N-(2-hydroxy-1-hydroxymethyl-1-methyl-ethyl)-benzenesulfonamide | 204982-64-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-hydroxy-1-hydroxymethyl-1-methyl-ethyl)-benzenesulfonamide
• 英文别名: N-(β.β'-Dihydroxy-tert-butyl)-benzolsulfonamid；N-(2-Hydroxy-1-hydroxymethyl-1-methyl-aethyl)-benzolsulfonamid；2-Benzolsulfonylamino-2-methyl-propandiol-(1.3)；N-(1,3-dihydroxy-2-methylpropan-2-yl)benzenesulfonamide
• CAS: 204982-64-9
• 化学式: C₁₀H₁₅NO₄S
• 分子量: 245.299
• InChiKey: FXFLFZLWSZEBBU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  95
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  苯磺酰氯 、 2-氨基-2-甲基-1,3-丙二醇 在 sodium carbonate 、 丙酮 作用下， 生成 N-(2-hydroxy-1-hydroxymethyl-1-methyl-ethyl)-benzenesulfonamide
  参考文献：
  名称：

  Shupe, Journal of the Association of Official Agricultural Chemists, 1942, vol. 25, p. 228

  摘要：

  DOI：

文献信息

• Plasticized polymer compositions
  申请人：UCB, S.A.

  公开号：US20020165301A1

  公开（公告）日：2002-11-07

  The invention relates to compositions comprising at least one polymer and at least one plasticizer, in which compositions the polymer is semi-crystalline and exhibits a processing temperature equal to or greater than 220° C., preferably 250° C., and the plasticizer is an aromatic benzenesulphonamide represented by the general formula (I) 1 in which R 1 represents a hydrogen atom, a C 1 -C 4 alkyl group or a C 1 -C 4 alkoxy group, X represents a linear or branched C 2 -C 10 alkylene group, or a cycloaliphatic group, or an aromatic group, Y represents one of the groups OH or 2 R 2 representing a C 1 -C 4 alkyl group or an aromatic group, these groups optionally themselves being substituted by an OH or C 1 -C 4 alkyl group. The aromatic benzenesulphonamides have little volatility and exhibit good thermal stability, which makes it possible to effectively plasticize polyamides which are processed at high temperatures, such as polyamides-6, -6,6, -4,6, -6,9, -6,10, -6,12 and MDX-6 and polyketones, but also polyamides-11 and -12, polyoxymethylene and poly(vinylidene fluoride).

  本发明涉及一种包含至少一种聚合物和至少一种增塑剂的组合物，其中聚合物是半结晶的，处理温度等于或大于220℃，优选为250℃，增塑剂是一种芳香基苯磺酰胺，其通式为（I）： 其中，R1代表氢原子、C1-C4烷基或C1-C4烷氧基；X代表线性或支链状的C2-C10烷基、环状脂肪族基、芳香族基；Y代表OH基或2个R2代表C1-C4烷基或芳香族基，这些基团可以自身被OH基或C1-C4烷基所取代。 这些芳香基苯磺酰胺的挥发性很小，具有良好的热稳定性，可以有效地增塑高温加工的聚酰胺，如聚酰胺-6、-6,6、-4,6、-6,9、-6,10、-6,12和MDX-6以及聚酮，还可以增塑聚酰胺-11和-12、聚甲醛和聚偏氟乙烯。
• COMPOSITIONS DE POLYMERES PLASTIFIES
  申请人：UCB, S.A.

  公开号：EP0929603A1

  公开（公告）日：1999-07-21
• PLASTICIZED POLYOXYMETHYLENE
  申请人：Ticona GmbH

  公开号：EP2652038A1

  公开（公告）日：2013-10-23
• POLYOXYMETHYLENE POLYMER COMPOSITION THAT IS CHEMICAL RESISTANT
  申请人：Ticona LLC

  公开号：EP3618683A1

  公开（公告）日：2020-03-11
• SCREENING METHODS FOR AMYLOID BETA MODULATORS
  申请人：Slon-Usakiewicz Jacek

  公开号：US20110028719A1

  公开（公告）日：2011-02-03

  The present invention relates to methods for screening, identifying, and/or quantifying modulators of amyloid and/or aggregates, fibrils or components thereof, in particular modulators of amyloid β-peptide (Aβ) or Aβ fibrils. Aspects of the invention provide methods for screening putative modulators against an Amyloid target, in particular an Aβ target, so as to determine which modulators bind to or interact with the target, or interfere with the interaction of an indicator agent and the target. Particular aspects of the invention employ mass spectrometric methods for the screening of an Amyloid target against compound libraries, in particular mixtures of compounds or combinatorial libraries.