isobilianic acid | 475-30-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: isobilianic acid
• 英文别名: Isobiliansaeure；7.12-Dioxo-2.3-seco-5β-cholantrisaeure-(2.3.24)；(4R)-4-[(3R,3aR,5aS,6S,7R,9aR,9bS)-6,7-bis(carboxymethyl)-3a,6-dimethyl-4,9-dioxo-2,3,5,5a,7,8,9a,9b-octahydro-1H-cyclopenta[a]naphthalen-3-yl]pentanoic acid
• CAS: 475-30-9
• 化学式: C₂₄H₃₄O₈
• 分子量: 450.529
• InChiKey: GMDKYYHRWSPTAY-MIQNBYDESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.27
• 重原子数：
  32.0
• 可旋转键数：
  8.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  146.04
• 氢给体数：
  3.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  isobilianic acid 在 盐酸 、 amalgamated zinc 、 溶剂黄146 作用下， 生成 12-oxo-2,3-seco-5β-cholanetrioic acid-(2.3.24)
  参考文献：
  名称：

  Borsche; Rosenkranz, Chemische Berichte, 1919, vol. 52, p. 342,344

  摘要：

  DOI：
• 作为产物：
  描述：

  胆酸 在 potassium dichromate 、 硫酸 作用下， 生成 bilianic acid 、 isobilianic acid
  参考文献：
  名称：

  Latschinoff, Chemische Berichte, 1886, vol. 19, p. 1529,1530

  摘要：

  DOI：

文献信息

• Effect of scleral expansion band on ocular hypertension: Canadian phase 1 study
  作者：Aaron W. Rifkind、Michael E. Yablonski、Jonathan J. Shuster

  DOI：10.1007/s12019-001-0032-2

  日期：2001.12

  A prospective, nonrandomized, controlled, phase 1 clinical trial was conducted to evaluate use of the scleral expansion band for lowering elevated intraocular pressure (IOP) in patients with ocular hypertension or primary open-angle glaucoma. The procedure lowered IOP by increasing outflow.

  我们进行了一项前瞻性、非随机对照的一期临床试验，以评估巩膜扩张带对降低眼压过高或原发性开角型青光眼患者眼压的作用。该手术通过增加眼球外流来降低眼压。
• Borsche; Hallwass, Chemische Berichte, 1922, vol. 55, p. 3318,3323
  作者：Borsche、Hallwass

  DOI：——

  日期：——
• Mylius, Chemische Berichte, 1887, vol. 20, p. 1968,1981
  作者：Mylius

  DOI：——

  日期：——
• Borsche; Morrison, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1931, vol. 198, p. 165,177
  作者：Borsche、Morrison

  DOI：——

  日期：——
• Geometrical entropies. The extended entropy
  作者：J.M. Zoido、F. Carreño

  DOI：10.1007/s100510070125

  日期：2000.10

  By taking into account a geometrical interpretation of the measurement process [1,2], we define a set of measures of uncertainty. These measures will be called geometrical entropies. The amount of information is defined by considering the metric structure in the probability space. Shannon-von Neumann entropy is a particular element of this set. We show the incompatibility between this element and the concept of variance as a measure of the statistical fluctuations. When the probability space is endowed with the generalized statistical distance proposed in reference [3], we obtain the extended entropy. This element, which belongs to the set of geometrical entropies: is fully compatible with the concept of variance. Shannon-von Neumann entropy is recovered as an approximation of the extended entropy. The behavior of both entropies is compared in the case of a particle in a square-well potential.