2-亚甲基癸酸乙酯 | 78640-23-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2-亚甲基癸酸乙酯
• 英文名称: ethyl 2-methylenedecanoate
• 英文别名: Ethyl 2-methylidenedecanoate
• CAS: 78640-23-0
• 化学式: C₁₃H₂₄O₂
• 分子量: 212.332
• InChiKey: MTZZFQSWPBCXOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  15
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-亚甲基癸酸乙酯 在 二异丁基氢化铝 作用下， 以94%的产率得到2-methylenedecan-1-ol
  参考文献：
  名称：

  Dipodal ligands from chiral spiro[2.4]hepta-4,6-dienes: solid state conformational effects by tether substitution in dipodal η5,η1-CpP–ruthenium(II) complexes

  摘要：

  New chiral spiro[2.4]hepta-4,6-dienes were prepared and used in an efficient synthesis of cyclopentadienyl ruthenium complexes with pendant phosphine donors. Solid state structures reveal a conformation trend among three structurally homologous complexes that involves subtle twisting about the tether with increasing substitution at the alpha carbon. These results suggest architectural requirements for future ligand designs. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)01323-6
• 作为产物：
  描述：

  辛基丙二酸二乙酯 在 哌啶 、 氢氧化钾 作用下， 以 吡啶 、 乙醇 为溶剂， 生成 2-亚甲基癸酸乙酯
  参考文献：
  名称：

  Dipodal ligands from chiral spiro[2.4]hepta-4,6-dienes: solid state conformational effects by tether substitution in dipodal η5,η1-CpP–ruthenium(II) complexes

  摘要：

  New chiral spiro[2.4]hepta-4,6-dienes were prepared and used in an efficient synthesis of cyclopentadienyl ruthenium complexes with pendant phosphine donors. Solid state structures reveal a conformation trend among three structurally homologous complexes that involves subtle twisting about the tether with increasing substitution at the alpha carbon. These results suggest architectural requirements for future ligand designs. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)01323-6

文献信息

• N-Heterocyclic Carbene Catalyzed Umpolung of Michael Acceptors for Intermolecular Reactions
  作者：Akkattu T. Biju、Mohan Padmanaban、Nathalie E. Wurz、Frank Glorius

  DOI：10.1002/anie.201103555

  日期：2011.8.29

  leahciM! The N‐heterocyclic carbene catalyzed umpolung of Michael acceptors proceeds through the formation of a deoxy‐Breslow intermediate (see scheme; EWG=electron‐withdrawing group). This nucleophilic species can react with other Michael acceptors in an intermolecular fashion, thereby resulting in the formation of homo‐ or heterodimeric olefins. This “Michael umpolung” should become a valuable method

  漏气！N杂环卡宾催化的Michael受体的化合物通过形成脱氧Breslow中间体进行（参见方案； EWG =吸电子基团）。这种亲核物质可以分子间方式与其他迈克尔受体反应，从而导致形成同二聚或异二聚烯烃。这种“ Michael umpolung”应该成为形成致密官能化烯烃的一种有价值的方法。
• Studies on angiotensin converting enzyme inhibitors. III. 2-Carboxyethylcarbamoyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives.
  作者：KIMIAKI HAYASHI、KENICHI NUNAMI、KAZUO SAKAI、YASUHIKO OZAKI、JYOJI KATO、KEIZO KINASHI、NAOTO YONEDA

  DOI：10.1248/cpb.33.2011

  日期：——

  (3S)-2-[N-Substituted N-(2-carboxyethyl) carbamoyl]-1, 2, 3, 4-tetrahydroisoquinoline-3-carboxylic acid derivaties (8a-d and 12a-t) and their monoester compounds (13a-k) were synthesized by condensation of (3S)-1, 2, 3, 4-tetrahydroisoquinoline-3-carboxylates (6a, b), 3-aminopropionates (5a, b or 10a-m) and phosgene, followed by deprotection of ester groups. Their in vitro angiotensin converting enzyme (ACE) inhibitory activities and antihypertensive effects were evaluated, and the structure-activity relationship is discussed. Some of the N-ethylcarbamoyl analogs (12h, 12j, 12k, 12l and 12o), which had hydrophobic substituents (C8H17-C12H25, CH2CH2Ph) at the α-position to the carboxyl group in the side chain, showed potent in vitro ACE inhibitory activities with IC50 values of 4.0-8.8×10-9M. The monoesters 13e, 13h, and 13i reduced the systolic blood pressure by more than 30 mmHg in spontaneously hypertensive rats (SHR) at an oral dose of 50mg/kg.

