p-(4-{[2',3',4',6'-tetra-O-acetyl-β-D-glucopyranosyl]sulfonylmethyl}-5-iodo-1H-1,2,3-triazol-1-yl)benzenesulfonamide | 1333497-89-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: p-(4-{[2',3',4',6'-tetra-O-acetyl-β-D-glucopyranosyl]sulfonylmethyl}-5-iodo-1H-1,2,3-triazol-1-yl)benzenesulfonamide
• 英文别名: [(2R,3R,4S,5R,6S)-3,4,5-triacetyloxy-6-[[5-iodo-1-(4-sulfamoylphenyl)triazol-4-yl]methylsulfonyl]oxan-2-yl]methyl acetate
• CAS: 1333497-89-4
• 化学式: C₂₃H₂₇IN₄O₁₃S₂
• 分子量: 758.523
• InChiKey: HUUOHQDOELKFLT-VZWAGXQNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  43
• 可旋转键数：
  14
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  256
• 氢给体数：
  1
• 氢受体数：
  16

反应信息

• 作为反应物：
  描述：

  p-(4-{[2',3',4',6'-tetra-O-acetyl-β-D-glucopyranosyl]sulfonylmethyl}-5-iodo-1H-1,2,3-triazol-1-yl)benzenesulfonamide 在 甲醇 、 sodium methylate 作用下， 以93%的产率得到p-(4-{[β-D-glucopyranosyl]sulfonylmethyl}-5-iodo-1H-1,2,3-triazol-1-yl)benzenesulfonamide
  参考文献：
  名称：

  Targeting Hypoxic Tumor Cell Viability with Carbohydrate-Based Carbonic Anhydrase IX and XII Inhibitors

  摘要：

  Carbonic anhydrase (CA) enzymes, specifically membrane-bound isozymes CA IX and CA XII, underpin a pH-regulating system that enables hypoxic tumor cell survival and proliferation. CA IX and XII are implicated as potential targets for the development of new hypoxic cancer therapies. To date, only a few small molecules have been characterized in CA-relevant cell and animal model systems. In this paper, we describe the development of a new class of carbohydrate-based small molecule CA inhibitors, many of which inhibit CA IX and XII within a narrow range of low nanomolar K-i values (5.3-11.2 nM). We evaluate for the first time carbohydrate-based CA inhibitors in cell-based models that emulate the protective role of CA IX in an acidic tumor microenvironment. Our findings identified two inhibitors (compounds 5 and 17) that block CA IX-induced survival and have potential for development as in vivo cancer cell selective inhibitors.

  DOI：

  10.1021/jm200892s
• 作为产物：
  描述：

  p-(4-{[2',3',4',6'-tetra-O-acetyl-β-D-glucopyranosyl]thiomethyl}-5-iodo-1H-1,2,3-triazol-1-yl)benzenesulfonamide 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以78%的产率得到p-(4-{[2',3',4',6'-tetra-O-acetyl-β-D-glucopyranosyl]sulfonylmethyl}-5-iodo-1H-1,2,3-triazol-1-yl)benzenesulfonamide
  参考文献：
  名称：

  Targeting Hypoxic Tumor Cell Viability with Carbohydrate-Based Carbonic Anhydrase IX and XII Inhibitors

  摘要：

  Carbonic anhydrase (CA) enzymes, specifically membrane-bound isozymes CA IX and CA XII, underpin a pH-regulating system that enables hypoxic tumor cell survival and proliferation. CA IX and XII are implicated as potential targets for the development of new hypoxic cancer therapies. To date, only a few small molecules have been characterized in CA-relevant cell and animal model systems. In this paper, we describe the development of a new class of carbohydrate-based small molecule CA inhibitors, many of which inhibit CA IX and XII within a narrow range of low nanomolar K-i values (5.3-11.2 nM). We evaluate for the first time carbohydrate-based CA inhibitors in cell-based models that emulate the protective role of CA IX in an acidic tumor microenvironment. Our findings identified two inhibitors (compounds 5 and 17) that block CA IX-induced survival and have potential for development as in vivo cancer cell selective inhibitors.

  DOI：

  10.1021/jm200892s

文献信息

• Targeting Hypoxic Tumor Cell Viability with Carbohydrate-Based Carbonic Anhydrase IX and XII Inhibitors
  作者：Jason C. Morris、Johanna Chiche、Caroline Grellier、Marie Lopez、Laurent F. Bornaghi、Alfonso Maresca、Claudiu T. Supuran、Jacques Pouysségur、Sally-Ann Poulsen

  DOI：10.1021/jm200892s

  日期：2011.10.13

  Carbonic anhydrase (CA) enzymes, specifically membrane-bound isozymes CA IX and CA XII, underpin a pH-regulating system that enables hypoxic tumor cell survival and proliferation. CA IX and XII are implicated as potential targets for the development of new hypoxic cancer therapies. To date, only a few small molecules have been characterized in CA-relevant cell and animal model systems. In this paper, we describe the development of a new class of carbohydrate-based small molecule CA inhibitors, many of which inhibit CA IX and XII within a narrow range of low nanomolar K-i values (5.3-11.2 nM). We evaluate for the first time carbohydrate-based CA inhibitors in cell-based models that emulate the protective role of CA IX in an acidic tumor microenvironment. Our findings identified two inhibitors (compounds 5 and 17) that block CA IX-induced survival and have potential for development as in vivo cancer cell selective inhibitors.