(R)-4-Amino-5-phenyl-pentanoic acid methyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R)-4-Amino-5-phenyl-pentanoic acid methyl ester
• 英文别名: Methyl (4r)-4-amino-5-phenylpentanoate；methyl (4R)-4-amino-5-phenylpentanoate
• 化学式: C₁₂H₁₇NO₂
• 分子量: 207.272
• InChiKey: GNTXIYNIBVBPJG-LLVKDONJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  二碳酸二叔丁酯 、 (R)-4-Amino-5-phenyl-pentanoic acid methyl ester 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以70 mg的产率得到(R)-4-(tert-butoxycarbonylamino)-5-phenylpentanoic acid methyl ester
  参考文献：
  名称：

  Co-Catalyzed Direct Regio- and Enantioselective Intermolecular γ-Amination of N-Acylpyrazoles

  摘要：

  DOI：

  10.1021/acs.orglett.0c03522
• 作为产物：
  描述：

  N-Boc-L-苯丙氨醛 在 palladium on activated charcoal 氢气 、 三氟乙酸 作用下， 以 甲醇 为溶剂， 生成 (R)-4-Amino-5-phenyl-pentanoic acid methyl ester
  参考文献：
  名称：

  1,3-Asymmetric induction in enolate alkylation reactions of N-protected γ-amino acid derivatives

  摘要：

  Dianions derived from N-TFA and N-Boc gamma-amino acid esters and amides undergo highly stereoselective alpha-alkylation reactions The roles of HMPA, of the cation, the electrophile, and of steric factors were studied. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0040-4039(96)02263-0

文献信息

• TUBULYSIN ANALOGUES AS ANTICANCER AGENTS AND PAYLOADS FOR ANTIBODY-DRUG CONJUGATES AND METHODS OF TREATMENT THEREWITH
  申请人：William Marsh Rice University

  公开号：US20210188906A1

  公开（公告）日：2021-06-24

  In one aspect, the present disclosure provides tubulysin analogs of the formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.
• 1,3-Asymmetric induction in enolate alkylation reactions of N-protected γ-amino acid derivatives
  作者：Stephen Hanessian、Robert Schaum

  DOI：10.1016/s0040-4039(96)02263-0

  日期：1997.1

  Dianions derived from N-TFA and N-Boc gamma-amino acid esters and amides undergo highly stereoselective alpha-alkylation reactions The roles of HMPA, of the cation, the electrophile, and of steric factors were studied. Copyright (C) 1996 Elsevier Science Ltd
• Co-Catalyzed Direct Regio- and Enantioselective Intermolecular γ-Amination of <i>N</i>-Acylpyrazoles
  作者：Xin Fu、Yu Hao、He-Yuan Bai、Abing Duan、Shu-Yu Zhang

  DOI：10.1021/acs.orglett.0c03522

  日期：2021.1.1