2-(9H-fluoren-9-yl)acetaldehyde | 142532-75-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 2-(9H-fluoren-9-yl)acetaldehyde
• 英文别名: 9'-Fluorenylacetaldehyd
• CAS: 142532-75-0
• 化学式: C₁₅H₁₂O
• 分子量: 208.26
• InChiKey: LRMKIHQXIRRHDU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(9H-fluoren-9-yl)acetaldehyde 、 在 三乙酰氧基硼氢化钠 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 16.0h， 生成 3-[2-(9H-fluoren-9-yl)ethyl-propan-2-ylamino]-1-[4-(4-nitrophenyl)piperazin-1-yl]propan-1-one
  参考文献：
  名称：

  Discovery of novel non-peptidic β-alanine piperazine amide derivatives and their optimization to achiral, easily accessible, potent and selective somatostatin sst1 receptor antagonists

  摘要：

  Structural simplification of the core moieties of obeline and ergoline somatostatin sst(1) receptor antagonists, followed by systematic optimization, led to the identification of novel, highly potent and selective sst(1) receptor antagonists. These achiral, non-peptidic compounds are easily prepared and show promising PK properties in rodents. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.01.072
• 作为产物：
  描述：

  2-氨基联苯 在 盐酸 、 四(三苯基膦)钯 、 sodium formate 、 三乙胺 、 间氯过氧苯甲酸 、 sodium nitrite 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 、 1,2-二氯乙烷 为溶剂， 反应 17.0h， 生成 2-(9H-fluoren-9-yl)acetaldehyde
  参考文献：
  名称：

  模块化串联Mizoroki-Heck /还原性Heck反应从环状二芳基碘鎓盐构建芴

  摘要：

  从环状二芳基碘鎓和末端烯烃开始，可以方便地构建各种芴。钯催化的反应会进行一种常规的Mizoroki-Heck反应和一种还原性Heck反应。烯烃的范围很广，导致有29个芴，这将扩大芴储层的结构多样性。

  DOI：

  10.1002/adsc.202001080

文献信息

• SEVEN-MEMBERED RING COMPOUND AND PHARMACEUTICAL USE THEREFOR
  申请人：Muto Tsuyoshi

  公开号：US20120259111A1

  公开（公告）日：2012-10-11

  A compound having a 7-membered nitrogen-containing ring skeleton represented by the formula (I), which is useful for the prevention or treatment of diseases, in which chymase is involved and a pharmaceutical containing the same for the prevention or treatment of a disease, in which chymase is involved.

  一种具有由式(I)表示的含氮七元环骨架的化合物，对涉及chymase的疾病的预防或治疗有用，以及含有该化合物的药物，用于预防或治疗涉及chymase的疾病。
• 4-(1-AMINO-ETHYL)-CYCLOHEXYLAMINE DERIVATIVES
  申请人：Hubschwerlen Christian

  公开号：US20100029623A1

  公开（公告）日：2010-02-04

  The invention relates to compounds of formula (I) wherein R 0 represents H or OH; R 1 represents alkoxy; U and W represent N, V represents CH and R 2 represents H or F, or U and V represent CH, W represents N and R 2 represents H or F, or U and V represent N, W represents CH and R 2 represents H, or U represents N. V represents CH, W represents CR a and R 2 represents H; R a represents CH 2 OH or alkoxycarbonyl; A represents the group CH═CH—B or a binuclear heterocyclic system D, B representing a mono- or di-substituted phenyl group wherein the substituents are halogen atoms and D representing one of the following groups wherein Z represents CH or N, and Q represents O or S; and to salts of such compounds. These compounds are useful as antibacterial agents.

  该发明涉及以下式（I）的化合物，其中R 0 代表H或OH；R 1 代表烷氧基；U和W代表N，V代表CH，R 2 代表H或F，或者U和V代表CH，W代表N，R 2 代表H或F，或者U和V代表N，W代表CH，R 2 代表H，或者U代表N。V代表CH，W代表CR a ，R 2 代表H；R a 代表CH 2 OH或烷氧羰基；A代表基团CH═CH—B或双核杂环系统D，B代表一个单取代或双取代的苯基，其中取代基为卤原子，D代表以下其中之一的基团，其中Z代表CH或N，Q代表O或S；以及这些化合物的盐。这些化合物可用作抗菌剂。
• MOLECULES HAVING CERTAIN PESTICIDAL UTILITIES, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES RELATED THERETO
  申请人：Dow AgroSciences LLC

  公开号：US20160024026A1

  公开（公告）日：2016-01-28

  This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Nematoda, Arthropoda, and/or Mollusca, processes to produce such molecules and intermediates used in such processes, compositions containing such molecules, and processes of using such molecules against such pests. These molecules may be used, for example, as nematicides, acaricides, insecticides, miticides, and/or molluscicides. This document discloses molecules having the following formula (“Formula One”).

  这份披露涉及具有对线虫门、节肢动物门和/或软体动物门害虫有用的分子领域，用于生产这种分子和用于这种过程的中间体的过程，含有这种分子的组合物，以及使用这种分子对抗这些害虫的过程。这些分子可以用作线虫杀虫剂、螨虫杀虫剂、杀虫剂、螨虫剂和/或软体动物杀虫剂。本文件披露了具有以下式（“式一”）的分子。
• MOLECULES HAVING CERTAIN PESTICIDAL UTILITIES, INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO
  申请人：Dow AgroSciences LLC

  公开号：US20160021883A1

  公开（公告）日：2016-01-28

  This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Nematoda, Arthropoda, and/or Mollusca, processes to produce such molecules and intermediates used in such processes, compositions containing such molecules, and processes of using such molecules against such pests. These molecules may be used, for example, as nematicides, acaricides, insecticides, miticides, and/or molluscicides. This document discloses molecules having the following formula (“Formula One”).

  这份披露涉及具有对线虫门、节肢动物门和/或软体动物门害虫有用的分子领域，用于生产这种分子和用于这种过程的中间体的过程，含有这种分子的组合物，以及使用这种分子对抗这些害虫的过程。这些分子可以用作线虫杀虫剂、螨虫杀虫剂、杀虫剂、螨虫剂和/或软体动物杀虫剂。本文件披露了具有以下式（“式一”）的分子。
• [EN] SYNTHESIS OF DIVERSE GLYCOSYLPHOSPHATIDYLINOSITOL GLYCANS FROM TOXOPLASMA GONDII AND THEIR APPLICATION AS VACCINES AND DIAGNOSTICS<br/>[FR] SYNTHÈSE DE DIVERS GLYCOSYLPHOSPHATIDYLINOSITOL GLYCANES À PARTIR DE TOXOPLASMA GONDII ET LEUR APPLICATION EN TANT QUE VACCINS ET OUTILS DE DIAGNOSTIC
  申请人：MAX PLANCK GESELLSCHAFT

  公开号：WO2014016317A1

  公开（公告）日：2014-01-30

  The present invention relates to the synthesis of GPI-related surface antigens of the parasite Toxoplasma gondii (T. gondii) and the resulting products obtained. These synthetic compounds are suitable for diagnosis of toxoplasmosis, as well as vaccine against toxoplasmosis, a diseases caused by infection with T. gondii.

  本发明涉及寄生虫弓形虫（Toxoplasma gondii，T. gondii）的GPI相关表面抗原的合成以及所得到的产物。这些合成化合物适用于弓形虫病的诊断，以及针对由感染弓形虫引起的疾病弓形虫病的疫苗。