2-((2-((6-acetylnaphthalen-2-yl)(methyl)amino)ethyl)(2-mercaptoethyl)amino)-N-(2-mercaptoethyl)acetamide | 1276041-68-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-((2-((6-acetylnaphthalen-2-yl)(methyl)amino)ethyl)(2-mercaptoethyl)amino)-N-(2-mercaptoethyl)acetamide
• 英文别名: 2-[2-[(6-acetylnaphthalen-2-yl)-methylamino]ethyl-(2-sulfanylethyl)amino]-N-(2-sulfanylethyl)acetamide
• CAS: 1276041-68-9
• 化学式: C₂₁H₂₉N₃O₂S₂
• 分子量: 419.612
• InChiKey: SRQBUVPKQHWREK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  28
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  54.6
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  6-乙酰基-2-萘酚 在 potassium disulphite 、 N-溴代丁二酰亚胺(NBS) 、 甲烷磺酸 、 苯甲醚 、 N,N-二异丙基乙胺 、 三苯基膦 、 三氟乙酸 作用下， 以 二氯甲烷 、 水 、 乙腈 为溶剂， 反应 87.67h， 生成 2-((2-((6-acetylnaphthalen-2-yl)(methyl)amino)ethyl)(2-mercaptoethyl)amino)-N-(2-mercaptoethyl)acetamide
  参考文献：
  名称：

  99mTc- and Re-labeled 6-dialkylamino-2-naphthylethylidene derivatives as imaging probes for β-amyloid plaques

  摘要：

  Based on the conjugate strategy, two neutral Tc-99m labeled 2-(1-(6-(dialkylamino)naphthalen-2-yl) ethylidene) malononitrile (DDNP) and 1-(6-(dialkylamino) naphthalen-2-yl) ethanone (ENE) derivatives, and their corresponding rhenium complexes were synthesized. In vitro fluorescent staining indicated that the corresponding rhenium derivatives selectively stained the beta-amyloid (A beta) plaques in the brain sections of AD model mice with low background. Compared with FDDNP and FENE, the affinities of the corresponding rhenium derivatives to A beta aggregates decreased about 10-14-fold. In vivo biodistribution experiments in normal mice showed that Tc-99m-MAMA-ENE displayed medium initial brain uptake (0.65 % ID/g at 2 min) with a reasonable washout from the brain (0.19 % ID/g at 2 h) while (99mTc)-MAMA-DDNP showed a low brain uptake (0.28 % ID/g at 2 min). Further optimize these Tc-99m-labeled tracers in order to improve their binding affinities to A beta plaques and diffusion through the blood brain barrier may generate useful imaging agents for SPECT. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.11.096

文献信息

• 99mTc- and Re-labeled 6-dialkylamino-2-naphthylethylidene derivatives as imaging probes for β-amyloid plaques
  作者：Mengchao Cui、Ruikun Tang、Zijing Li、Huiying Ren、Boli Liu

  DOI：10.1016/j.bmcl.2010.11.096

  日期：2011.2

  Based on the conjugate strategy, two neutral Tc-99m labeled 2-(1-(6-(dialkylamino)naphthalen-2-yl) ethylidene) malononitrile (DDNP) and 1-(6-(dialkylamino) naphthalen-2-yl) ethanone (ENE) derivatives, and their corresponding rhenium complexes were synthesized. In vitro fluorescent staining indicated that the corresponding rhenium derivatives selectively stained the beta-amyloid (A beta) plaques in the brain sections of AD model mice with low background. Compared with FDDNP and FENE, the affinities of the corresponding rhenium derivatives to A beta aggregates decreased about 10-14-fold. In vivo biodistribution experiments in normal mice showed that Tc-99m-MAMA-ENE displayed medium initial brain uptake (0.65 % ID/g at 2 min) with a reasonable washout from the brain (0.19 % ID/g at 2 h) while (99mTc)-MAMA-DDNP showed a low brain uptake (0.28 % ID/g at 2 min). Further optimize these Tc-99m-labeled tracers in order to improve their binding affinities to A beta plaques and diffusion through the blood brain barrier may generate useful imaging agents for SPECT. (C) 2010 Elsevier Ltd. All rights reserved.