3,4-dihydroxybenzaldehyde-N-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazone | 485338-24-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3,4-dihydroxybenzaldehyde-N-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazone
• 英文别名: 3-[(3,4-dihydroxyphenyl)methylidenehydrazinylidene]-1H-indol-2-one
• CAS: 485338-24-7
• 化学式: C₁₅H₁₁N₃O₃
• 分子量: 281.271
• InChiKey: HDMQKADUFHATFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  94.3
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  靛红 在 一水合肼 作用下， 以 甲醇 为溶剂， 反应 3.42h， 生成 3,4-dihydroxybenzaldehyde-N-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazone
  参考文献：
  名称：

  Khan, Khalid Mohammed; Khan, Momin; Ali, Muhammad, Journal of the Chemical Society of Pakistan, 2013, vol. 35, # 3, p. 987 - 993

  摘要：

  DOI：

文献信息

• Khan, Khalid Mohammed; Khan, Momin; Ali, Muhammad, Journal of the Chemical Society of Pakistan, 2013, vol. 35, # 3, p. 987 - 993
  作者：Khan, Khalid Mohammed、Khan, Momin、Ali, Muhammad、Qadir, Muhammad Irfan、Perveen, Shahnaz、Karim, Aneela、Choudhary, Muhammad Iqbal

  DOI：——

  日期：——
• Synthesis of bis-Schiff bases of isatins and their antiglycation activity
  作者：Khalid Mohammed Khan、Momin Khan、Muhammad Ali、Muhammad Taha、Saima Rasheed、Shahnaz Perveen、M. Iqbal Choudhary

  DOI：10.1016/j.bmc.2009.09.028

  日期：2009.11

  Bis-Schiff bases 1-27 have been synthesized and their in vitro antiglycation potential has been evaluated. Compounds 21 (IC50 = 243.95 +/- 4.59 mu M), 20 (IC50 = 257.61 +/- 5.63 mu M), and 7 (IC50 = 291.14 +/- 2.53 mu M) showed an excellent antiglycation activity better than the standard (rutin, IC50 = 294.46 +/- 1.50 mu M). This study has identified a series of potential molecules as antiglycation agents. A structure-activity relationship has been studied, and all the compounds were characterized by spectroscopic techniques. (C) 2009 Elsevier Ltd. All rights reserved.
• Khan, Momin; Khan, Khalid Mohammed; Rahim, Fazal, Journal of the Chemical Society of Pakistan, 2015, vol. 37, # 3, p. 520 - 526
  作者：Khan, Momin、Khan, Khalid Mohammed、Rahim, Fazal、Samreen、Perveen, Shahnaz、Karim, Aneela、Imtiazuddin、Choudhary, Muhammad Iqbal

  DOI：——

  日期：——