2,2'-Dithiobis- | 82993-28-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2,2'-Dithiobis-
• 英文别名: 2,2'-disulfanediyl-bis-thiazole-4-carboxylic acid diethyl ester；Ethyl 2-[(4-ethoxycarbonyl-1,3-thiazol-2-yl)disulfanyl]-1,3-thiazole-4-carboxylate
• CAS: 82993-28-0
• 化学式: C₁₂H₁₂N₂O₄S₄
• 分子量: 376.502
• InChiKey: SETPNXUFTMNOCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  186
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  2-巯基噻唑-4-羧酸乙酯 在 ammonium peroxydisulfate 作用下， 生成 2,2'-Dithiobis-
  参考文献：
  名称：

  Thiazolethiols and Their Derivatives

  摘要：

  DOI：

  10.1021/jo01078a014

文献信息

• METHOD OF IMMUNOMODULATION USING THIONE-FORMING DISULFIDES
  申请人：The GRASSETTI Family Trust

  公开号：EP1383499B1

  公开（公告）日：2013-03-06
• COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY
  申请人：Novartis AG

  公开号：EP3880673A1

  公开（公告）日：2021-09-22
• Method of immunomodulation using thione-forming disulfides
  申请人：——

  公开号：US20040265327A1

  公开（公告）日：2004-12-30

  The invention provides for the methods of modulating an immune response in an individual by administration of a thione-forming disulfide (TFD). Immunomodulatory responses include, but are not limited to, increased natural killer cell activity, expansion of NK cell population, decreased B cell population, decreased antibody production, and increased mitogenic potential. Methods of modulating such immune responses and the uses of immunomodulation are provided herein.
• Inhibition of IL-1 Induced Inflammation
  申请人：THIOLAB, LLC.

  公开号：US20220193060A1

  公开（公告）日：2022-06-23

  This invention provides methods of treatment for a variety of inflammation pathologies using thione-forming disulfides (TFDs). The treatments are particularly effective in the context of inflammations primarily due to excessive activity of innate immune system components, macrophage activity and inflammation arising from excessive production of IL-1. TFD inhibition of both IL-1 and IL-6 can reduce the detrimental effects of the cytokine storms known to increase morbidity and mortality caused by certain infections, such as COVID-19 viral pneumonia.
• US4378364A
  申请人：——

  公开号：US4378364A

  公开（公告）日：1983-03-29