bis(α-carbomethoxyethyl)disulfide | 41145-55-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: bis(α-carbomethoxyethyl)disulfide
• 英文别名: dimethyl dithiodipropionate；2,2'-Dithiodipropionic acid dimethyl ester；methyl 2-[(1-methoxy-1-oxopropan-2-yl)disulfanyl]propanoate
• CAS: 41145-55-5
• 化学式: C₈H₁₄O₄S₂
• 分子量: 238.329
• InChiKey: OUSFYNFYPKAEEY-UHFFFAOYSA-N

物化性质

• 熔点：
  154 °C
• 沸点：
  284.7±25.0 °C(Predicted)
• 密度：
  1.214±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  103
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  methyl 2-(acetylsulfanyl)propionate 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 4.0h， 生成 bis(α-carbomethoxyethyl)disulfide 、 2-巯基丙酸甲酯
  参考文献：
  名称：

  通过原子转移自由基聚合合成的（甲基）丙烯酸聚合物中的溴端基向硫醇的转化

  摘要：

  通过原子转移自由基聚合（ATRP）制备的聚合物的卤素端基可以通过不同的化学修饰转化为其他官能团。在本文中，首次报道了通过ATRP合成的在（甲基）丙烯酸类聚合物中将溴端基改性为硫醇官能度的新方法。因此，几种聚（甲基丙烯酸甲酯）的溴端基被成功地转化为硫代乙酸酯，然后通过受控的水解转化为巯基。为此官能化证实引入原位通过硫醇-烯荧光基团“点击”用合成alquene反应拴在4,4-二氟-4-硼-3-一个，4一-diaza-小号-茚并二烯（BODIPY）片段。此外，将溴化ATRP引发剂转化为新的硫醇官能化分子的两个模型反应证明，该方法可应用于ATRP合成的甲基丙烯酸或丙烯酸聚合物。

  DOI：

  10.1021/ma102829s

文献信息

• Additives for lubricating oils and fuel oils, lubricating oil compositions, and fuel oil compositions
  申请人：Shimizu Nobuaki

  公开号：US20060148663A1

  公开（公告）日：2006-07-06

  Additives for lubricating oils and for fuel oils which comprise as the main component a disulfide represented by the following general formula (I) or (IV): R 1 OOC-A 1 -S x -A 2 -COOR 2 (I) (R 1 and R 2 each independently represent a hydrocarbyl group which has 1 to 30 carbon atoms and may have oxygen atom, sulfur atom or nitrogen atom, A 1 and A 2 each independently represent a group represented by CR 3 R 4 , R 3 and R 4 each independently representing hydrogen atom or a hydrocarbyl group having 1 to 20 carbon atoms, and x represents 2.) R 1 OOC-A 3 -S x -A 4 -COOR 2 (IV) (R 1 and R 2 are as defined above, A 3 and A 4 each independently represent a group represented by CR 5 R 6 —CR 7 R 8 , R 5 to R 8 each independently representing hydrogen atom or a hydrocarbyl group having 1 to 20 carbon atoms, and x represents 2.) The additives exhibit excellent functions as the extreme pressure additive and the antiwear agent and the suppressed corrosive property to nonferrous metals and are advantageously used as the sulfur-based extreme pressure additives for lubricating oils and fuel oils.

  润滑油和燃料油的添加剂包括以下通式（I）或（IV）所表示的二硫化物作为主要成分： R1OOC-A1-Sx-A2-COOR2（I）（其中，R1和R2分别独立地表示具有1至30个碳原子且可能具有氧原子、硫原子或氮原子的烃基，A1和A2分别独立地表示CR3R4所表示的基团，R3和R4分别独立地表示氢原子或具有1至20个碳原子的烃基，x表示2。） R1OOC-A3-Sx-A4-COOR2（IV）（其中，R1和R2如上定义，A3和A4分别独立地表示CR5R6-CR7R8所表示的基团，R5至R8分别独立地表示氢原子或具有1至20个碳原子的烃基，x表示2。） 这些添加剂表现出极压添加剂和抗磨剂的优异功能，对非铁质金属具有抑制腐蚀性能，是用于润滑油和燃料油的硫基极压添加剂的有利选择。
• Process for the removal of hydrogen sulfide and optionally carbon dioxide from gaseous streams
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0279667A2

  公开（公告）日：1988-08-24

  Hydrogen sulfide and/or carbon dioxide are removed from a sour gaseous stream in a contact zone by contacting the sour gaseous stream with H₂S- and/or CO₂- selective absorbent in an aqueous alkaline solution containing a polyvalent metal chelate at a pH of 7 to 10 wherein polyvalent metal chelate is in one embodiment of the invention in the reduced or lower valence state in a contact zone and is oxidized to the oxidized or higher valence state in an oxidation zone so as to convert hydrosulfide and/or sulfide salts present in the contact zone to sulfur. In a second embodiment, the aqueous alkaline solution and H₂S- and/or CO₂- selective absorbent in contact with the gaseous stream is a mixture containing a higher valence polyvalent metal chelate together with a lower valence polyvalent metal chelate, which lower valence polyvalent metal chelate is present in at least about five times the amount of the higher valence polyvalent metal chelant.

