1,3-Bis(hydroxysulfanyl)benzene | 943302-90-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,3-Bis(hydroxysulfanyl)benzene
• 英文别名: 1,3-bis(hydroxysulfanyl)benzene
• CAS: 943302-90-7
• 化学式: C₆H₆O₂S₂
• 分子量: 174.244
• InChiKey: PTWDEKUVTYYBHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  91.1
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,3-Bis(hydroxysulfanyl)benzene 、 2-炔丙基-四-O-乙酰基-β-D-吡喃葡萄糖苷 生成 [(2R,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-[2-[3-[3-[(2R,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxyprop-1-en-2-ylsulfinyl]phenyl]sulfinylprop-2-enoxy]oxan-2-yl]methyl acetate
  参考文献：
  名称：

  Sulfenic acid – derived glycoconjugated disulfides and sulfoxides: a biological evaluation on human red blood cells

  摘要：

  This article examines the effects of some glycoconjugated disulfides and sulfoxides on red blood cells (RBCs). Compounds under study show sugar units connected directly or through a benzene platform, and have been obtained following synthetic pathways based on the sulfenic acid chemistry. In order to evaluate the relationship between the structural features of the thioglycoconjugates under investigation and their potential biological activity, we were interested in assessing both the cytotoxicity and hemolytic activity produced on human RBCs by overnight exposition to the thioglycoconjugates. The absence of both cytotoxic effect and hemolysis produced by the tested compounds on erythrocytes supports the rational design of hemocompatible molecules for biomedical applications.[GRAPHICS].

  DOI：

  10.1080/17415993.2013.778259
• 作为产物：
  描述：

  3,3'-[1,3-phenylenebis(sulfinyl)]bispropanoic acid 1,1'-dimethyl ester 生成 1,3-Bis(hydroxysulfanyl)benzene
  参考文献：
  名称：

  Sulfenic acid – derived glycoconjugated disulfides and sulfoxides: a biological evaluation on human red blood cells

  摘要：

  This article examines the effects of some glycoconjugated disulfides and sulfoxides on red blood cells (RBCs). Compounds under study show sugar units connected directly or through a benzene platform, and have been obtained following synthetic pathways based on the sulfenic acid chemistry. In order to evaluate the relationship between the structural features of the thioglycoconjugates under investigation and their potential biological activity, we were interested in assessing both the cytotoxicity and hemolytic activity produced on human RBCs by overnight exposition to the thioglycoconjugates. The absence of both cytotoxic effect and hemolysis produced by the tested compounds on erythrocytes supports the rational design of hemocompatible molecules for biomedical applications.[GRAPHICS].

  DOI：

  10.1080/17415993.2013.778259

文献信息

• Sulfenic acid – derived glycoconjugated disulfides and sulfoxides: a biological evaluation on human red blood cells
  作者：Paola Bonaccorsi、Maria Chiara Aversa、Anna Barattucci、Teresa Papalia、Agata Torre、Francesca Trischitta、Caterina Faggio

  DOI：10.1080/17415993.2013.778259

  日期：2013.12.1

  This article examines the effects of some glycoconjugated disulfides and sulfoxides on red blood cells (RBCs). Compounds under study show sugar units connected directly or through a benzene platform, and have been obtained following synthetic pathways based on the sulfenic acid chemistry. In order to evaluate the relationship between the structural features of the thioglycoconjugates under investigation and their potential biological activity, we were interested in assessing both the cytotoxicity and hemolytic activity produced on human RBCs by overnight exposition to the thioglycoconjugates. The absence of both cytotoxic effect and hemolysis produced by the tested compounds on erythrocytes supports the rational design of hemocompatible molecules for biomedical applications.[GRAPHICS].