Ac-Sar-OMe | 19149-94-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Ac-Sar-OMe
• 英文别名: N-acetyl sarcosine O-methyl ester；methyl 2-[acetyl(methyl)amino]acetate
• CAS: 19149-94-1
• 化学式: C₆H₁₁NO₃
• mdl: MFCD12144401
• 分子量: 145.158
• InChiKey: OERLSHUHJSEQCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Ac-Sar-OMe 在 lithium hydroxide monohydrate 、 水 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 以31%的产率得到2-[乙酰基(甲基)氨基]乙酸
  参考文献：
  名称：

  Enhancing Mechanical Performance of a Covalent Self-Healing Material by Sacrificial Noncovalent Bonds

  摘要：

  Polymers that repair themselves after mechanical damage can significantly improve their durability and safety. A major goal in the field of self-healing materials is to combine robust mechanical and efficient healing properties. Here, we show that incorporation of sacrificial bonds into a self-repairable network dramatically improves the overall mechanical properties. Specifically, we use simple secondary amide side chains to create dynamic energy dissipative hydrogen bonds in a covalently cross-linked polymer network, which can self-heal via olefin cross-metathesis. We envision that this straightforward sacrificial bonding strategy can be employed to improve mechanical properties in a variety of self-healing systems.

  DOI：

  10.1021/jacs.5b01601
• 作为产物：
  描述：

  肌氨酸甲酯盐酸盐 、 乙酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以45%的产率得到Ac-Sar-OMe
  参考文献：
  名称：

  Proline-rich proteins—deriving a basis for residue-based selectivity in polyphenolic binding

  摘要：

  1H NMR 滴定实验证明，相对于其他类似的受保护氨基酸残基，基于脯氨酸的最小模型在 CDCl3 中对苯酚的结合选择性更强。协同结合效应似乎在其中发挥了作用，肌氨酸模型与苯酚的结合常数介于脯氨酸模型和其他氨基酸模型得到的结合常数之间。根据 DFT 计算和亨特分子识别工具箱模型的应用，结合机制不能完全归因于氢键强度，而似乎是通过 CâH-Ï 键和酰胺底物的旋转自由度介导的。

  DOI：

  10.1039/b800365c

文献信息

• [EN] 2-AMINOCARBONYL-QUINOLINE COMPOUNDS AS PLATELET ADENOSINE DIPHOSPHATE RECEPTOR ANTAGONISTS<br/>[FR] COMPOSES DE 2-AMINOCARBONYL-QUINOLINE UTILISES EN TANT QU'ANTAGONISTES DU RECEPTEUR DE L'ADENOSINE DIPHOSPHATE DES PLAQUETTES
  申请人：SCHERING AG

  公开号：WO2004052366A1

  公开（公告）日：2004-06-24

  Compounds of formula (I), where m, n, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.

  式（I）中的化合物，其中m、n、R1、R2、R3、R4和R6如本文所述，可用作血小板腺苷二磷酸酶抑制剂。本文还描述了含有这些化合物的药物组合物、使用这些化合物作为抗血栓剂的方法以及合成这些化合物的方法。
• Platelet adenosine diphosphate receptor antagonists
  申请人：Schering Aktiengesellschaft

  公开号：US20030060474A1

  公开（公告）日：2003-03-27

  Compounds of the following formula (I): 1 where a, b, R 1 , R 2 , R 4 and R 6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.

  以下公式（I）的化合物：其中a、b、R1、R2、R4和R6如下所述，可用作抑制血小板腺苷二磷酸的药物。本文还描述了含有这些化合物的药物组合物，使用这些化合物作为抗血栓药物的方法以及合成这些化合物的过程。
• COMPOSITION, ARTIFICIAL NAIL COMPOSITION, NAIL DECORATION MATERIAL, ARTIFICIAL NAIL, STORED CONTAINER, IMAGE FORMING APPARATUS, AND IMAGE FORMING METHOD
  申请人：Suenaga Takenori

