1-cyclopropyl-5-methyl-4-hexenol | 134721-00-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1-cyclopropyl-5-methyl-4-hexenol
• 英文别名: 1-Cyclopropyl-5-methylhex-4-en-1-ol
• CAS: 134721-00-9
• 化学式: C₁₀H₁₈O
• 分子量: 154.252
• InChiKey: DIZDSBDDMANXOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  甲酸 、 1-cyclopropyl-5-methyl-4-hexenol 以 四氢呋喃 为溶剂， 反应 0.5h， 以80%的产率得到1-cyclopropyl-5-methyl-4-hexenyl formate
  参考文献：
  名称：

  Formolysis and acetolysis of linear saturated and allylic secondary cyclopropyl carbinols

  摘要：

  Simple esterification of a series of secondary aliphatic cyclopropyl carbinols under the influence of concentrated HCO2H or AcOH without modification of the carbon skeleton is disclosed. Under the same conditions related allyl alcohols undergo stereospecific isomerization to the corresponding esters of 3E,5E-dienols.

  DOI：

  10.1007/bf00958566
• 作为产物：
  描述：

  1-环丙基-5-甲基-4-己烯-1-酮 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 0.5h， 以92%的产率得到1-cyclopropyl-5-methyl-4-hexenol
  参考文献：
  名称：

  Formolysis and acetolysis of linear saturated and allylic secondary cyclopropyl carbinols

  摘要：

  Simple esterification of a series of secondary aliphatic cyclopropyl carbinols under the influence of concentrated HCO2H or AcOH without modification of the carbon skeleton is disclosed. Under the same conditions related allyl alcohols undergo stereospecific isomerization to the corresponding esters of 3E,5E-dienols.

  DOI：

  10.1007/bf00958566

文献信息

• Stereoselective Synthesis of<i>cis</i>-2,5-Disubstituted Pyrrolidines via Copper-Catalyzed Cyclization of Alkenes
  作者：Sai-Hu Cai、Bing-Chao Da、Jia-Hui Zhou、Yun-He Xu、Teck-Peng Loh

  DOI：10.1002/cjoc.201600380

  日期：2016.11

  An efficient methodology for the stereoselective synthesis of cis‐2,5‐disubstituted pyrrolidines using copper catalyst was developed. The corresponding cis‐2,5‐disubstituted pyrrolidines could be obtained in reasonable yields and with good stereoselectivities in the presence of 4,4′‐di‐tert‐butyl‐2,2′‐bipyridine as ligand and 1‐methyl‐2‐pyrrolidinone as solvent.

  开发了一种使用铜催化剂立体选择性合成顺式-2,5-二取代吡咯烷的有效方法。在4,4'-二叔丁基-2,2'-联吡啶作为配体和1-甲基-2-基吡啶存在下，可以以合理的收率和良好的立体选择性获得相应的顺式-2,5-二取代的吡咯烷。吡咯烷酮作为溶剂。
• CHESKIS, B. A.;IVANOVA, N. M.;MOISEENKOV, A. M., IZV. AN CCCP. CEP. XIM.,(1991) N, S. 853-856
  作者：CHESKIS, B. A.、IVANOVA, N. M.、MOISEENKOV, A. M.

  DOI：——

  日期：——
• Formolysis and acetolysis of linear saturated and allylic secondary cyclopropyl carbinols
  作者：B. A. Cheskis、N. M. Ivanova、A. M. Moiseenkov

  DOI：10.1007/bf00958566

  日期：1991.4

  Simple esterification of a series of secondary aliphatic cyclopropyl carbinols under the influence of concentrated HCO2H or AcOH without modification of the carbon skeleton is disclosed. Under the same conditions related allyl alcohols undergo stereospecific isomerization to the corresponding esters of 3E,5E-dienols.