  硫化氢和/或二氧化碳从接触区的酸气流中去除，方法是将酸气流与 H₂S- 和/或 CO₂-在本发明的一个实施方案中，多价金属螯合物在接触区处于还原态或低价态，在氧化区被氧化为氧化态或高价态，从而将接触区中存在的硫化氢和/或硫化物盐转化为硫。在第二个实施方案中，与气态流接触的碱性水溶液和 H₂S- 和/或 CO₂- 选择性吸收剂是一种混合物，其中含有高价多价金属螯合物和低价多价金属螯合物，低价多价金属螯合物的含量至少约为高价多价金属螯合物的五倍。
• Leukotriene antagonist prodrugs
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP0365149A2

  公开（公告）日：1990-04-25

  A compound represented by the following structural formula (I): wherein (a) R₁ is C₈ to C₁₃ alkyl, C₇ to C₁₂ alkoxy, C₇ to C₁₂ alkylthio, C₁₀ to C₁₂ 1-alkynyl, 10-undecynyloxy, 11-­dodecynyl, phenyl-C₄ to C₁₀ alkyl, phenyl-C₃ to C₉ alkoxy, phenylthio-C₃ to C₉ alkyl with the phenyl optionally mono substituted with bromo, chloro, trifluoromethyl, alkoxy, methylthio or trifluoromethylthio, thienyl-C₄ to C₁₀ alkyl furyl-C₄ to C₁₀ alkyl,trifluoromethyl-C₇ to C₁₂ alkyl or cycloheyl-C₄ to C₁₀ alkyl; and     R₂ is hydrogen, bromo, chloro, methyl, trifluoromethyl, hydroxy, alkoxy or nitro; (b) or R₁ is hydrogen and R₂ is C₈ to C₁₃ alkyl, C₇ to C₁₂ alkoxy, C₇ to C₁₂ alkylthio, C₁₀ to C₁₂ 1-alkynyl, 10-­undecynyloxy, 11-dodecynyl, phenyl-C₄ to C₁₀ alkyl, phenyl-C₃ to C₉ alkoxy, phenylthio-C₃ to C₉ alkyl with the phenyl optionally mono substituted with bromo, chloro, trifluoro­methyl, alkoxy, methylthio or trifluoromethylthio, furyl-C₄ to C₁₀ alkyl, trifluoromethyl-C₇ to C₁₂ alkyl or cyclohexyl-C₄ to C₁₀ alkyl;     q is 0, 1, or 2;     Y is COR₃, CH(R₄)(CH₂)mCOR₃ or CH(R₄)(CH₂)m-­tetrazol-5-yl the tetrazol-5-yl being unsubstituted or substituted with A;     R₁₆ and R₁₇ are independently hydrogen or C₁₋₄ alkyl;     j is 0 to 6;     R₁₈ is hydrogen, alkyl, COR₃, SO₃H, SO₂NH₂, COCH₂OH or CHOHCH₂OH;     R₃ is amino, (CH₂)nCO₂CH₂CONR₁₆R₁₇, or OR₁₄;     R₁₄ is hydrogen, alkyl, cycloalkyl, aryl, arylalkyl, alkylaryl, alkylarylalkyl, alkyl substituted amino or alkylamino, - OCH₂CONR₇R₈, indanyl, pivaloyloxymethyl, acetoxymethyl, propionyloxymethyl, glycyloxymethyl, phenylglycyloxymethyl, or thienylglycyloxymethyl;     R₄ is hydrogen, methyl, alkoxy, fluoro or hydroxy;     m is 0, or 1;     R is (CH₂)nCOR₆, CH(CO₂H)CH₂COR₆, (CH₂)nCO₂CH₂CONR₁₆,R₁₇, or an imidazole of the formula     n is 0 to 6;     R₅ is hydrogen, amino, or NHCOCH₂CH₂CH(NH₂)CO₂H;     R₆ is amino, NH(CH₂)nCO₂H, SO₃H, SO₂NH₂, CN, tetrazol-5-yl unsubstituted or substituted with A as defined above, or OR₁₅;     R₇ is hydrogen, alkyl or alkenyl;     R₈ is hydrogen, alkyl, carboxyl or carboxamido, or, when R₇ and R₉ are hydrogen or alkyl, (CH₂)mCOOR₁₅;     R₉ is hydrogen, alkyl or (CH₂)mCOOR₁₅;     R₁₅ is hydrogen, alkyl, cycloalkyl, aryl, arylalkyl, alkylaryl, alkylarylalkyl, allayl substituted amino or alkylamino, -OCH₂CONR₇R₈, indanyl, pivaloyloxymethyl, acetoxymethyl, propionyloxymethyl, glycyloxymethyl, phenylglycyloxymethyl, or thienylglycyloxymethyl;     provided that 1) when n is 0, R₅ is hydrogen, 2) R₇, R₈ and R₉ are not all hydrogen, 3) any of R₁and R₂ above are not alkylthio or phenylthioalkyl when q is 1 or 2, 4) R₃ and R₆ are not both hydroxy, 5) OR₁₄ and OR₁₅ are not simultaneously hydroxy; 6) if R₄ is hydroxy and m is 0, R₁₄ is hydrogen; or     a pharmaceutically acceptable salt thereof.

