[4-[3,5-Bis[[3-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]-5-prop-2-ynoxyphenyl]methoxy]phenyl]-3-[2-[2-[2-[2-[2-[2-(2,4-dinitrophenoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-5-prop-2-ynoxyphenyl]methanol | 1547294-35-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [4-[3,5-Bis[[3-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]-5-prop-2-ynoxyphenyl]methoxy]phenyl]-3-[2-[2-[2-[2-[2-[2-(2,4-dinitrophenoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-5-prop-2-ynoxyphenyl]methanol
• 英文别名: [4-[3,5-bis[[3-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]-5-prop-2-ynoxyphenyl]methoxy]phenyl]-3-[2-[2-[2-[2-[2-[2-(2,4-dinitrophenoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-5-prop-2-ynoxyphenyl]methanol
• CAS: 1547294-35-8
• 化学式: C₇₆H₁₀₀N₂O₂₉
• 分子量: 1505.63
• InChiKey: KPNGQWRCDNRWBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  107
• 可旋转键数：
  66
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  333
• 氢给体数：
  1
• 氢受体数：
  29

反应信息

• 作为反应物：
  描述：

  4-methylcoumarin-7-oxymethyl 6-azidohexanoate 、 [4-[3,5-Bis[[3-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]-5-prop-2-ynoxyphenyl]methoxy]phenyl]-3-[2-[2-[2-[2-[2-[2-(2,4-dinitrophenoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-5-prop-2-ynoxyphenyl]methanol 在 copper(ll) sulfate pentahydrate 、 sodium ascorbate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 12.0h， 以54%的产率得到(4-Methyl-2-oxochromen-7-yl)oxymethyl 6-[4-[[3-[[3-[2-[2-[2-[2-[2-[2-[2-(2,4-dinitrophenoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-4-(hydroxymethyl)-6-[[1-[6-[(4-methyl-2-oxochromen-7-yl)oxymethoxy]-6-oxohexyl]triazol-4-yl]methoxy]phenyl]-5-[[3-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]-5-[[1-[6-[(4-methyl-2-oxochromen-7-yl)oxymethoxy]-6-oxohexyl]triazol-4-yl]methoxy]phenyl]methoxy]phenoxy]methyl]-5-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]phenoxy]methyl]triazol-1-yl]hexanoate
  参考文献：
  名称：

  Protein AND Enzyme Gated Supramolecular Disassembly

  摘要：

  An amphiphilic nanoassembly was designed to respond to the concurrent presence of a protein and an enzyme. We present herein a system, where in the presence of these two stimuli supramolecular disassembly and molecular release occur. This molecular release arises in the form a fluorescence response that has been shown to be specific. We also show that this system can be modified to respond only if light stimulus is also present in addition to the protein and the enzyme. Demonstration of such supramolecular disassembly principles could have broad implications in a variety of biological applications.

  DOI：

  10.1021/ja4108676
• 作为产物：
  描述：

  1-(Bromomethyl)-3-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]-5-prop-2-ynoxybenzene 、 在 18-冠醚-6 、 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 12.0h， 以38%的产率得到[4-[3,5-Bis[[3-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]-5-prop-2-ynoxyphenyl]methoxy]phenyl]-3-[2-[2-[2-[2-[2-[2-(2,4-dinitrophenoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-5-prop-2-ynoxyphenyl]methanol
  参考文献：
  名称：

  Protein AND Enzyme Gated Supramolecular Disassembly

  摘要：

  An amphiphilic nanoassembly was designed to respond to the concurrent presence of a protein and an enzyme. We present herein a system, where in the presence of these two stimuli supramolecular disassembly and molecular release occur. This molecular release arises in the form a fluorescence response that has been shown to be specific. We also show that this system can be modified to respond only if light stimulus is also present in addition to the protein and the enzyme. Demonstration of such supramolecular disassembly principles could have broad implications in a variety of biological applications.

  DOI：

  10.1021/ja4108676

文献信息

• Protein AND Enzyme Gated Supramolecular Disassembly
  作者：Jing Guo、Jiaming Zhuang、Feng Wang、Krishna R. Raghupathi、S. Thayumanavan

  DOI：10.1021/ja4108676

  日期：2014.2.12

  An amphiphilic nanoassembly was designed to respond to the concurrent presence of a protein and an enzyme. We present herein a system, where in the presence of these two stimuli supramolecular disassembly and molecular release occur. This molecular release arises in the form a fluorescence response that has been shown to be specific. We also show that this system can be modified to respond only if light stimulus is also present in addition to the protein and the enzyme. Demonstration of such supramolecular disassembly principles could have broad implications in a variety of biological applications.