  公开号：US20200038309A1

  公开（公告）日：2020-02-06

  Provided is a composition including: an acrylamide compound represented by general formula (1) in 20% by mass or greater but 50% by mass or less; a multifunctional monomer in 40% by mass or greater but 70% by mass or less; and a polymerization initiator, where in general formula (1), R 1 represents alkyl group containing 1 through 6 carbon atoms, X represents alkylene group containing 1 through 6 carbon atoms, and Y represents any one selected from the group consisting of general formula (2) below and general formula (3) below, where in general formula (2), R 2 represents alkyl group containing 1 through 10 carbon atoms, and * represents binding site with X above, where in general formula (3), R 2 represents alkyl group containing 1 through 10 carbon atoms, and * represents binding site with X above.

  提供的是一种组合物，包括：质量分数为20%或更高但不超过50%的一种由一般式（1）表示的丙烯酰胺化合物；质量分数为40%或更高但不超过70%的多功能单体；以及聚合引发剂。其中，在一般式（1）中，R1表示含有1至6个碳原子的烷基基团，X表示含有1至6个碳原子的亚烷基基团，Y表示从以下公式（2）和以下公式（3）组成的群中任选一种。在一般式（2）中，R2表示含有1至10个碳原子的烷基基团，“*”表示与上述X结合的结合位点。在一般式（3）中，R2表示含有1至10个碳原子的烷基基团，“*”表示与上述X结合的结合位点。
• Amidine compounds and herbicides
  申请人：Miyashita Yasuhiro

  公开号：US20110301355A1

  公开（公告）日：2011-12-08

  Novel amidine compounds which may be active ingredients in herbicides that are reliably effective at a lesser dose and highly safe, and herbicides containing these compounds as active ingredients are provided. Amidine compounds represented by a formula (1′) and herbicides containing at least one kind of these compounds as active ingredients, [wherein G is an optionally substituted nitrogen-containing heterocyclic group represented by a formula (2′) with a proviso that the number of carbons constituting the nitrogen-containing heterocycle of the nitrogen-containing heterocyclic group is 10 or less and that 2H-Indazole ring is excluded; Q′ represents cyano or the like; and A′ represents substituted phenyl or the like].

  提供了一种可能是除草剂活性成分的新型氨基脲化合物，其在较小剂量下可靠有效且高度安全，并含有这些化合物作为活性成分的除草剂。该化合物由式（1'）表示，含有至少一种这些化合物作为活性成分的除草剂，其中G是可选取代的氮杂环基团，由式（2'）表示，其中构成氮杂环的碳数不超过10，并且不包括2H-吲哚唑环；Q'代表氰基或类似物；A'代表取代的苯基或类似物。
• AMIDINE COMPOUND AND HERBICIDE
  申请人：NIPPON SODA CO., LTD.

  公开号：EP1911350A1

  公开（公告）日：2008-04-16

  Novel amidine compounds which may be active ingredients in herbicides that are reliably effective at a lesser dose and highly safe, and herbicides containing these compounds as active ingredients are provided. Amidine compounds represented by a formula (1') and herbicides containing at least one kind of these compounds as active ingredients, [wherein G is an optionally substituted nitrogen-containing heterocyclic group represented by a formula (2') with a proviso that the number of carbons constituting the nitrogen-containing heterocycle of the nitrogen-containing heterocyclic group is 10 or less and that 2H-Indazole ring is excluded; Q' represents cyano or the like; and A' represents substituted phenyl or the like].

  本发明提供了可作为除草剂活性成分的新型脒类化合物，这些化合物在较小剂量下具有可靠的有效性和高度安全性，还提供了含有这些化合物作为活性成分的除草剂。由式（1'）表示的脒化合物 以及含有至少一种此类化合物作为活性成分的除草剂，[其中 G 是由式（2'）表示的任选取代的含氮杂环基团 但条件是构成含氮杂环基团的含氮杂环的碳数为 10 或更少，且不包括 2H-Indazole 环；Q'代表氰基或类似物；A'代表取代苯基或类似物]。