  由以下结构式(I)代表的化合物： 其中 (a) R₁ 是 C₈ 至 C₁₃ 烷基、C₇ 至 C₁₂ 烷氧基、C₇ 至 C₁₂ 烷硫基、C₁₀ 至 C₁₂ 1-炔基、10-十一炔氧基、11-十二炔基、苯基-C₄ 至 C₁₀ 烷基、苯基-C₃ 至 C₉ 烷氧基、苯硫基-C₃至 C₉烷基，其中苯基可选择被溴、氯、三氟甲基、烷氧基、甲硫基或三氟甲硫基单取代、噻吩基-C₄至 C₁₀ 烷基 呋喃基-C₄至 C₁₀ 烷基、三氟甲基-C₇至 C₁₂ 烷基或环己基-C₄至 C₁₀ 烷基；和 R₂ 是氢、溴、氯、甲基、三氟甲基、羟基、烷氧基或硝基； (b) 或 R₁ 是氢且 R₂ 是 C₈ 至 C₁₃ 烷基、C₇ 至 C₁₂ 烷氧基、C₇ 至 C₁₂ 烷硫基、C₁₀ 至 C₁₂ 1-炔基、10-十一炔氧基、11-十二炔基、苯基-C₄ 至 C₁₀ 烷基、苯基-C₃ 至 C₉ 烷氧基、苯硫基-C₃-C₉烷基，其中苯基可选择被溴、氯、三氟甲基、烷氧基、甲硫基或三氟甲基单取代、C₄至 C₁₀ 烷基、三氟甲基-C₇至 C₁₂ 烷基或环己基-C₄至 C₁₀ 烷基； q 是 0、1 或 2； Y 是 COR₃、CH(R₄)(CH₂)mCOR₃ 或 CH(R₄)(CH₂)m-四唑-5-基，四唑-5-基未被 A 取代或被 A 取代；R₁₆ 和 R₁₇ 独立地是氢或 C₁₋₄ 烷基； j 为 0 至 6； R₁₈ 是氢、烷基、COR₃、SO₃H、SO₂NH₂、COCH₂OH 或 CHOHCH₂OH； R₃ 是氨基、(CH₂)nCO₂CH₂CONR₁₆R₁₇ 或 OR₁₄； R₁₄ 是氢、烷基、环烷基、芳基、芳烷基、烷芳基、烷芳基烷基、烷基取代的氨基或烷基氨基、- OCH₂CONR₇R₈、茚基、新戊酰氧基甲基、乙酰氧基甲基、丙酰氧基甲基、甘氨酰氧基甲基、苯基甘氨酰氧基甲基或噻吩基甘氨酰氧基甲基； R₄ 是氢、甲基、烷氧基、氟或羟基； m 为 0 或 1； R 是 (CH₂)nCOR₆、CH(CO₂H)CH₂COR₆、 (CH₂)nCO₂CH₂CONR₁₆ 、R₁₇ 或式 n 为 0 至 6 的咪唑； R₅ 是氢、氨基或 NHCOCH₂CH₂CH(NH₂)CO₂H； R₆ 是氨基、NH(CH₂)nCO₂H、SO₃H、SO₂NH₂、CN、未取代或被如上定义的 A 取代的四唑-5-基，或 OR₁₅； R₇ 是氢、烷基或烯基； R₈ 是氢、烷基、羧基或羧酰胺基，或 当 R₇ 和 R₉ 是氢或烷基时，(CH₂)mCOOR₁₅； R₇ 和 R₉ 是氢或烷基、(CH₂)mCOOR₁₅； R₁₅是氢、烷基、环烷基、芳基、芳烷基、烷芳基、烷芳基烷基、被异丙基取代的氨基或烷基氨基、-OCH₂CONR₇R₈、茚基、新戊酰氧基甲基、乙酰氧基甲基、丙酰氧基甲基、甘氨酰氧基甲基、苯基甘氨酰氧基甲基或噻吩基甘氨酰氧基甲基； 条件是：1）当 n 为 0 时，R₅ 为氢；2）R₇、R₈ 和 R𠢙 并非都是氢、3) 当 q 为 1 或 2 时，上述 R₁ 和 R₂ 中的任一个不是烷硫基或苯硫烷基， 4) R₃ 和 R₆ 不是同时为羟基， 5) OR₁₄ 和 OR₁₅ 不是同时为羟基；6) 如果 R₄ 是羟基且 m 是 0，则 R₁₄ 是氢；或 其药学上可接受的盐。
• Method for preparing mercaptopropionic acid esters
  申请人：WITCO CORPORATION

