(5R)-5-[3-(1,2:4,5-di-O-isopropylidene-β-D-psicopyranosyloxy)]-3-(3,4,5-trimethoxyphenyl)-4,5-dihydroisoxazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧吡喃
• 英文名称: (5R)-5-[3-(1,2:4,5-di-O-isopropylidene-β-D-psicopyranosyloxy)]-3-(3,4,5-trimethoxyphenyl)-4,5-dihydroisoxazole
• 英文别名: (5R)-5-[(3'aR,4S,7'R,7'aR)-2,2,2',2'-tetramethylspiro[1,3-dioxolane-4,6'-3a,4,7,7a-tetrahydro-[1,3]dioxolo[4,5-c]pyran]-7'-yl]oxy-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1,2-oxazole
• 化学式: C₂₄H₃₃NO₁₀
• 分子量: 495.527
• InChiKey: AIVNSCQQEGZGSG-DMCJJKJGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  105
• 氢给体数：
  0
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  3,4,5-三甲氧基苯甲醛肟 在 吡啶 、 N-氯代丁二酰亚胺 、 三乙胺 作用下， 以 氯仿 为溶剂， 反应 4.0h， 生成 (5R)-5-[3-(1,2:4,5-di-O-isopropylidene-β-D-psicopyranosyloxy)]-3-(3,4,5-trimethoxyphenyl)-4,5-dihydroisoxazole
  参考文献：
  名称：

  Sugar-based ethenyl ethers: stereoselective dipolar cycloadditions of nitrile oxides

  摘要：

  Selected sugar-based ethenyl ethers have been employed in 1,3-dipolar cycloaddition with nitrite oxides. In the D-fructo series, high diastercoselectivity was observed as compared with the 3-epimeriC D-psico series. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(02)00709-7

文献信息

• Sugar-based ethenyl ethers: stereoselective dipolar cycloadditions of nitrile oxides
  作者：Matthieu Desroses、Florence Chéry、Arnaud Tatibouët、Ottorino De Lucchi、Patrick Rollin

  DOI：10.1016/s0957-4166(02)00709-7

  日期：2002.11

  Selected sugar-based ethenyl ethers have been employed in 1,3-dipolar cycloaddition with nitrite oxides. In the D-fructo series, high diastercoselectivity was observed as compared with the 3-epimeriC D-psico series. (C) 2002 Elsevier Science Ltd. All rights reserved.