4-(2-methoxyethyl)-4H-1,2,4-triazole | 1282494-77-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(2-methoxyethyl)-4H-1,2,4-triazole
• 英文别名: 4-methoxyethyl-1,2,4-triazole；4-(2-Methoxyethyl)-4H-1,2,4-triazole；4-(2-methoxyethyl)-1,2,4-triazole
• CAS: 1282494-77-2
• 化学式: C₅H₉N₃O
• 分子量: 127.146
• InChiKey: CAWVKDYGVBLBME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  39.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(2-methoxyethyl)-4H-1,2,4-triazole 在 甲醇 、 sodium tetrahydroborate 、 三氯氧磷 作用下， 反应 18.5h， 生成 (4-(2-methoxyethyl)-4H-1,2,4-triazol-3-yl)methanol
  参考文献：
  名称：

  [EN] HETEROCYCLIC GLP-1 AGONISTS
  [FR] AGONISTES HÉTÉROCYCLIQUES DE GLP-1

  摘要：

  这项披露涉及到Formula (I)的GLP-1激动剂，包括其药用可接受的盐和溶剂化合物，以及包括这些化合物的药物组合物。

  公开号：

  WO2022028572A1
• 作为产物：
  描述：

  (E)-N'-{[(1E)-2-(dimethylamino)ethenyl]amino}-N,N-dimethylmethanimidamide 、 2-甲氧基乙胺 以 甲苯 为溶剂， 反应 16.0h， 生成 4-(2-methoxyethyl)-4H-1,2,4-triazole
  参考文献：
  名称：

  [EN] HETEROCYCLIC GLP-1 AGONISTS
  [FR] AGONISTES HÉTÉROCYCLIQUES DE GLP-1

  摘要：

  这项披露涉及到Formula (I)的GLP-1激动剂，包括其药用可接受的盐和溶剂化合物，以及包括这些化合物的药物组合物。

  公开号：

  WO2022028572A1

文献信息

• Calorimetric Investigation of Triazole-Bridged Fe(II) Spin-Crossover One-Dimensional Materials: Measuring the Cooperativity
  作者：Olivier Roubeau、Miguel Castro、Ramón Burriel、Jaap G. Haasnoot、Jan Reedijk

  DOI：10.1021/jp109489g

  日期：2011.3.31

  The relevance of abrupt magnetic and optical transitions exhibiting bistability in spin-crossover solids has been pointed out for their potential applications in optical or memory devices. In this respect, triazole-based one-dimensional coordination polymers are widely recognized as one of the most interesting systems. The measure of the interaction among spin-crossover centers at the origin of such cooperative behavior is of paramount importance and has so far been realized, through modeling of spin-crossover curves derived mostly from magnetic measurements. Here, a new series of triazole-based one-dimensional coordination polymers of formula [Fe(Rtrz)(3)](A)(2)center dot xH(2)O with R = methoxyethyl and A = monovalent anion has been prepared that show complete and abrupt spin-crossover phenomenon as shown by magnetic measurements. The spin-crossover transition in these and related compounds is studied by differential scanning calorimetry, and, the thermodynamic excess enthalpies and entropies associated with the phenomenon are derived systematically. Then the cooperative character of the spin-cross over in these materials is quantified by use of two widely used models, so-called Slichter and Drickamer and domain models. The same procedure is applied to spin-crossover curves of similar compounds available in the literature and for which calorimetric studies have been reported. The experimental thermodynamic figures, in particular the excess enthalpies, are shown to be clearly correlated to the output parameters of both models, thus providing a direct, experimental, quantitative measure of the cooperative character of the spin-crossover phenomenon.
• [EN] HETEROCYCLIC GLP-1 AGONISTS<br/>[FR] AGONISTES HÉTÉROCYCLIQUES DE GLP-1
  申请人：GASHERBRUM BIO INC

  公开号：WO2022028572A1

  公开（公告）日：2022-02-10

  This disclosure relates to GLP-1 agonists of Formula (I), including pharmaceutically acceptable salts and solvates thereof, and pharmaceutical compositions including the same.

  这项披露涉及到Formula (I)的GLP-1激动剂，包括其药用可接受的盐和溶剂化合物，以及包括这些化合物的药物组合物。