diethyl 5-methylpyrrole-2,3-dicarboxylate | 91248-33-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: diethyl 5-methylpyrrole-2,3-dicarboxylate
• 英文别名: 5-methyl-pyrrole-2,3-dicarboxylic acid diethyl ester；5-Methyl-pyrrol-2,3-dicarbonsaeure-diaethylester；diethyl 5-methyl-1H-pyrrole-2,3-dicarboxylate
• CAS: 91248-33-8
• 化学式: C₁₁H₁₅NO₄
• 分子量: 225.244
• InChiKey: APERLAAAUZOLPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  68.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  diethyl 5-methylpyrrole-2,3-dicarboxylate 在 氢氧化钾 、 potassium permanganate 、 N,N-二甲基甲酰胺 、 丙酮 、 三氯氧磷 作用下， 生成 2-methylpyrrole-3,4,5-tricarboxylic acid
  参考文献：
  名称：

  Nicolaus; Mangoni, Annali di Chimica, 1956, vol. 46, p. 847,854

  摘要：

  DOI：
• 作为产物：
  描述：

  acetonyl-oxalacetic acid diethyl ester 在 乙醚 、 乙醇 、 氨 作用下， 生成 diethyl 5-methylpyrrole-2,3-dicarboxylate
  参考文献：
  名称：

  2,3-Furan, Pyrrole and Thiophenedicarboxylic Acids

  摘要：

  DOI：

  10.1021/ja01620a031

文献信息

• Emotional Change Processes in Music-Assisted Reframing
  作者：T. Kerr、J. Walsh、A. Marshall

  DOI：10.1093/jmt/38.3.193

  日期：2001.9.1

  Affective processes are critical to understanding and promoting lasting therapeutic change. Using a sample of 40 anxious adults, the researchers examined the use of music to increase affective modification and emotional restructuring in a cognitive reframing intervention. Subjects were assigned to either a typical reframing intervention or a music-assisted reframing intervention. Using the State-Trait Anxiety Inventory, Subjective Units of Distress Scale, Depression Adjective Checklist, and a Think-Aloud measure, the groups were compared on basis of anxiety-reduction, affective modification, and imagery vividness. Results indicate that the music-assisted reframing intervention was more efficacious than the typical reframing intervention in reducing anxiety, modifying affect, and promoting imagery-vividness.

  情感过程对理解和促进持久的治疗变化至关重要。研究人员使用40名焦虑成年人的样本，考察了音乐在认知重构干预中提高情感修正和情绪重组的作用。受试者被分配到典型的重构干预或音乐辅助重构干预组。使用状态-特质焦虑量表、主观痛苦单位量表、抑郁形容词清单和思维大声测量，对两组在焦虑减少、情感修正和意象生动性方面进行了比较。结果表明，音乐辅助重构干预在减少焦虑、修正情感和促进意象生动性方面比典型的重构干预更有效。
• Synthesis and biological evaluation of pyrrolopyridazine derivatives as novel HER-2 tyrosine kinase inhibitors
  作者：Peng Cho Tang、Jun Feng、Li Huang、Zhe Xu、Ling Cheng、Xu Zhang、Lei Zhang、Bing Hu

  DOI：10.1016/j.bmcl.2009.09.038

  日期：2009.11

  A series of novel pyrrolopyridazine derivatives have been discovered to be HER-2 inhibitors. These compounds selectively inhibited HER-2 kinase activity at low nanomolar concentrations. Compound 7d was identified as a potent HER-2 inhibitor with an IC50 of 4 nM.

  已经发现一系列新的吡咯并哒嗪衍生物是HER-2抑制剂。这些化合物在低纳摩尔浓度下选择性抑制HER-2激酶活性。化合物7d被鉴定为有效的HER-2抑制剂，IC 50为4 nM。
• 2,3-Furan, Pyrrole and Thiophenedicarboxylic Acids
  作者：Reuben G. Jones

  DOI：10.1021/ja01620a031

  日期：1955.8
• Rhodium Complex-Catalyzed Reaction of Isonitriles with Carbonyl Compounds:  Catalytic Synthesis of Pyrroles
  作者：Hikaru Takaya、Sachiko Kojima、Shun-Ichi Murahashi

  DOI：10.1021/ol0069296

  日期：2001.2.1

  [GRAPHICS]Low-valent rhodium complexes are efficient catalysts for the activation of alpha -C-H bond of isonitriles. Addition of isonitriles to carbonyl compounds proceeds under mild and neutral conditions to give the corresponding alpha,beta -unsaturated formamides. Catalytic synthesis of pyrroles can be performed by cyclocondensation of isonitriles with 1,3-dicarbonyl compounds.
• 559. The ultra-violet absorption spectra of some pyrroles
  作者：Gerald H. Cookson

  DOI：10.1039/jr9530002789

  日期：——