3,4-二氢吡喃甲酰胺 | 49831-28-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 中文名称: 3,4-二氢吡喃甲酰胺
• 中文别名: 3,4-二氢-2H-吡喃-2-羧酰胺
• 英文名称: 3,4-dihydro-2H-pyran-2-carboxamide
• 英文别名: 3,4-dihydro-2H-pyran-2-carboxylic acid amide；3,4-Dihydro-2H-pyran-2-carbonsaeure-amid；(+/-)-3,4-Dihydro-2H-pyran-carbonsaeure-(2)-amid；3,4-Dihydro-2H-pyran-carbonsaeure-(2)-amid；2-Carbamoyl-2,3-dihydro-4H-pyran
• CAS: 49831-28-9
• 化学式: C₆H₉NO₂
• mdl: MFCD08062364
• 分子量: 127.143
• InChiKey: ARLWMQMHHIPRCO-UHFFFAOYSA-N

物化性质

• 熔点：
  112.5 °C
• 沸点：
  328.6±42.0 °C(Predicted)
• 密度：
  1.164±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3,4-二氢吡喃甲酰胺 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 生成 3,4-二氢吡喃甲胺
  参考文献：
  名称：

  的合成顺式-和反-2（小号）-phthalimido甲基甲基-2,3,4,4a，7,7A六氢-6-氧代-5- ħ吡喃并[2,3- b ]吡咯作为刚性β-弯曲肽模拟物†

  摘要：

  所述的合成顺式- 14和抗- 13分2（异构体小号）-phthalimidornethyl甲基-2,3,4,4a，7,7A六氢-6-氧代-5- ħ吡喃并[2,3- b ]吡咯从3，4-二氢-2 H-吡喃-2-羧酸钠开始完成。通过制备型高效液相色谱分离异构体。两种异构体都可以充当β-弯曲模拟物，代表三个氨基酸加一个肽的第四个氨基酸的氨基。将内酰胺氮烷基化以提供相当于第四氨基酸残基的亮氨酸。

  DOI：

  10.1002/jhet.5570290406
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 ammonium hydroxide 作用下， 生成 3,4-二氢吡喃甲酰胺
  参考文献：
  名称：

  Reactions of Acrolein and Related Compounds. I. Addition of Vinyl Ethers

  摘要：

  DOI：

  10.1021/ja01155a076

文献信息

• Dihydropyrancarboxamides and uses thereof
  申请人：——

  公开号：US20040059138A1

  公开（公告）日：2004-03-25

  The present invention provides novel dihydropyrancarboxamide compounds of formula (I): 1 and collections of these compounds, and provides methods for the synthesis of these compounds; wherein R 1 -R 6 are as defined herein. Additionally, the present invention provides pharmaceutical compositions and methods for treating disorders such as proliferative diseases, and cancer, to name a few.

  本发明提供了式（I）的新颖二氢吡喃羧酰胺化合物： 1 以及这些化合物的集合，并提供了合成这些化合物的方法；其中R 1 -R 6 如本文所定义。此外，本发明提供了用于治疗增殖性疾病和癌症等疾病的药物组合物和方法。
• 5H-6-oxo-2,3,4,4a,7,7a-hexahydropyrano[2,3-b]pyrrole and the preparation
  申请人：The Board of Trustees of the University of Illinois

  公开号：US04535169A1

  公开（公告）日：1985-08-13

  Conformationally restricted peptide analogs incorporating a rigid .beta.-bend are formed by replacing a portion of the peptide backbone chain with a bicyclic heterocycle, 5H-6-oxo-2,3,4,4a,7,7a-hexahydropyrano[2,3-b]pyrrole. Properly substituted derivatives of the pyranopyrrole are conformationally rigid and cannot assume non-.beta.-bend conformations in the interior of the peptide chain, while the terminal binding residues are maintained in the proper orientation for receptor interaction. Also described are a novel intermediate for preparation of the peptide analogs and a method for preparation of the intermediate.

