1,3,4-三甲基-2,5-哌嗪二酮 | 182067-63-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 1,3,4-三甲基-2,5-哌嗪二酮
• 中文别名: L-丙氨酸,3,3-二氟-2-甲基-(9CI)
• 英文名称: 1,3,4-trimethylpiperazine-2,5-dione
• CAS: 182067-63-6
• 化学式: C₇H₁₂N₂O₂
• 分子量: 156.184
• InChiKey: AMADWOODIDMYTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,3,4-三甲基-2,5-哌嗪二酮 在 N-溴代丁二酰亚胺(NBS) 、 偶氮二异丁腈 、 氘代三正丁基锡 作用下， 以 四氯化碳 、 苯 为溶剂， 生成
  参考文献：
  名称：

  Selectivity in Radical Reactions of Alanylglycine Anhydride Derivatives

  摘要：

  描述了在自由基条件下对N,N′-二取代丙氨酰甘氨酸酐进行官能化的过程。自由基（7）是通过N,N'-二取代丙氨酰甘氨酸酐与N-溴代琥珀酰亚胺反应生成，以及通过与三丁基锡氘反应而产生的，根据N-取代基的不同，会以中等到高的对映选择性进行碳-溴和碳-氘键的形成。

  DOI：

  10.1071/ch9960605
• 作为产物：
  描述：

  3-benzyloxycarbonyl-1,3,4-trimethylpiperazine-2,5-dione 在 palladium on activated charcoal 氢气 作用下， 生成 1,3,4-三甲基-2,5-哌嗪二酮
  参考文献：
  名称：

  Multi-purpose functionality for the structural elaboration of the piperazine-2,5-dione motif

  摘要：

  Mild methods for controlled C- and N-alkylation of 3-benzyloxycarbonylpiperazine-2,5-diones are reported. The benzyloxylcarbonyl substituent can also serve as latent functionality for N-acyliminium ion formation and subsequent trapping enables installation of new carbon and/or heteroatom substituents. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)02571-6

文献信息

• [EN] EPIDITHIODIOXOPIPERAZINE COMPOUND OR ITS DERIVATIVES, AND THE USE THEREOF<br/>[FR] COMPOSÉ ÉPIDITHIODIOXOPIPÉRAZINE OU SES DÉRIVÉS, ET LEUR UTILISATION
  申请人：UNIV EWHA IND COLLABORATION

  公开号：WO2014189343A1

  公开（公告）日：2014-11-27

  The present invention relates to an epidithiodioxopiperazine derivative represented by the Chemical Formula 1 or its reduced derivative; a method for preparing a compound represented by Chemical Formula 1 having improved intracellular permeability and mimicking the activity of 2-Cys-Prx in its reduced form in the cells; a pharmaceutical composition for preventing or treating vascular diseases comprising an epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient; a drug delivery device for local administration including the pharmaceutical composition; and a pharmaceutical composition for inhibiting melanoma metastasis comprising the epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient.

  本发明涉及一种由化学式1表示的二硫代二氧哌嗪衍生物或其还原衍生物；一种制备化学式1所代表的化合物的方法，该化合物具有改善细胞内渗透性并在细胞中模拟其还原形式中2-Cys-Prx的活性；一种用作预防或治疗血管疾病的药物组合物，其包括二硫代二氧哌嗪化合物或其衍生物或其药用盐作为活性成分；一种用于局部给药的药物递送装置，包括该药物组合物；以及一种用作抑制黑色素瘤转移的药物组合物，其包括二硫代二氧哌嗪化合物或其衍生物或其药用盐作为活性成分。
• EPIDITHIODIOXOPIPERAZINE COMPOUND OR ITS DERIVATIVES, AND THE USE THEREOF
  申请人：EWHA University-Industry Collaboration Foundation

  公开号：US20160222031A1

  公开（公告）日：2016-08-04

  The present invention relates to an epidithiodioxopiperazine derivative represented by the following Chemical Formula 1 or its reduced derivative; a method for preparing a compound represented by Chemical Formula 1 having improved intracellular permeability and mimicking the activity of 2-Cys-Prx in its reduced form in the cells; a pharmaceutical composition for preventing or treating vascular diseases comprising an epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient; a drug delivery device for local administration including the pharmaceutical composition; and a pharmaceutical composition for inhibiting melanoma metastasis comprising the epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient.

  本发明涉及以下化学式1所表示的表皮二硫二氧哌嗪衍生物或其还原衍生物；一种制备化学式1所表示的化合物的方法，该方法具有改善细胞内渗透性并在其还原形式下模拟2-Cys-Prx在细胞中的活性；一种预防或治疗血管疾病的制药组合物，包括表皮二硫二氧哌嗪化合物或其衍生物或其药学上可接受的盐作为活性成分；一种用于局部给药的药物递送装置，包括该制药组合物；以及一种抑制黑色素瘤转移的制药组合物，包括表皮二硫二氧哌嗪化合物或其衍生物或其药学上可接受的盐作为活性成分。
• Epidithiodioxopiperazine compound or its derivatives, and the use thereof
  申请人：VASTHERA Co. Ltd.

  公开号：US10450327B2

  公开（公告）日：2019-10-22

  The present invention relates to an epidithiodioxopiperazine derivative represented by the following Chemical Formula 1 or its reduced derivative; a method for preparing a compound represented by Chemical Formula 1 having improved intracellular permeability and mimicking the activity of 2-Cys-Prx in its reduced form in the cells; a pharmaceutical composition for preventing or treating vascular diseases comprising an epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient; a drug delivery device for local administration including the pharmaceutical composition; and a pharmaceutical composition for inhibiting melanoma metastasis comprising the epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient.

  本发明涉及一种由以下化学式1代表的表二硫代二酮哌嗪衍生物或其还原衍生物；一种制备由化学式1代表的化合物的方法，该化合物具有更好的细胞内渗透性，并能模拟细胞内还原形式的2-Cys-Prx的活性；一种用于预防或治疗血管疾病的药物组合物，其活性成分包括表二硫基二氧代哌嗪化合物或其衍生物或其药学上可接受的盐类；一种用于局部给药的给药装置，其活性成分包括该药物组合物；以及一种用于抑制黑色素瘤转移的药物组合物，其活性成分包括表二硫基二氧代哌嗪化合物或其衍生物或其药学上可接受的盐类。
• Age-Related Differences in Supervisory Attentional System Functions
  作者：P. Andres、M. Van der Linden

  DOI：10.1093/geronb/55.6.p373

  日期：2000.11.1

  The authors explored the effect of age on executive functions by using 3 tasks (Tower of London, Hayling, and Brixton tests) designed to assess specific executive processes (planning, inhibition, and abstraction of logical rules) that were also sensitive to frontal dysfunction. The performance of elderly participants (n = 48) was significantly poorer than that of young participants (n = 47) in all 3 tasks. Processing speed, measured by means of a color-naming task, explained some but not all of the age-related differences. These results are discussed in terms of general and specific factors in cognitive aging.
• US7772190B2
  申请人：——

  公开号：US7772190B2

  公开（公告）日：2010-08-10