3-[5-(2-nitrophenyl)-2-furyl]acrylic acid | 765937-82-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[5-(2-nitrophenyl)-2-furyl]acrylic acid
• 英文别名: 3-(5-(2-Nitrophenyl)furan-2-yl)acrylic acid；(E)-3-[5-(2-nitrophenyl)furan-2-yl]prop-2-enoic acid
• CAS: 765937-82-4
• 化学式: C₁₃H₉NO₅
• mdl: MFCD00551680
• 分子量: 259.218
• InChiKey: AOSUZFHFKHDFMW-SOFGYWHQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  96.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-[5-(2-nitrophenyl)-2-furyl]acrylic acid 在 氯化亚砜 作用下， 以 甲苯 为溶剂， 反应 4.0h， 生成 (E)-N-[3-benzoyl-4-[[2-(4-methylphenyl)acetyl]amino]phenyl]-3-[5-(2-nitrophenyl)furan-2-yl]prop-2-enamide
  参考文献：
  名称：

  非硫醇法呢基转移酶抑制剂：N-（4-甲苯基乙酰氨基-3-苯甲酰基苯基）-3-芳基呋喃基丙烯酸酰胺。

  摘要：

  我们已经设计了芳基呋喃基丙烯酸取代的二苯甲酮作为非硫醇法呢基转移酶抑制剂，利用了法呢基转移酶的新型芳基结合位点。这些化合物在低纳摩尔范围内显示活性。

  DOI：

  10.1016/j.bmc.2004.07.010
• 作为产物：
  描述：

  2-硝基苯基硼酸 在 哌啶 、 吡啶 、 四(三苯基膦)钯 、 potassium carbonate 作用下， 以 乙醇 、 甲苯 为溶剂， 反应 7.0h， 生成 3-[5-(2-nitrophenyl)-2-furyl]acrylic acid
  参考文献：
  名称：

  Structure–Activity relationships of novel anti-Malarial agents. Part 4: N-(3-Benzoyl-4-tolylacetylaminophenyl)-3-(5-aryl-2-furyl)acrylic acid amides

  摘要：

  In a previous report, we have described novel anti-malarial compounds based on a 2,5-diaminobenzophenone scaffold. Here, we have invesigated acryloyl derivatives carrying a biaryl structure consisting of a terminal aryl residue and a central 2-furyl ring. Several compounds were obtained in the series of para-substituted phenylfurylacryloyl derivatives that displayed improved anti-malarial activity in comparison to earlier described derivatives. From the structure-activity relationships it can be deduced that there has to be a lipophilic moiety in the para-position of the terminal phenyl residue. Furthermore, there are indications that, alternatively, activity may benefit from the presence of a polar moiety with hydrogen bond acceptor properties. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00555-3

文献信息

• KRADOVICOVA E.; KRUTOSIKOVA A.; KOVAC J., COLLECT. CZECHOSL. CHEM. COMMUN., 51,(1986) N 8, 1685-1691
  作者：KRADOVICOVA E.、 KRUTOSIKOVA A.、 KOVAC J.

  DOI：——

  日期：——
• KRALOVICOVA, EVA;KRUTOSIKOVA, ALZBETA;KOVAC, JAROSLAV
  作者：KRALOVICOVA, EVA、KRUTOSIKOVA, ALZBETA、KOVAC, JAROSLAV

  DOI：——

  日期：——
• UV curable resin, its preparation and composition containing the same
  申请人：Hwang Kuen-Yuan

  公开号：US20080275153A1

  公开（公告）日：2008-11-06

  The present invention relates to an ultraviolet curable resin of the present invention which is prepared from alkyl(meth)acrylates, glycidyl(meth)acrylate, and substituted or unsubstituted acrylic acid, wherein the resin contains terminal vinyl group in amount of at least 50 wt % based on the resin and its glass transition temperature (Tg) is in a range of from 40˜100° C. The present invention also relates to a resin composition containing the ultraviolet curable resin.
• Non-thiol farnesyltransferase inhibitors: N-(4-tolylacetylamino-3-benzoylphenyl)-3-arylfurylacrylic acid amides
  作者：Andreas Mitsch、Pia Wißner、Katrin Silber、Peter Haebel、Isabel Sattler、Gerhard Klebe、Martin Schlitzer

  DOI：10.1016/j.bmc.2004.07.010

  日期：2004.9

  We have designed arylfurylacryl-substituted benzophenones as non-thiol farnesyltransferase inhibitors utilizing a novel aryl binding site of farnesyltransferase. These compounds display activity in the low nanomolar range.

  我们已经设计了芳基呋喃基丙烯酸取代的二苯甲酮作为非硫醇法呢基转移酶抑制剂，利用了法呢基转移酶的新型芳基结合位点。这些化合物在低纳摩尔范围内显示活性。
• Structure–Activity relationships of novel anti-Malarial agents. Part 4: N-(3-Benzoyl-4-tolylacetylaminophenyl)-3-(5-aryl-2-furyl)acrylic acid amides
  作者：Jochen Wiesner、Andreas Mitsch、Pia Wißner、Oliver Krämer、Hassan Jomaa、Martin Schlitzer

  DOI：10.1016/s0960-894x(02)00555-3

  日期：2002.10

  In a previous report, we have described novel anti-malarial compounds based on a 2,5-diaminobenzophenone scaffold. Here, we have invesigated acryloyl derivatives carrying a biaryl structure consisting of a terminal aryl residue and a central 2-furyl ring. Several compounds were obtained in the series of para-substituted phenylfurylacryloyl derivatives that displayed improved anti-malarial activity in comparison to earlier described derivatives. From the structure-activity relationships it can be deduced that there has to be a lipophilic moiety in the para-position of the terminal phenyl residue. Furthermore, there are indications that, alternatively, activity may benefit from the presence of a polar moiety with hydrogen bond acceptor properties. (C) 2002 Elsevier Science Ltd. All rights reserved.