4-Hydroxy-4-methyl-capronsaeure | 93152-28-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 4-Hydroxy-4-methyl-capronsaeure
• 英文别名: (+/-)-4-hydroxy-4-methyl-hexanoic acid；(+/-)-4-Hydroxy-4-methyl-hexansaeure；4-Hydroxy-4-methylhexanoic acid
• CAS: 93152-28-4
• 化学式: C₇H₁₄O₃
• 分子量: 146.186
• InChiKey: BHWOTLCMMUBASI-UHFFFAOYSA-N

物化性质

• 沸点：
  145-150 °C(Press: 50 Torr)
• 密度：
  1.0036 g/cm3(Temp: 22 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-Hydroxy-4-methyl-capronsaeure 生成 4-甲基-4-己内酯
  参考文献：
  名称：

  719.含叔碳原子的羧酸的氧化。第二部分

  摘要：

  DOI：

  10.1039/jr9530003580
• 作为产物：
  描述：

  (4S)-4-甲基-己酸 在 potassium permanganate 、 alkaline solution 作用下， 生成 4-Hydroxy-4-methyl-capronsaeure
  参考文献：
  名称：

  436.含有叔碳原子的羧酸的氧化

  摘要：

  DOI：

  10.1039/jr9530002129

文献信息

• POLYURETHANES
  申请人：Ercole Francesca

  公开号：US20120252967A1

  公开（公告）日：2012-10-04

  The present invention relates to a polyurethane polymer comprising as part of its polymer backbone an α-oxy carbonyl moiety of general formula (I), where A and B represent the remainder of the polymer backbone and are the same or different, and R is an optionally substituted aliphatic hydrocarbon having three or more carbon atoms.

  本发明涉及一种聚氨酯聚合物，其聚合物主链中包含通式(I)的α-氧基羰基基团，其中A和B代表聚合物主链的其余部分，可以相同也可以不同，R是具有三个或三个以上碳原子的可选择取代的脂肪族碳氢化合物。
• Process for the preparation of lactic acid polyesters
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0603889A2

  公开（公告）日：1994-06-29

  [Construction] In a preparation process of a polyhydroxycarboxylic acid comprising carrying out dehydration polycondensation of hydroxycarboxylic acids which contain at least lactic acid in an organic solvent in the presence or in the absence of a catalyst a preparation process of the polyhydroxycarboxylic acid comprising use of a raw material containing ethyllactate of which amount is 0.3 mole % or less to a reduced mole number of the raw material monomer. [Effect] A high molecular weight of polyhydroxycarboxylic acid is obtained with ease and with inexpensive industrially by a direct polycondensation of a hydroxycarboxylic acid which contains at least lactic acid.

  施工 在聚羟基羧酸的制备工艺中，包括在有机溶剂中，在有催化剂存在或无催化剂存在的情况下，对至少含有乳酸的羟基羧酸进行脱水缩聚，聚羟基羧酸的制备工艺包括使用含有乙内酯的原料，乙内酯的量占原料单体减少摩尔数的 0.3 摩尔%或更少。 效果 通过直接缩聚至少含有乳酸的羟基羧酸，可以方便地获得高分子量的聚羟基羧酸，而且工业成本低廉。
• Polyhydroxycarboxylic acid and purification process thereof
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0591978A2

  公开（公告）日：1994-04-13

  A purification process of a polyhydroxycarboxylic acid for efficiently removing a catalyst with a simple method from solid polyhydroxycarboxylic acid by bringing the solid polyhydroxycarboxylic acid which is obtained by a catalytic reaction and has an inherent viscosity of 0. 1 to 5. 0 dl/g into contact with an acid substance in the presence of a hydrophilic organic solvent and a polyhydroxycarboxylic acid prepared by direct dehydration polymerization having extremely reduced content of the residual catalyst.

