4-(perfluorobenzylideneamino)benzyl 4-methylcoumarin-7-ylcarbamate | 1242954-88-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 4-(perfluorobenzylideneamino)benzyl 4-methylcoumarin-7-ylcarbamate
• 英文别名: [4-[(2,3,4,5,6-pentafluorophenyl)methylideneamino]phenyl]methyl N-(4-methyl-2-oxochromen-7-yl)carbamate
• CAS: 1242954-88-6
• 化学式: C₂₅H₁₅F₅N₂O₄
• 分子量: 502.397
• InChiKey: WOQSGOQBFXVYJH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  36
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  77
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  4-(perfluorobenzylideneamino)benzyl 4-methylcoumarin-7-ylcarbamate 生成 7-氨基-4-甲基香豆素
  参考文献：
  名称：

  Schiff bases derived from p-aminobenzyl alcohol as trigger groups for pH-dependent prodrug activation

  摘要：

  A number of novel acid-sensitive Schiff bases derived horn p-aminobenzyl alcohol and various benzaldehyde derivatives were synthesized and were subsequently shown to trigger benzyl elimination reactions The kinetics of acid-catalyzed hydiolysis at pH 50 as well as stability at pH 74 were studied using fluorogenic model compounds Two fluoro-substituted Schiff bases showed efficient hydrolysis at pH 5 0 combined with a long-term stability at pH 74 and are considered suitable candidates for the development of anticancer prodrugs (c) 2010 Elsevier Ltd All lights reserved

  DOI：

  10.1016/j.tetlet.2010.06.055
• 作为产物：
  描述：

  4-(perfluorobenzylideneamino)benzyl alcohol 、 7-isocyanato-4-methylcoumarin 在 二月桂酸二丁基锡 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 0.5h， 以87%的产率得到4-(perfluorobenzylideneamino)benzyl 4-methylcoumarin-7-ylcarbamate
  参考文献：
  名称：

  Schiff bases derived from p-aminobenzyl alcohol as trigger groups for pH-dependent prodrug activation

  摘要：

  A number of novel acid-sensitive Schiff bases derived horn p-aminobenzyl alcohol and various benzaldehyde derivatives were synthesized and were subsequently shown to trigger benzyl elimination reactions The kinetics of acid-catalyzed hydiolysis at pH 50 as well as stability at pH 74 were studied using fluorogenic model compounds Two fluoro-substituted Schiff bases showed efficient hydrolysis at pH 5 0 combined with a long-term stability at pH 74 and are considered suitable candidates for the development of anticancer prodrugs (c) 2010 Elsevier Ltd All lights reserved

  DOI：

  10.1016/j.tetlet.2010.06.055

文献信息

• Schiff bases derived from p-aminobenzyl alcohol as trigger groups for pH-dependent prodrug activation
  作者：Ivonne A. Müller、Felix Kratz、Manfred Jung、André Warnecke

  DOI：10.1016/j.tetlet.2010.06.055

  日期：2010.8

  A number of novel acid-sensitive Schiff bases derived horn p-aminobenzyl alcohol and various benzaldehyde derivatives were synthesized and were subsequently shown to trigger benzyl elimination reactions The kinetics of acid-catalyzed hydiolysis at pH 50 as well as stability at pH 74 were studied using fluorogenic model compounds Two fluoro-substituted Schiff bases showed efficient hydrolysis at pH 5 0 combined with a long-term stability at pH 74 and are considered suitable candidates for the development of anticancer prodrugs (c) 2010 Elsevier Ltd All lights reserved