7-(hydroxypropoxy)-4-(hydroxymethyl)coumarin | 1441758-07-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-(hydroxypropoxy)-4-(hydroxymethyl)coumarin
• 英文别名: 7-(Hydroxypropoxy)-4-(hydroxymethyl)coumarin；4-(hydroxymethyl)-7-(3-hydroxypropoxy)chromen-2-one
• CAS: 1441758-07-1
• 化学式: C₁₃H₁₄O₅
• 分子量: 250.251
• InChiKey: KZNDSELPNZOBCU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  间苯二酚 在 18-冠醚-6 、 水 、 potassium carbonate 、 对甲苯磺酸 作用下， 以 丙酮 、 甲苯 为溶剂， 反应 75.2h， 生成 7-(hydroxypropoxy)-4-(hydroxymethyl)coumarin
  参考文献：
  名称：

  BIO-INSPIRED AND ANTIMICROBIAL POLYMERS CONTAINING AMINO ACID-LIKE MONOMER BUILDING BLOCKS

  摘要：

  提供了一种杀灭微生物的方法，包括向微生物引入一个功能化酰胺聚合物，其中该功能化酰胺聚合物包括从聚酯和聚氨酯中选择的聚合物骨架；一个带有挂链功能基团的酰胺基团，其中酰胺基团的氮原子是聚合物骨架的一部分；以及净正电荷。

  公开号：

  US20170172147A1

文献信息

• [EN] PHOTORESPONSIVE COUMARIN BASED POLYMERS: SYNTHESIS AND APPLICATIONS<br/>[FR] POLYMÈRES PHOTOSENSIBLES À BASE DE COUMARINE : SYNTHÈSE ET APPLICATIONS
  申请人：UNIV AKRON

  公开号：WO2014074845A1

  公开（公告）日：2014-05-15

  A photoactive coumarin monomer includes a substituted coumarin molecule that has at least two functional groups may be used to produce a polymer with a coumarin unit or a coumarin derivative unit as part of the polymer backbone. The polymer with a coumarin unit or a coumarin derivative unit as part of the polymer backbone may be photoresponsive and/or bioabsorbable. Photoresponsive polymers with a coumarin unit or a coumarin derivative unit as part of the polymer backbone may crosslink when irradiated at a wavelength of about 320 nm to about 420 nm. The crosslink may be separated when the polymers are irradiated at a wavelength of about 230 nm to about 300. The polymers may also photocleave when irradiated with light at a wavelength of about 230 nm to about 300.

  一种光敏香豆素单体包括一个取代的香豆素分子，该分子具有至少两个功能基团，可用于制备具有香豆素单元或香豆素衍生单元作为聚合物骨架的聚合物。具有香豆素单元或香豆素衍生单元作为聚合物骨架的聚合物可能具有光响应性和/或生物可吸收性。具有香豆素单元或香豆素衍生单元作为聚合物骨架的光响应性聚合物可能在波长为约320 nm至约420 nm的辐射下交联。当聚合物在波长为约230 nm至约300 nm的辐射下时，交联可以分离。聚合物也可以在波长为约230 nm至约300 nm的光照下光解。
• Photoresponsive polymers for adhesive applications
  申请人：Joy Abraham

  公开号：US10336923B2

  公开（公告）日：2019-07-02

  Provided is a pressure sensitive adhesive polymer comprising adhesive polymerscrosslinked with a crosslinker that includes a photoresponsive group. Also provided is a method for preparing a pressure sensitive adhesive polymer comprising: polymerizing an vinyl monomer and photoresponsive crosslinker with two acryl end groups.

  本发明提供了一种压敏型粘合剂聚合物，它由粘合剂聚合物与交联剂交联而成，交联剂包括一个光致抗蚀剂基团。还提供了一种制备压敏型粘合剂聚合物的方法，包括：聚合乙烯基单体和具有两个丙烯酸末端基团的光致抗蚀性交联剂。
• Photoresponsive Coumarin Polyesters That Exhibit Cross-Linking and Chain Scission Properties
  作者：Murthy V. S. N. Maddipatla、Daniel Wehrung、Chuan Tang、Weizheng Fan、Moses O. Oyewumi、Toshikazu Miyoshi、Abraham Joy

  DOI：10.1021/ma400584y

  日期：2013.7.9

  The synthesis and properties of a new class of photoresponsive coumarin polyesters are described Incorporation of the coumarin chromophore in the polymer. chain provides interesting properties such as polymer chain crosslinking upon irradiation at 350 nm and chain un-cross-linking When irradiated at 254 nm. In addition, irradiation at 254 nm also results in polymer chain scission. The cross linking, un-cross-linking, and chain scission properties were studied by ssNMR, ATR-IR, and GPC measurements These properties enable the fabrication of 2D surfaces having complementary micropatterned features. Also, initial biocompatibility profiles of the polymers and their irradiation products were demonstrated using MTT assays.
• PHOTORESPONSIVE COUMARIN BASED POLYMERS: SYNTHESIS AND APPLICATIONS
  申请人：The University of Akron

  公开号：EP2917196A1

  公开（公告）日：2015-09-16
• PHOTORESPONSIVE POLYMERS FOR ADHESIVE APPLICATIONS
  申请人：The University of Akron

  公开号：EP3142617A1

  公开（公告）日：2017-03-22