5-chloro-2-(4-methylphenyl)indole-3-carboxaldehyde | 104384-28-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-chloro-2-(4-methylphenyl)indole-3-carboxaldehyde
• 英文别名: 5-chloro-2-(p-tolyl)-1H-Indole-3-carbaldehyde；5-chloro-2-(4-methylphenyl)-1H-indole-3-carbaldehyde
• CAS: 104384-28-3
• 化学式: C₁₆H₁₂ClNO
• 分子量: 269.73
• InChiKey: JCUVIGLPGHICGE-UHFFFAOYSA-N

物化性质

• 沸点：
  494.7±45.0 °C(Predicted)
• 密度：
  1.302±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  32.9
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5-chloro-2-(4-methylphenyl)indole-3-carboxaldehyde 、 氨基硫脲 在 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 5.0h， 以61%的产率得到2-((5-chloro-2-(p-tolyl)-1H-indol-3-yl)methylene)hydrazine-1-carbothioamide
  参考文献：
  名称：

  Saundane; Manjunatha, Yarlakatti; Walmik, Prabhaker, Heterocyclic Communications, 2009, vol. 15, # 4, p. 303 - 310

  摘要：

  DOI：

文献信息

• Facile, eco-friendly, one-pot protocol for the synthesis of indole-imidazole derivatives catalyzed by amino acids
  作者：Sadia Naureen、Fatima Ijaz、Areesha Nazeer、Faryal Chaudhry、Munawar Ali Munawar、Misbahul Ain Khan

  DOI：10.1080/00397911.2017.1332766

  日期：2017.8.18

  ABSTRACT An efficient, convenient green approach for the synthesis of indole-based 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles by multicomponent reaction of substituted 2-arylindole-3-carbaldehydes, benzil, substituted anilines, and ammonium acetate using catalytic amino acid (glycine) in ethanol is described. Several amino acids have also been evaluated as organic catalysts for these

  摘要：通过取代 2-芳基吲哚-3-甲醛、苯甲醇、取代苯胺、苯胺、苯胺、苯胺等多组分反应合成吲哚基 2,4,5-三取代和 1,2,4,5-四取代咪唑的一种高效、便捷的绿色方法。描述了在乙醇中使用催化氨基酸（甘氨酸）的乙酸铵。几种氨基酸也被评估为这些反应的有机催化剂。化合物的结构是根据红外、质谱和 1H NMR 光谱数据确定的。温和的反应条件、廉价/经济的试剂和良好的收率表明了这种方法的有用性。图形概要
• Bi-functional complexes and methods for making and using such complexes
  申请人：Gouliaev Alex Haahr

  公开号：US11225655B2

  公开（公告）日：2022-01-18

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

  本发明涉及一种合成双功能复合物的方法，该复合物包括分子部分和识别分子部分的识别寡核苷酸部分。根据本发明的合成方法的一部分优选在一种或多种有机溶剂中进行，此时包含可选保护标签或寡核苷酸标识符的新生双功能复合物与固体支持物相连接，合成方法的另一部分优选在适合于将寡核苷酸标签酶加到溶液中的新生双功能复合物的条件下进行。
• Triarylimidazoles-synthesis of 3-(4,5-diaryl-1H-imidazol-2-yl)-2-phenyl-1H-indole derivatives as potent α-glucosidase inhibitors
  作者：Sadia Naureen、Shazia Noreen、Areesha Nazeer、Muhammad Ashraf、Umber Alam、Munawar Ali Munawar、Misbahul Ain Khan

  DOI：10.1007/s00044-014-1239-y

  日期：2015.4

  A series of new trisubstituted imidazoles-3-(4,5-diaryl-1H-imidazol-2-yl)-2-phenyl-1H-indole derivatives (2a-2u) were synthesized and evaluated for their alpha-glucosidase inhibition. The new compounds showed significant alpha-glucosidase inhibitory activity as compared to the standard inhibitor acrabose. Structures of synthesized compounds were determined using FT-IR, Mass spectrometry, H-1 NMR, C-13 NMR, and elemental analyses.
• BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Nuevolution A/S

  公开号：EP2558577B1

  公开（公告）日：2018-12-12
• BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Gouliaev Alex Haahr

  公开号：US20130281324A1

  公开（公告）日：2013-10-24

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.