3-氯-4-氧代戊酸 | 77012-53-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 中文名称: 3-氯-4-氧代戊酸
• 英文名称: 3-chloro-4-oxopentanoic acid
• 英文别名: 3-chloro-4-oxo-valeric acid；3-Chlor-4-oxo-valeriansaeure
• CAS: 77012-53-4
• 化学式: C₅H₇ClO₃
• 分子量: 150.562
• InChiKey: VDXVPHGHELUOLS-UHFFFAOYSA-N

物化性质

• 沸点：
  246.6±20.0 °C(Predicted)
• 密度：
  1.314±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2918300090

反应信息

• 作为产物：
  描述：

  乙酰丙酸 在 盐酸 、 氯 作用下， 生成 3-氯-4-氧代戊酸
  参考文献：
  名称：

  Overend et al., Journal of the Chemical Society, 1950, p. 3500,3504

  摘要：

  DOI：

文献信息

• Familial Paget's Disease of Bone: Nonlinkage to the PDB1 and PDB2 Loci on Chromosomes 6p and 18q in a Large Pedigree
  作者：David Good、Frances Busfield、David Duffy、Paul K. Lovelock、Janine B. Kesting、Donald P. Cameron、Joanne T. E. Shaw

  DOI：10.1359/jbmr.2001.16.1.33

  日期：——

  Paget's disease of bone is a common condition characterized by bone pain, deformity, pathological fracture, and an increased incidence of osteosarcoma. Genetic factors play a role in the pathogenesis of Paget's disease but the molecular basis remains largely unknown. Susceptibility loci for Paget's disease of bone have been mapped to chromosome 6p21.3 (PDB1) and 18q21.1‐q22 (PDB2) in different pedigrees. We have identified a large pedigree of over 250 individuals with 49 informative individuals affected with Paget's disease of bone; 31 of whom are available for genotypic analysis. The disease is inherited as an autosomal dominant trait in the pedigree with high penetrance by the sixth decade. Linkage analysis has been performed with markers at PDB1; these data show significant exclusion of linkage with log10 of the odds ratio (LOD) scores < −2 in this region. Linkage analysis of microsatellite markers from the PDB2 region has excluded linkage with this region, with a 30 cM exclusion region (LOD score < −2.0) centered on D18S42. These data confirm the genetic heterogeneity of Paget's disease of bone. Our hypothesis is that a novel susceptibility gene relevant to the pathogenesis of Paget's disease of bone lies elsewhere in the genome in the affected members of this pedigree and will be identified using a microsatellite genomewide scan followed by positional cloning.

  佩吉特骨病是一种常见疾病，其特征包括骨痛、畸形、病理性骨折及骨肉瘤的发生率增加。遗传因素在佩吉特骨病的发病机制中起作用，但其分子基础尚不清楚。佩吉特骨病的易感位点已在不同家系中定位于6p21.3（PDB1）和18q21.1-q22（PDB2）染色体上。我们已经识别出一个超过250人的大家系，其中49名信息量丰富的个体受佩吉特骨病影响；其中31人可用于基因型分析。该病在家系中以常染色体显性遗传，六十岁时有很高的外显率。我们对PDB1区域的标记进行了连锁分析，这些数据显示在该区域的连锁排除率显著，log10赔率比（LOD）分数小于−2。对PDB2区域微卫星标记的连锁分析也排除了与该区域的连锁，排除区域为30 cM（LOD分数小于−2.0），以D18S42为中心。这些数据确认了佩吉特骨病的遗传异质性。我们的假设是，一个与佩吉特骨病发病机制相关的新易感基因位于该家系受影响个体的基因组其他位置，并将通过微卫星全基因组扫描和后续的定位克隆技术进行识别。
• Method for obtaining 5-halogenolaevulinic acid alkyl esters
  申请人：Aldenkortt Dr Sven

  公开号：US20050070727A1

  公开（公告）日：2005-03-31

  A method for obtaining a 5-bromolevulinic acid methyl ester or a 5-chlorolevulinic acid methyl ester from either a bromination mixture or a chlorination mixture, containing either a 5-bromo-levulinic acid methyl ester or a 5-chlorolevulinic acid methyl ester, respectively, produced by either brominating or chlorinating levulinic acid or a levulinic acid methyl ester, and further including the steps of dissolving the bromination or chlorination mixture in an organic solvent or solvent mixture and cooling the solution, preferably to −20° C.-−40° C., with the 5-bromolevulinic acid methyl ester or 5-chlorolaevulinic acid methyl ester being crystallized out of the solution. The 5-bromolevulinic acid methyl ester or 5-chlorolevulinic acid is then isolated by draining off the solution with the remaining bromination mixture or chlorination mixture, as appropriate.

  从溴化混合物或氯化混合物中获取5-溴丙酮酸甲酯或5-氯丙酮酸甲酯的方法，分别包含5-溴丙酮酸甲酯或5-氯丙酮酸甲酯，这些物质是通过溴化或氯化丙酮酸或丙酮酸甲酯产生的。进一步包括将溴化或氯化混合物溶解在有机溶剂或溶剂混合物中，并冷却溶液，最好冷却至-20°C至-40°C，其中5-溴丙酮酸甲酯或5-氯丙酮酸甲酯从溶液中结晶出来。然后通过排出剩余的溴化混合物或氯化混合物，分离出5-溴丙酮酸甲酯或5-氯丙酮酸甲酯。
• A METHOD FOR THE PRODUCTION OF LEVULINIC ACID AND ITS DERIVATIVES
  申请人：Arkenol, Inc.

  公开号：EP0937024A1

  公开（公告）日：1999-08-25
• COMPOSITIONS AND RELATED METHODS FOR AGRICULTURE
  申请人：Flagship Pioneering Innovations V, Inc.

  公开号：US20210289794A1

  公开（公告）日：2021-09-23

  The invention comprises methods for decreasing colonization by a bacterium of a gut of a stink bug, the method comprising providing a composition comprising vanillin or an analog thereof; and delivering said composition to an egg from which the stink bug will hatch, whereby colonization by the bacterium within the gut of the stink bug hatched from the egg treated with the composition is decreased relative to a stink bug hatched from an untreated egg. In some embodiments, the decrease in colonization by the bacterium decreases the fitness of the stink bug, e.g., decreases reproductive ability, survival, rate of development, number of eggs, number of hatched eggs, adult emergence rate, body length, body width, body mass, or cuticle thickness. In some embodiments of the methods herein, the bacterial colonization-disrupting agent is an inhibitor of bacterial metabolism. In some embodiments, the bacterial colonization-disrupting agent is a polyhydroxyalkanoate (PHA) synthesis inhibitor.
• US5892107A
  申请人：——

  公开号：US5892107A

  公开（公告）日：1999-04-06