  通过用双环杂环物5H-6-氧代-2,3,4,4a,7,7a-六氢吡喃并[2,3-b]吡咯替换多肽骨架链的一部分，形成了构象受限的多肽类似物，其中包含一个刚性的β-弯曲。正确取代的吡喃吡咯衍生物在构象上是刚性的，不能在多肽链的内部采取非β-弯曲构象，同时终端结合残基保持正确的取向以进行受体相互作用。还描述了制备多肽类似物的新型中间体和制备中间体的方法。
• SYNTHESIS OF BROMO-SUBSTITUTED BICYCLIC OXALACTAM AND UNUSUAL ANIONIC DESALTING OLIGOMERIZATION OF ITS SODIUM SALT
  作者：Kazuhiko Hashimoto、Hiroshi Sumitomo、Masanori Suzuki

  DOI：10.1246/cl.1986.767

  日期：1986.5.5

  New bromo-substituted bicyclic oxalactam, 4(e)-bromo-8-oxa-6-azabicyclo[3.2.1]octan-7-one (1) was synthesized from sodium 3,4-dihydro-2H-pyran-2-carboxylate. Sodium salt of 1 was found to be oligomerized with the simultaneous desalting in dimethylformamide at 25 °C to give novel oligomers having a bicyclic oxalactam ring in each monomer unit.

  新的溴取代双环草内酰胺，4(e)-bromo-8-oxa-6-azabicyclo[3.2.1]octan-7-one (1) 由 3,4-dihydro-2H-pyran-2- 钠合成羧酸盐。发现 1 的钠盐在 25°C 下在二甲基甲酰胺中脱盐的同时发生低聚，得到在每个单体单元中具有双环草内酰胺环的新型低聚物。
• Reagents and methods for library synthesis and screening
  申请人：Howard Hughes Medical Institute

  公开号：US20040014168A1

  公开（公告）日：2004-01-22

  The invention provides novel solid supports for the synthesis of compound libraries. The solid supports have the physical capacity to deliver at least 50 nmol of compound and are functionalized with a silicon-containing linker. In one embodiment of the invention the solid support comprises a bead having a diameter of between approximately 400 and 600 &mgr;m functionalized with a silicon-containing linker. According to certain embodiments of the invention the bead is a polystyrene bead. According to certain embodiments of the invention the linker is a diisopropylalkyl-substituted silyl ether. The invention further provides grafted polymeric supports such as lanterns functionalized with a silicon-containing linker. The invention provides methods for screening in which compounds are synthesized on solid supports in a quantity so that a single solid support such as a bead provides a stock solution sufficient to perform hundreds or thousands of biological or chemical assays. The methods include decoding the sequence of chemical reactions used to synthesize the compound by identifying tags incorporated into the compound during synthesis.

  本发明提供了用于合成化合物库的新型固体支持体。这些固体支持体具有物理容量，能够提供至少50纳摩尔的化合物，并且具有含硅连接剂的功能化。在本发明的一个实施例中，固体支持体包括一个直径在大约400到600微米之间的珠子，功能化了含硅连接剂。根据本发明的某些实施例，珠子是聚苯乙烯珠子。根据本发明的某些实施例，连接剂是二异丙基烷基取代的硅醚。本发明还提供了用含硅连接剂的嫁接聚合物支持体，例如用于筛选的灯笼。本发明提供了一种筛选方法，其中化合物在固体支持体上合成，以便单个固体支持体（如珠子）提供足够执行数百或数千个生物或化学分析的储备溶液。该方法包括通过识别在合成过程中合并到化合物中的标签来解码用于合成化合物的化学反应序列。
• Methods and Compositions for Weed Control
  申请人：MONSANTO TECHNOLOGY LLC

  公开号：US20160029644A1

  公开（公告）日：2016-02-04

  The present invention provides novel compositions for use to enhance weed control. Specifically, the present invention provides for methods and compositions that modulate gene expression in johnsongrass. The present invention also provides for combinations of compositions and methods that enhance johnsongrass control. The invention comprises a method of Sorghum species weed control, in particular johnsongrass ( Sorghum halepense ) plant control comprising an external application of a herbicidal composition to a Sorghum halepense plant or a part of the Sorghum halepense plant in need of control, said herbicidal composition comprising a polynucleotide, an organosilicone surfactant concentration of about 0.2 percent or greater, and an effective dose of a nonpolynucleotide herbicide.

  本发明提供了新型组合物，用于增强除草的效果。具体而言，本发明提供了一种调节粟草基因表达的方法和组合物。本发明还提供了一种增强粟草控制的方法和组合物的组合。该发明涉及一种粟属植物除草的方法，特别是粟属植物粟草（Sorghum halepense）的植株控制方法，包括对需要控制的Sorghum halepense植株或其部分进行除草剂组合物的外部应用，所述除草剂组合物包括多核苷酸、有机硅表面活性剂浓度为0.2％或更高和有效剂量的非多核苷酸除草剂。