  公开号：EP0485139A1

  公开（公告）日：1992-05-13

  A process is provided for the preparation of mercaptopropionic acid esters by reaction of an acrylic acid ester with hydrogen sulfide in the presence of a weakly basic amine as a catalyst, a polyether as a co-catalyst, a polythiodipropionic acid ester as a reactive solvent, and added elemental sulfur.

  本发明提供了一种制备巯基丙酸酯的工艺，该工艺是在弱碱性胺作为催化剂、聚醚作为助催化剂、聚硫二丙酸酯作为反应溶剂以及添加元素硫的存在下，通过丙烯酸酯与硫化氢的反应制备巯基丙酸酯。
• Thioester polymerization modifiers
  申请人：WITCO CORPORATION

  公开号：EP0507602A1

  公开（公告）日：1992-10-07

  A composition and method for the polymerization of polymerizable resins which undergo exothermic polymerization, including unsaturated polyester resins, vinyl ester resins and mixtures thereof, and the polymerized product thereof, wherein an ester of a thiocarboxylic acid is present in a effective amount to substantially reduce the exothermic heat generated during polymerization of the resin, but insufficient to substantially affect the degree or rate of polymerization of the resin. The preferred thioester has the formula in which Z is an alkyl having 1-18 carbon atoms or a is 1 or 2, b is a whole number from 1 to about 5, n is a whole number from zero to b, and R is an alkyl or hydroxyalkyl having 1 - 18 carbon atoms and zero to 2 hydroxyl groups, alkyloxyethyl, alkyloxyethoxyethyl, and alkyloxypolyethoxyethyl having 1 to about 30 carbon atoms in the alkyl group; or when n is zero and Z is alkyl, R is in which Y is an alkylene group having 2 to about 20 carbon atoms or an alkylene group interrupted at intervals of 2 or more carbon atom by oxygen atoms and having 4 to about 40 carbon atoms and one to 19 oxygen atoms. Preferred specific thioesters include ditridecyl thiodipropionate, dimethyl thiodipropionate, and dimethyl dithiodipropionate. The thioesters also function as resist agents against thermal oxidation, wetting and air release agents, synergists for thermal oxidation resist agents and ultraviolet and light stabilizing agents, stabilizers for the resins and they reduce the volatilization of styrene monomers during the polymerization.

  一种用于聚合放热的可聚合树脂（包括不饱和聚酯树脂、乙烯基酯树脂及其混合物）及其聚合产物的组合物和方法，其中硫代羧酸酯的有效含量可大大减少树脂聚合过程中产生的放热，但不足以大大影响树脂的聚合度或聚合速率。优选的硫代酯类分子式为 其中 Z 是具有 1-18 个碳原子的烷基或 a 是 1 或 2，b 是 1 至约 5 的整数，n 是 0 至 b 的整数，R 是具有 1-18 个碳原子和 0 至 2 个羟基的烷基或羟基烷基，烷基中具有 1 至约 30 个碳原子的烷氧基乙基、烷氧基乙氧基乙基和烷氧基聚乙氧基乙基；或当 n 为零且 Z 是烷基时，R 是 其中 Y 是具有 2 至约 20 个碳原子的亚烷基，或以 2 个或更多碳原子为间隔被氧原子打断的亚烷基，具有 4 至约 40 个碳原子和 1 至 19 个氧原子。优选的特定硫代酯类包括硫代二丙酸双十三烷基酯、硫代二丙酸二甲酯和二硫代二丙酸二甲酯。硫代酯还可用作抗热氧化剂、润湿剂和脱气剂、抗热氧化剂和紫外线及光稳定剂的增效剂、树脂的稳定剂，并可减少苯乙烯单体在聚合过程中的挥发。