tert-butyl (2S,5S,6S)-2-((S)-((3aR,4S,6R,6aR)-6-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)((triethylsilyl)oxy)methyl)-1,4-dimethyl-3-oxo-6-((triethylsilyl)oxy)-1,4-diazepane-5-carboxylate | 1037307-63-3

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: tert-butyl (2S,5S,6S)-2-((S)-((3aR,4S,6R,6aR)-6-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)((triethylsilyl)oxy)methyl)-1,4-dimethyl-3-oxo-6-((triethylsilyl)oxy)-1,4-diazepane-5-carboxylate
• CAS: 1037307-63-3
• 化学式: C₃₆H₆₄N₄O₁₀Si₂
• 分子量: 769.096
• InChiKey: JPQQPLSAVJBUFS-NRPUIPRYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.22
• 重原子数：
  52.0
• 可旋转键数：
  14.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  150.86
• 氢给体数：
  1.0
• 氢受体数：
  12.0

反应信息

• 作为反应物：
  描述：

  tert-butyl (2S,5S,6S)-2-((S)-((3aR,4S,6R,6aR)-6-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)((triethylsilyl)oxy)methyl)-1,4-dimethyl-3-oxo-6-((triethylsilyl)oxy)-1,4-diazepane-5-carboxylate 在 四丁基氟化铵 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以51%的产率得到tert-butyl (2S,5S,6S)-2-((S)-((3aR,4R,6R,6aR)-6-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)(hydroxy)methyl)-6-hydroxy-1,4-dimethyl-3-oxo-1,4-diazepane-5-carboxylate
  参考文献：
  名称：

  Structure–activity relationship of truncated analogs of caprazamycins as potential anti-tuberculosis agents

  摘要：

  Systematic structure-activity relationship studies of caprazamycin (CPZ) analogs, including the aminoribose-truncated 5 and the uridine-truncated 6, have been carried out. Both 5 and 6 were synthesized efficiently via diazepanone ring construction by intramolecular reductive alkylation of aminoaldehyde derivatives. The antibacterial activity of a range of analogs, including 5 and 6, against Mycobacteriumosis was evaluated, and it was found that the uridine, the aminoribose, and the fatty acyl side chains are crucial for antibacterial activity. This study would be a guide for designing novel anti-tuberculosis agents based on the 6'-N-alkyl-5'-beta-O-aminoribosyl-glycyluridine class of antibiotics including the CPZs. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.03.020
• 作为产物：
  描述：

  tert-butyl (2S,5S,6S)-2-((S)-((3aR,4R,6R,6aR)-6-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)(hydroxy)methyl)-6-hydroxy-1,4-dimethyl-3-oxo-1,4-diazepane-5-carboxylate 、 三乙基硅基三氟甲磺酸酯 生成 tert-butyl (2S,5S,6S)-2-((S)-((3aR,4S,6R,6aR)-6-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)((triethylsilyl)oxy)methyl)-1,4-dimethyl-3-oxo-6-((triethylsilyl)oxy)-1,4-diazepane-5-carboxylate
  参考文献：
  名称：

  Structure–activity relationship of truncated analogs of caprazamycins as potential anti-tuberculosis agents

  摘要：

  Systematic structure-activity relationship studies of caprazamycin (CPZ) analogs, including the aminoribose-truncated 5 and the uridine-truncated 6, have been carried out. Both 5 and 6 were synthesized efficiently via diazepanone ring construction by intramolecular reductive alkylation of aminoaldehyde derivatives. The antibacterial activity of a range of analogs, including 5 and 6, against Mycobacteriumosis was evaluated, and it was found that the uridine, the aminoribose, and the fatty acyl side chains are crucial for antibacterial activity. This study would be a guide for designing novel anti-tuberculosis agents based on the 6'-N-alkyl-5'-beta-O-aminoribosyl-glycyluridine class of antibiotics including the CPZs. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.03.020