(NH2CH2C(CH3)2CH2NH2)dihydroxoplatinum(II) | 871562-53-7

• 分子结构分类: 有机化合物 - 碳氢化合物
• 英文名称: (NH2CH2C(CH3)2CH2NH2)dihydroxoplatinum(II)
• CAS: 871562-53-7
• 化学式: C₅H₁₆N₂O₂Pt
• 分子量: 331.274
• InChiKey: JLLQNDQJZFFNBM-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  (NH2CH2C(CH3)2CH2NH2)dihydroxoplatinum(II) 在 sodium chloride 作用下， 以 高氯酸 为溶剂， 生成 [Pt(2,2-dimethyl-1,3-propylenediamine)Cl₂]
  参考文献：
  名称：

  The hydrolysis products of cis-diamminedichloroplatinum(II) 6. A kinetic comparison of the cis- and trans-isomers and other cis-di(amine)di(chloro)platinum(II) compounds

  摘要：

  Di(amine)di(chloro)platinum(II) complexes react in aqueous acid solution to form an equilibrium mixture L2PtCl2 k-1 reversible kj L2PtCl(OH2)+ + Cl-. Values of k1, K-1 and the equilibrium constant K(T) (-k1/k-1) have been measured for the systems L2 = cis(NH3)2, trans(NH3)2, cis(py)2, en, RR-chxn, tn and Me2tn, with varying temperature and ionic strength (cis(NH3)2 only). At 25-degrees-C and I = 0.1 M, data for cis-PtCl2(NH3)2 are k1 = 5.18 x 10(-5) s-1 (DELTA-H# = 86.7 kJ mol-1, DELTA-S# = -36 J K mol-1), k1 = 7.68 x 10(-3) M-1 s-1 (DELTA-H# - 72.7, DELTA-S# = - 41) and K1 = 6.74 x 10(-3). Corresponding data for trans-PtCl2(NH3)2 are k1 = 1.90 x 10(-5) s-1 (DELTA-H# = 92.2, DELTA-S# = - 26), k-1 - 3.05 x 10(-2) M-1 s-1 (DELTA-H# = 85.7, DELTA-S# = + 14) and K1 = 6.22 x 10(-4). These data provide a kinetic explanation for the inactivity of the trans-isomer as an anti-cancer drug.

  DOI：

  10.1016/s0020-1693(00)80242-x
• 作为产物：
  描述：

  [Pt(2,2-dimethyl-1,3-propylenediamine)Cl₂] 在 sodium hydroxide 作用下， 以 水 为溶剂， 生成 (NH2CH2C(CH3)2CH2NH2)dihydroxoplatinum(II)
  参考文献：
  名称：

  The hydrolysis products of cis-diamminedichloroplatinum(II) 6. A kinetic comparison of the cis- and trans-isomers and other cis-di(amine)di(chloro)platinum(II) compounds

  摘要：

  Di(amine)di(chloro)platinum(II) complexes react in aqueous acid solution to form an equilibrium mixture L2PtCl2 k-1 reversible kj L2PtCl(OH2)+ + Cl-. Values of k1, K-1 and the equilibrium constant K(T) (-k1/k-1) have been measured for the systems L2 = cis(NH3)2, trans(NH3)2, cis(py)2, en, RR-chxn, tn and Me2tn, with varying temperature and ionic strength (cis(NH3)2 only). At 25-degrees-C and I = 0.1 M, data for cis-PtCl2(NH3)2 are k1 = 5.18 x 10(-5) s-1 (DELTA-H# = 86.7 kJ mol-1, DELTA-S# = -36 J K mol-1), k1 = 7.68 x 10(-3) M-1 s-1 (DELTA-H# - 72.7, DELTA-S# = - 41) and K1 = 6.74 x 10(-3). Corresponding data for trans-PtCl2(NH3)2 are k1 = 1.90 x 10(-5) s-1 (DELTA-H# = 92.2, DELTA-S# = - 26), k-1 - 3.05 x 10(-2) M-1 s-1 (DELTA-H# = 85.7, DELTA-S# = + 14) and K1 = 6.22 x 10(-4). These data provide a kinetic explanation for the inactivity of the trans-isomer as an anti-cancer drug.

  DOI：

  10.1016/s0020-1693(00)80242-x

文献信息

• The hydrolysis products of cis-diamminedichloroplatinum(II) 8. Kinetics of the base hydrolysis of PtCl2(AA) (AA=en, chxn, Tn, Me2tn) and trans-PtCl2(NH3)2
  作者：Carol J. Abraham、Kathryn J. Gerard、Donald A. House

  DOI：10.1016/s0020-1693(00)85131-2

  日期：1993.7