10-(4-hydroxy-phenyl)-decanoic acid | 53306-49-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 10-(4-hydroxy-phenyl)-decanoic acid
• 英文别名: 10-(4-Hydroxy-phenyl)-decansaeure；10-(p-Hydroxyphenyl)decansaeure；10-(4-Hydroxyphenyl)decanoic acid
• CAS: 53306-49-3
• 化学式: C₁₆H₂₄O₃
• 分子量: 264.365
• InChiKey: OHPPRDXYSOBVMB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  19
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  10-(4-hydroxy-phenyl)-decanoic acid 在 Pd/SrCO₃ 、 硫酸 、 乙酸乙酯 、 苯 作用下， 生成 10-(4-hydroxy-cyclohexyl)-decanoic acid
  参考文献：
  名称：

  Naphthoquinone Antimalarials. XXV.¹ Naphthoquinones with Oxygen in the Side Chain

  摘要：

  DOI：

  10.1021/ja01167a070
• 作为产物：
  描述：

  10-(4-methoxy-phenyl)-10-oxo-decanoic acid 在 氢溴酸 、 sodium 、 乙二醇 、 溶剂黄146 、 肼 作用下， 生成 10-(4-hydroxy-phenyl)-decanoic acid
  参考文献：
  名称：

  Left ventricular diastolic function abnormalities in hypopituitary patients with GH deficiency: Evidence for a subclinical cardiomyopathy

  摘要：

  The aim of this study was to evaluate cardiac performance, in particular diastolic function, in adult patients with adulthood onset GH deficiency. The study group was composed of 19 GH deficient adult hypopituitary patients with at-least 3 additional pituitary hormone deficits and 19 age, sex and BMI matched healthy controls. Mean duration of hypopituitarism was 108.6 +/- 77.0 months. None of the patients and controls presented with or had previous diagnosis of concomitant diseases that could affect cardiac function. All hormone deficiencies, except for GH, were appropriately replaced in the patients. Left ventricular function and geometry were evaluated by two-dimensional, M-mode and Doppler echocardiography. Body composition was evaluated by bioelectrical impedance analysis. Not significant differences were observed with respect to left heart dimensions and left ventricular systolic function between patients and controls. Nevertheless 2 of the left ventricular diastolic function parameters, deceleration time and isovolumetric relaxation time, were significantly prolonged in the patients compared with controls (247.88 +/- 70.65 vs 143.26 +/- 31.70 milliseconds (ms) and 122.31 +/- 18.24 vs 89.47 +/- 12.12 ms respectively, p<0.001). Duration of hypopituitarism was significantly correlated with percent body fat mass (r=0.6119, p<0.01) and percent lean body mass (r=-0.5949, p<0.01). It is concluded that in adults affected by hypopituitarism, GH deficiency predominantly impairs diastolic function while systolic function at rest is spared. This observation might indicate a preclinical stage of a cardiomyopathy.

  DOI：

  10.1007/bf03345081

文献信息

• X-Ray Diagnostics. II. Cholecystographic Agents¹
  作者：Domenick Papa、Erwin Schwenk、Hilda Breiger、Virginia Peterson

  DOI：10.1021/ja01162a077

  日期：1950.6
• Organic acids
  申请人：JEWISH HOSPITAL

  公开号：US02400433A1

  公开（公告）日：1946-05-14
• Left ventricular diastolic function abnormalities in hypopituitary patients with GH deficiency: Evidence for a subclinical cardiomyopathy
  作者：N. Özbey、A. Sezgil、H. Oflaz、B. Umman、Y. Orhan、E. Sencer、S. Molvalilar

  DOI：10.1007/bf03345081

  日期：2002.7

  The aim of this study was to evaluate cardiac performance, in particular diastolic function, in adult patients with adulthood onset GH deficiency. The study group was composed of 19 GH deficient adult hypopituitary patients with at-least 3 additional pituitary hormone deficits and 19 age, sex and BMI matched healthy controls. Mean duration of hypopituitarism was 108.6 +/- 77.0 months. None of the patients and controls presented with or had previous diagnosis of concomitant diseases that could affect cardiac function. All hormone deficiencies, except for GH, were appropriately replaced in the patients. Left ventricular function and geometry were evaluated by two-dimensional, M-mode and Doppler echocardiography. Body composition was evaluated by bioelectrical impedance analysis. Not significant differences were observed with respect to left heart dimensions and left ventricular systolic function between patients and controls. Nevertheless 2 of the left ventricular diastolic function parameters, deceleration time and isovolumetric relaxation time, were significantly prolonged in the patients compared with controls (247.88 +/- 70.65 vs 143.26 +/- 31.70 milliseconds (ms) and 122.31 +/- 18.24 vs 89.47 +/- 12.12 ms respectively, p<0.001). Duration of hypopituitarism was significantly correlated with percent body fat mass (r=0.6119, p<0.01) and percent lean body mass (r=-0.5949, p<0.01). It is concluded that in adults affected by hypopituitarism, GH deficiency predominantly impairs diastolic function while systolic function at rest is spared. This observation might indicate a preclinical stage of a cardiomyopathy.
• Naphthoquinone Antimalarials. XXV.¹ Naphthoquinones with Oxygen in the Side Chain
  作者：Marvin Paulshock、Carl M. Moser

  DOI：10.1021/ja01167a070

  日期：1950.11