N-ethyl-D-alanine | 915405-03-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-ethyl-D-alanine
• 英文别名: (2R)-2-(ethylamino)propanoic acid
• CAS: 915405-03-7
• 化学式: C₅H₁₁NO₂
• 分子量: 117.148
• InChiKey: DATPFTPVGIHCCM-SCSAIBSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-carbobenzoyloxy-N-ethyl-D-alanine 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 、 水 为溶剂， 反应 20.0h， 生成 N-ethyl-D-alanine
  参考文献：
  名称：

  Synthesis of N-alkyl-N-methyl amino acids. Scope and limitations of base-induced N-alkylation of Cbz-amino acids

  摘要：

  The reaction of N-benzyloxycarbonyl derivatives of aliphatic amino acids with NaH/alkyl iodides gave the corresponding N-Cbz-N-alkyl derivatives in good to high yields. The scope and limitations of this simple N-alkylation reaction were investigated as a convenient and flexible attempt to prepare unsymmetrically N,N-diprotected alpha-amino acids. The procedure is based on the N-alkylation of N-carbamoyl amino acids, a one-pot deprotection/protection sequence without extensive purification of the products. Protection of the carboxyl function is not required while the starting materials are inexpensive and commercially available. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.03.025

文献信息

• 一种氨基酸及其衍生物的制备与纯化方法
  申请人：安徽普利药业有限公司

  公开号：CN115466189A

  公开（公告）日：2022-12-13

  本发明涉及医药化工领域，主要涉及一种氨基酸及其衍生物的制备与纯化方法，所述制备方法按照如下反应式进行， 本发明技术方案可以有效减少杂质的生成，得到高纯度、高收率的氨基酸及其衍生物。且纯化方法简便易操作，适用于工业化生产。
• Synthesis of N-alkyl-N-methyl amino acids. Scope and limitations of base-induced N-alkylation of Cbz-amino acids
  作者：Maciej Stodulski、Jacek Mlynarski

  DOI：10.1016/j.tetasy.2008.03.025

  日期：2008.5

  The reaction of N-benzyloxycarbonyl derivatives of aliphatic amino acids with NaH/alkyl iodides gave the corresponding N-Cbz-N-alkyl derivatives in good to high yields. The scope and limitations of this simple N-alkylation reaction were investigated as a convenient and flexible attempt to prepare unsymmetrically N,N-diprotected alpha-amino acids. The procedure is based on the N-alkylation of N-carbamoyl amino acids, a one-pot deprotection/protection sequence without extensive purification of the products. Protection of the carboxyl function is not required while the starting materials are inexpensive and commercially available. (C) 2008 Elsevier Ltd. All rights reserved.