3-(4-hydroxyphenyl)-1-naphthalen-1-ylprop-2-en-1-one | 38132-63-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 3-(4-hydroxyphenyl)-1-naphthalen-1-ylprop-2-en-1-one
• CAS: 38132-63-7
• 化学式: C₁₉H₁₄O₂
• 分子量: 274.319
• InChiKey: CITAWYJDGHUQSO-UHFFFAOYSA-N

物化性质

• 沸点：
  485.7±37.0 °C(Predicted)
• 密度：
  1.233±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.44
• 重原子数：
  21.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.3
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  3-(4-hydroxyphenyl)-1-naphthalen-1-ylprop-2-en-1-one 、 尿素 在 10% phosphoric acid on silica 作用下， 以 neat (no solvent) 为溶剂， 以91%的产率得到
  参考文献：
  名称：

  SOLID SiO2-H3PO4 IS AN EFFICIENT CATALYST FOR CYCLIZATION OF ENONES UNDER SOLVENT-FREE CONDITION: SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF SOME OXAZINE DERIVATIVES

  摘要：

  A series of some 1, 3-oxazine amine derivatives including 4-(1-naphthyl)-5,6-dihydro-6-(substituted phenyl)-oxazine-2-amines has been synthesised by lsolid SiO2-H3PO4 catalyzed solvent-free cyclization of aryl chalcones and urea under microwave irradiation. The yields of the oxazines were more than 80%. The synthesised oxazine amines were characterized by their physical constants, analytical and spectroscopic data. The antimicrobial activities of these oxazine derivatives have been studied using Bauer-Kirby method.

  DOI：

  10.4067/s0717-97072014000300011