  (3S)-2-[N-取代的N-(2-羧乙基)氨基甲酸]-1, 2, 3, 4-四氢异喹啉-3-羧酸衍生物 (8a-d 和 12a-t) 及其单酯化合物 (13a-k) 通过 (3S)-1, 2, 3, 4-四氢异喹啉-3-羧酸酯 (6a, b)、3-氨基丙酸酯 (5a, b 或 10a-m) 和氯仿的缩合反应合成，随后去保护酯基。评估了它们在体外的血管紧张素转化酶 (ACE) 抑制活性及抗高血压效果，并讨论了结构-活性关系。一些具有疏水取代基（C8H17-C12H25，CH2CH2Ph）在侧链α位与羧基相邻的N-乙基氨基甲酸类似物 (12h, 12j, 12k, 12l 和 12o) 显示出强大的体外ACE抑制活性，IC50值为4.0-8.8×10^-9M。单酯化合物13e、13h和13i在口服剂量为50mg/kg时，能使自发性高血压大鼠 (SHR) 的收缩压下降超过30 mmHg。
• Image bearing member, method of manufacturing the same, image formation method, image forming apparatus and process cartridge
  申请人：Nagai Kazukiyo

  公开号：US20080304867A1

  公开（公告）日：2008-12-11

  An image bearing member including an electroconductive substrate, a photosensitive layer located overlying the electroconductive substrate and a cross linking surface layer comprising a charge transport curing compound and located overlying the photosensitive layer, wherein the charge transport curing compound includes a material including a structure unit represented by the following Chemical formula A: Chemical formula A where R 1 to R 5 and R 1 ′ to R 5 ′ independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms, R 6 represents a hydrogen atom or a methyl group and X represents an alkylene group having a straight chain or a branched chain having 2 to 5 carbon atoms.

  一种图像承载成员，包括导电基底、位于导电基底上方的感光层和包括电荷传输固化化合物、位于感光层上方的交联表面层，其中电荷传输固化化合物包括一种材料，该材料包括以下化学式A所表示的结构单元： 化学式A 其中R1至R5和R1'至R5'独立地表示氢原子、具有1至4个碳原子的烷基或具有1至4个碳原子的烷氧基，R6表示氢原子或甲基基团，X表示具有2至5个碳原子的直链或支链烷基。
• ACRYLIC ESTER COMPOUND AND MANUFACTURING INTERMEDIATE THEREOF, METHOD FOR MANUFACTURING ACRYLIC ESTER COMPOUND, AND LATENT ELECTROSTATIC IMAGE BEARING MEMBER, IMAGE FORMING METHOD, IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE
  申请人：HORIUCHI Tamotsu

  公开号：US20110287353A1

  公开（公告）日：2011-11-24

  To provide: a latent electrostatic image bearing member including one of a cured material obtained through radical polymerization of a radically polymerizable compound of component (A1), and a cured material obtained through radical polymerization of a radically polymerizable compound of component (A2) in the outermost layer, wherein the component (A1) includes two radically polymerizable groups and a substituted amino group which does not include a radically polymerizable group in a molecule, and the radically polymerizable group and the nearest substituted amino group which does not include an unsaturated bond in between are connected with two or more aromatic hydrocarbon compounds, and, the radically polymerizable compound of component (A2) includes a condensed polycyclic aromatic hydrocarbon formed by bonding a radically polymerizable group and a non-radically polymerizable substituted amine group through a condensed polycyclic aromatic hydrocarbon group; and an image forming apparatus, image forming method and process cartridge which uses thereof.

  提供一种潜在的静电图像承载成员，包括通过组分（A1）的自由基聚合获得的固化材料之一，以及在最外层通过组分（A2）的自由基聚合获得的固化材料，其中组分（A1）包括两个自由基聚合基团和一个分子中不包含自由基聚合基团的取代氨基团，并且最近的不包含不饱和键的取代氨基团与自由基聚合基团之间连接有两个或更多芳香族碳氢化合物，而组分（A2）的自由基聚合化合物包括通过连接一个自由基聚合基团和一个非自由基聚合取代胺基团的环状多环芳香族碳氢化合物形成的缩聚多环芳香族碳氢化合物；以及使用该承载成员的图像形成设备、图像形成方法和处理盒。
• Molecular Healing of Polymeric Materials, Coatings, Plastics, Elastomers, Composites, Laminates, Adhesives, and Sealants by Active Enzymes
  申请人：McDaniel C. Steven

  公开号：US20100210745A1

  公开（公告）日：2010-08-19

  Disclosed herein are polymeric materials such as a coating, a plastic, a laminate, a composite, an elastomer, an adhesive, or a sealant; a surface treatment such as a textile finish or a wax; a filler for such a polymeric material or a surface treatment that includes an enzyme such as an esterase (e.g., a lipolytic enzyme, a sulfuric ester hydrolase, an organophosphorus compound degradation enzyme), an enzyme (e.g., a lysozyme, a lytic transglycosylase) that degrades a cell wall and/or a cell membrane component, a biocidal or biostatic peotide, and/or a peptidase. Also disclosed herein are methods of altering a material's property such as service life, flexability, or rigidity, by incorporation of an enzyme into a material capable of being chemically crosslinked by the activity of a lipolytic enzyme, a hydrolase, and/or a urease.

  本文公开了一些聚合材料，如涂层、塑料、层压板、复合材料、弹性体、粘合剂或密封剂；一种表面处理，如纺织品涂层或蜡；一种填料，用于这样的聚合材料或表面处理，其中包括一种酶，如酯酶（例如，脂肪水解酶，硫酸酯水解酶，有机磷化合物降解酶），降解细胞壁和/或细胞膜成分的酶（例如，溶菌酶，裂解转糖基酶），生物杀菌或生物静态肽，以及/或肽酶。本文还公开了通过将酶纳入可通过脂肪水解酶、水解酶和/或脲酶的活性交联材料中来改变材料性能，如使用寿命、柔韧性或刚度的方法。