meso-β,β'-disulfanediyl-di-valine | 687973-24-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: meso-β,β'-disulfanediyl-di-valine
• 英文别名: meso-β,β'-Disulfandiyl-di-valin；(2R)-2-azaniumyl-3-[[(1S)-1-azaniumyl-1-carboxylato-2-methylpropan-2-yl]disulfanyl]-3-methylbutanoate
• CAS: 687973-24-6
• 化学式: C₁₀H₂₀N₂O₄S₂
• 分子量: 296.412
• InChiKey: POYPKGFSZHXASD-OLQVQODUSA-N

物化性质

• 沸点：
  467.0±45.0 °C(Predicted)
• 密度：
  1.353±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于甲醇；水

计算性质

• 辛醇/水分配系数(LogP)：
  -5
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  177
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  meso-β,β'-disulfanediyl-di-valine 、 苯甲酰氯 在 sodium hydroxide 作用下， 生成 N,N'-dibenzoyl-β,β'-disulfanediyl-di-valine
  参考文献：
  名称：

  Butenandt et al., Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1950, vol. 285, p. 238,243

  摘要：

  DOI：
• 作为产物：
  描述：

  DL-青霉胺 在 air 、 三氯化铁 作用下， 生成 meso-β,β'-disulfanediyl-di-valine
  参考文献：
  名称：

  Coesite inclusions in zircon from gneisses identified by laser Raman microspectrometer in ultrahigh pressure zone of Dabie Mountains, China

  摘要：

  The mineral inclusions in zircon from gneisses in ultra-high pressure (UHP) zone of the Dable Mountains were identified by using a laser Raman microspectrometer. Coesite occurs as inclusions in zircons from all types of gneiss. Other important minerals, such as jadeite, omphacite, aragonite, barite, and anhydrite were also found as inclusion minerals. These discoveries indicate that (i) gneissic country rocks had metamorphosed at the same time as the enclosed eclogites; and (ii) SO4-2-bearing fluids were present in the UHP metamorphic process, which is manifested by occurrence of barite and anhydrite coexisting with coesite.

  DOI：

  10.1007/bf02901171

文献信息

• [EN] COMPOUNDS AS L-CYSTINE CRYSTALLIZATION INHIBITORS AND USES THEREOF<br/>[FR] COMPOSÉS COMME INHIBITEURS DE LA CRISTALLISATION DE LA L-CYSTINE ET UTILISATIONS ASSOCIÉES
  申请人：UNIV NEW YORK

  公开号：WO2011062640A1

  公开（公告）日：2011-05-26

  A method of preventing or inhibiting L-cystine crystallization using the compounds of formula (I) is disclosed, wherein A, L, R1a, R1b, and m are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of conditions that are causally related to L-cystine crystallization, such as comprising (but not limited to) kidney stones.

  揭示了一种使用式(I)化合物预防或抑制L-半胱氨酸结晶的方法，其中A、L、R1a、R1b和m如本文所述。这些化合物可以制备为药物组合物，并可用于预防和治疗与L-半胱氨酸结晶有因果关系的病症，例如包括（但不限于）肾结石。
• Crooks, Chemistry of Penicillin
  作者：Crooks

  DOI：——

  日期：——
• COMPOUNDS AS L-CYSTINE CRYSTALLIZATION INHIBITORS AND USES THEREOF
  申请人：Ward Michael D.

  公开号：US20110177173A1

  公开（公告）日：2011-07-21

  A method of preventing or inhibiting L-cystine crystallization using the compounds of formula I is disclosed. R 1a —O-(-A-L-) m -A-O—R 1b I, wherein A, L, R 1a , R 1b , and m are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of conditions that are causally related to L-cystine crystallization, such as comprising (but not limited to) kidney stones.
• US8450089B2
  申请人：——

  公开号：US8450089B2

  公开（公告）日：2013-05-28
• US9040261B2
  申请人：——

  公开号：US9040261B2

  公开（公告）日：2015-05-26