5,7-dimethyl-3-(2-oxo-2-phenylethylidene)indolin-2-one | 70452-33-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5,7-dimethyl-3-(2-oxo-2-phenylethylidene)indolin-2-one
• 英文别名: 3-Phenacyliden-5,7-dimethyl-2-indolinon；5,7-dimethyl-3-phenacylidene-1H-indol-2-one
• CAS: 70452-33-4
• 化学式: C₁₈H₁₅NO₂
• 分子量: 277.323
• InChiKey: ZEUQWGKSPURZFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5,7-dimethyl-3-(2-oxo-2-phenylethylidene)indolin-2-one 、 S-benzyldithiocarbazate 以 乙醇 为溶剂， 生成 5,7-dimethyl-1,3-dihydro-3-[2-(phenyl)-ethylidene]-2H-indol-2-one hydrazinecarbodithioic acid phenylmethyl ester
  参考文献：
  名称：

  Synthesis, Spectroscopic Characterization, and In Vitro Antimicrobial Potency of Sulfur-Bonded Complexes of Boron(III)

  摘要：

  The present article describes the synthesis and characterization of tetracoordinated boron (III) complexes with monobasic bidentate ligands ((LH)-H-1, (LH)-H-2, (LH)-H-3, (LH)-H-4, (LH)-H-5, and (LH)-H-6) having the general formulae PhB(L)(OH) and PhB(L)(2). The 1:1 and 1: 2 reactions of phenyl boronic acid with monobasic bidentate ligands resulted in the formation of colored solids. The complexes have been characterized by elemental analysis, molecular weight determinations, and IR and NMR (H-1, C-13 and B-11) spectroscopy, as well as UV-vis spectral studies. Based on these studies, a tetrahedral geometry has been proposed for the resulting complexes. The ligands, along with their complexes, have been screened in vitro against a number of pathogenic fungal and bacterial strains. The studies indicate that the boron chelates are more potent than the parent ligands.

  DOI：

  10.1080/10426500802445324
• 作为产物：
  描述：

  5,7-二甲基靛红 、 苯乙酮 以 乙醇 为溶剂， 生成 5,7-dimethyl-3-(2-oxo-2-phenylethylidene)indolin-2-one
  参考文献：
  名称：

  Synthesis, Spectroscopic Characterization, and In Vitro Antimicrobial Potency of Sulfur-Bonded Complexes of Boron(III)

  摘要：

  The present article describes the synthesis and characterization of tetracoordinated boron (III) complexes with monobasic bidentate ligands ((LH)-H-1, (LH)-H-2, (LH)-H-3, (LH)-H-4, (LH)-H-5, and (LH)-H-6) having the general formulae PhB(L)(OH) and PhB(L)(2). The 1:1 and 1: 2 reactions of phenyl boronic acid with monobasic bidentate ligands resulted in the formation of colored solids. The complexes have been characterized by elemental analysis, molecular weight determinations, and IR and NMR (H-1, C-13 and B-11) spectroscopy, as well as UV-vis spectral studies. Based on these studies, a tetrahedral geometry has been proposed for the resulting complexes. The ligands, along with their complexes, have been screened in vitro against a number of pathogenic fungal and bacterial strains. The studies indicate that the boron chelates are more potent than the parent ligands.

  DOI：

  10.1080/10426500802445324

文献信息

• Unexpected isocyanide-based cascade cycloaddition reaction with methyleneindolinone
  作者：Jian Li、Shikuan Su、Mengyuan Huang、Boyi Song、Chunju Li、Xueshun Jia

  DOI：10.1039/c3cc46237d

  日期：——

  An unprecedented cascade reaction of isocyanide and methyleneindolinone has been established, which represents a novel and different reaction mode. This present transformation involves the ring-opening of methyleneindolinone and the construction of two other new rings simultaneously in an atom-economic manner.

  已经建立了前所未有的异氰酸酯与亚甲基吲哚酮的级联反应，它代表了一种新颖而又不同的反应模式。该当前的转化涉及以原子经济的方式同时打开亚甲基吲哚酮的开环和同时构建另外两个新的环。
• Substrate-controlled product-selectivity in the reaction of the Bestmann–Ohira reagent with N-unprotected isatin-derived olefins
  作者：Ashis Kumar Gupta、Shakir Ahamad、Ekta Gupta、Ruchir Kant、Kishor Mohanan

  DOI：10.1039/c5ob01382h

  日期：——

  A mild and efficient reaction of the Bestmann–Ohira reagent with N-unprotected isatin-derived olefins has been developed for the selective synthesis of spiro-pyrazoline-oxindoles and tricyclic pyrazoles. The reaction features an attractive product-selectivity depending on the substituent on isatin-derived olefin. Treatment of 3-aryl/alkylideneoxindoles with BOR afforded spiropyrazoline-oxindoles, whereas

  已开发出Bestmann–Ohira试剂与N-未保护的异麦芽酮素衍生的烯烃进行温和而有效的反应，以选择性合成螺-吡唑啉-吲哚和三环吡唑。该反应的特征在于诱人的产物选择性，这取决于衍生自直链烯烃的烯烃上的取代基。用BOR处理3-芳基/亚烷基新吲哚类化合物可得到螺并吡唑啉-吲哚类化合物，而3-苯并亚甲基新吲哚类化合物通过独特的扩环反应可提供吡唑并喹唑啉酮类化合物。