  一种聚羟基羧酸的纯化工艺，它能以简单的方法从固体聚羟基羧酸中有效地去除催化剂，其方法是将通过催化反应得到的固有粘度为0.1至5.0分升/克的固体聚羟基羧酸在亲水性有机溶剂存在下与酸性物质接触，并将通过直接脱水聚合制备的聚羟基羧酸与残留催化剂含量极低的聚羟基羧酸接触。
• Purification process of polyhydroxycarboxylic acids
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0707024A2

  公开（公告）日：1996-04-17

  The invention relates to a purification process for polyhydroxycarboxylic acids which comprises dissolving a polyhydroxycarboxylic acid in an water-immiscible phenol or an organic solvent containing said water-immiscible phenol, successively bringing the resulting solution into contact with water which contains an acidic material, separating the organic layer from an aqueous layer, and isolating polyhydroxycarboxylic acid from the organic layer; and the process of the invention can efficiently remove a catalyst contained in polyhydroxycarbo xylic acid prepared in the presence of the catalyst, not always requires to take out polyhydroxycarboxylic acid in the form of a solid, and can treat polyhydroxycarboxylic acid in a higher concentration as compared with the case using chlorinated hydrocarbon as a solvent. Polyhydroxycarboxylic acid obtained by the purification process of the invention can be used for slow release drugs with safety. Polyhydroxycarboxylic acid of the invention has also excellent mechanical properties, heat resistance and weatherability, and thus is stable in a thermoforming stage, can be molded or processed with ease, and can be used for the material of various kinds of films and workpieces.

  本发明涉及一种多羟基羧酸的纯化工艺，该工艺包括将多羟基羧酸溶解在水不混溶苯酚或含有上述水不混溶苯酚的有机溶剂中，先后将所得溶液与含有酸性物质的水接触，从水层中分离出有机层，并从有机层中分离出多羟基羧酸；本发明的工艺可以有效地除去在催化剂存在下制备的聚羟基羧酸中所含的催化剂，不一定需要以固体形式取出聚羟基羧酸，而且与使用氯化烃作为溶剂的情况相比，可以处理更高浓度的聚羟基羧酸。 通过本发明的纯化工艺获得的聚羟基羧酸可安全地用于缓释药物。本发明的聚羟基羧酸还具有优异的机械性能、耐热性和耐候性，因此在热成型阶段稳定，可轻松成型或加工，并可用于各种薄膜和工件的材料。
• Preparation process of aliphatic polyester
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0826711A2

  公开（公告）日：1998-03-04

  The invention relates to a preparation process of aliphatic polyester, comprising using an ion exchange resin as a drying agent and after the dehydration polycondensation reaction, regenerating and drying the used ion exchange resin and repeatedly using said ion exchange resin in the next dehydration polycondensation reaction, in a process for preparing aliphatic polyester from one or more aliphatic compound (A) by heating in an organic solvent in the presence of a catalyst, distilling a generated water containing organic solvent out of the reaction system, treating the distilled organic solvent with a drying agent, and returning the treated solvent to the reaction system to progress a dehydration polycondensation reaction. The process of the invention enables to steadily and efficiently prepare in industry an aliphatic polyester having an excellent color tone, high molecular weight and high quality.

  本发明涉及一种脂肪族聚酯的制备工艺，包括使用离子交换树脂作为干燥剂，并在脱水缩聚反应后，对使用过的离子交换树脂进行再生和干燥，并在下一次脱水缩聚反应中重复使用所述离子交换树脂、在由一种或多种脂肪族化合物（A）制备脂肪族聚酯的工艺中，在催化剂存在下，在有机溶剂中加热，将生成的含水有机溶剂从反应体系中蒸馏出来，用干燥剂处理蒸馏后的有机溶剂，并将处理后的溶剂返回反应体系以进行脱水缩聚反应。 通过本发明的工艺，可以在工业上稳定、高效地制备出色调优异、分子量高、质量好的脂肪族聚酯。