L-leucine-4-methoxy-2-naphthylamide | 23576-37-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-leucine-4-methoxy-2-naphthylamide
• 英文别名: L-Leucin-(4-methoxy-[2]naphthylamid)；(2S)-2-amino-N-(4-methoxynaphthalen-2-yl)-4-methylpentanamide
• CAS: 23576-37-6
• 化学式: C₁₇H₂₂N₂O₂
• 分子量: 286.374
• InChiKey: MVVPAYGKZXZGRC-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2924299090

反应信息

• 作为产物：
  描述：

  1,3-二硝基萘 在 盐酸 、 甲醇 、 sodium sulfide 、 palladium on activated charcoal 、 二氯甲烷 、 碳酸氢钠 、 potassium carbonate 、 N,N'-二环己基碳二亚胺 、 丙酮 、 硫酸二甲酯 作用下， 生成 L-leucine-4-methoxy-2-naphthylamide
  参考文献：
  名称：

  Synthesis of m-Methoxynaphthylamines as Precursors for Chromogenic Substrates

  摘要：

  DOI：

  10.1021/ja01543a029

文献信息

• Microorganisms detection methods and the separation of agglutinated microorganisms, and a kit for use therein
  申请人：E-Y LABORATORIES, INC.

  公开号：EP0122023A1

  公开（公告）日：1984-10-17

  A test for the differential detection of suspected N. gonorrhoeae (N.g.) and N. meningitidis (N.m.) in provided by contacting a suspected sample with a lectin, preferably wheat germ agglutinin and either soy bean agglutinin or STA potato lectin. An agglutinin reaction is a positive indication of the presence of such microorganisms. Separate portions of the specimen may be contaced with fast substrates specific for (a) N.g., (b) N.m., and (c) B. catarrhalis. Suitable fast substrates are proline naphthylamide, gamma glutamyl naphthylamide, and glycyl prolyl naphthylamide, respectively, each substituted with an electron donating group at the 4-position, 6-position, or both. Another portion of the specimen may be reacted with a substrate for beta-galactosidase enzyme, a positive reaction being an indication that the specimen contains N.lactimica. Autoagglutination, which could otherwise give a false positive in the lectin test, may be prevented by pretreatment of the specimen with DNA'ase and/or an anhydride such as succinic anhydride.

  一种用于鉴别检测疑似淋球菌（N.g.）和脑膜炎双球菌（N.m.）的检测方法是将疑似样本与凝集素（最好是小麦胚芽凝集素和大豆凝集素或 STA 马铃薯凝集素）接触。凝集素反应是此类微生物存在的阳性指标。标本的不同部分可分别与(a) N.g.、(b) N.m.和(c) B. catarrhalis 的特异性快速底物反应。合适的快速底物分别是脯氨酸萘甲酰胺、γ-谷氨酰萘甲酰胺和甘氨酰脯氨酰萘甲酰胺，每种底物都在 4 位、6 位或两者上被电子捐赠基团取代。标本的另一部分可与β-半乳糖苷酶的底物反应，阳性反应表明标本中含有乳酸奈米卡氏菌。用 DNA'ase 和/或酸酐（如琥珀酸酐）对标本进行预处理，可防止自身凝集，否则会在凝集素检测中出现假阳性。
• Recombinant DNA molecules encoding aminopeptidase enzymes and their use in the preparation of vaccines against helminth infections
  申请人：——

  公开号：US20030078398A1

  公开（公告）日：2003-04-24

  The present invention provides nucleic acid molecules containing nucleotide sequences encoding helminth aminopeptidase enzymes, and antigenic fragments and functionally-equivalent variants thereof, their use in the preparation of vaccines, for use against helminth parasites, and synthetic polypetides encoded by them.

  本发明提供了含有编码螺旋体氨肽酶核苷酸序列的核酸分子及其抗原片段和功能等效变体，它们在制备疫苗中的用途，用于防治螺旋体寄生虫，以及由它们编码的合成多肽。
• A process for the identification of bacteria and a kit of reagents for use in this process
  申请人：NATIONAL RESEARCH DEVELOPMENT CORPORATION

  公开号：EP0018825B1

  公开（公告）日：1985-02-13
• RECOMBINANT DNA MOLECULES ENCODING AMINOPEPTIDASE ENZYMES AND THEIR USE IN THE PREPARATION OF VACCINES AGAINST HELMINTH INFECTIONS
  申请人：THE BABRAHAM INSTITUTE

  公开号：EP0640133B1

  公开（公告）日：2000-08-09
• HELMINTH PARASITE ANTIGEN WITH AMINOPEPTIDASE-LIKE ACTIVITY
  申请人：THE BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL

  公开号：EP0726950A1

  公开（公告）日：1996-08-21