G. Kieboom、Herman van Bekkum

  DOI：10.1016/s0008-6215(00)86025-5

  日期：1981.5

  Abstract Aldoses in alkaline medium under the catalytic action of platinum or rhodium are converted into aldonic acids with high selectivity and with concomitant evolution of hydrogen gas. The dehydrogenation reaction has been studied for 25 different mono- and di-saccharides, and is generally applicable for reducing sugars. The influence of several reaction variables has been studied, leading to an

  摘要碱性介质中的醛类在铂或铑的催化作用下被高选择性地转化为醛糖酸，并伴随着氢气的逸出。已经针对25种不同的单糖和二糖研究了脱氢反应，该反应通常可用于还原糖。研究了几个反应变量的影响，得出了一个吸附模型，在该模型中，带负电荷的O-1和H-1与催化剂表面的紧密接触均被视为推动氢化物从C-转移的动力。将1的糖加入催化剂中。
• Microorganisms and methods for the co-production of ethylene glycol and three carbon compounds
  申请人：Braskem S.A.

  公开号：US10774348B2

  公开（公告）日：2020-09-15

  The present application relates to recombinant microorganisms useful in the biosynthesis of monoethylene glycol (MEG) and one or more three-carbon compounds such as acetone, isopropanol or propene. The MEG and one or more three-carbon compounds described herein are useful as starting material for production of other compounds or as end products for industrial and household use. The application further relates to recombinant microorganisms co-expressing a C2 branch pathway and a C3 branch pathway for the production of MEG and one or more three-carbon compounds. Also provided are methods of producing MEG and one or more three-carbon compounds using the recombinant microorganisms, as well as compositions comprising the recombinant microorganisms and/or optionally the products MEG and one or more three-carbon compounds.

  本申请涉及用于生物合成单乙二醇（MEG）和一种或多种三碳化合物（如丙酮、异丙醇或丙烯）的重组微生物。本文所述的 MEG 和一种或多种三碳化合物可用作生产其他化合物的起始原料，或用作工业和家用的最终产品。本申请还涉及共表达 C2 分支途径和 C3 分支途径的重组微生物，用于生产 MEG 和一种或多种三碳化合物。本申请还提供了使用重组微生物生产 MEG 和一种或多种三碳化合物的方法，以及包含重组微生物和/或可选产物 MEG 和一种或多种三碳化合物的组合物。
• Gachokidse, Zhurnal Obshchei Khimii, 1940, vol. 10, p. 507,508, 509
  作者：Gachokidse

  DOI：——

  日期：——
• MICROORGANISMS AND METHODS FOR THE CO-PRODUCTION OF ETHYLENE GLYCOL AND THREE CARBON COMPOUNDS
  申请人：Braskem S.A.

  公开号：US20170260551A1

  公开（公告）日：2017-09-14

  The present application relates to recombinant microorganisms useful in the biosynthesis of monoethylene glycol (MEG) and one or more three-carbon compounds such as acetone, isopropanol or propene. The MEG and one or more three-carbon compounds described herein are useful as starting material for production of other compounds or as end products for industrial and household use. The application further relates to recombinant microorganisms co-expressing a C2 branch pathway and a C3 branch pathway for the production of MEG and one or more three-carbon compounds. Also provided are methods of producing MEG and one or more three-carbon compounds using the recombinant microorganisms, as well as compositions comprising the recombinant microorganisms and/or optionally the products MEG and one or more three-carbon compounds.