十八烷二酰肼 | 101882-87-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 十八烷二酰肼
• 英文名称: octadecanedioic acid dihydrazide
• 英文别名: Octadecandisaeure-dihydrazid；Octadecanedihydrazide
• CAS: 101882-87-5
• 化学式: C₁₈H₃₈N₄O₂
• 分子量: 342.525
• InChiKey: DOJQXPIMYAKBFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  110
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  十八烷二酰肼 在 盐酸 、 sodium nitrite 作用下， 生成 十六烷二异氰酸酯
  参考文献：
  名称：

  Iwakura et al., Nippon Kagaku Zasshi, 1957, vol. 78, p. 1504

  摘要：

  DOI：
• 作为产物：
  描述：

  十八烷二酸二乙酯 在 乙醇 、 一水合肼 作用下， 生成 十八烷二酰肼
  参考文献：
  名称：

  Iwakura et al., Nippon Kagaku Zasshi, 1957, vol. 78, p. 1504

  摘要：

  DOI：

文献信息

• Bioresorbable polymer matrices and methods of making and using the same
  申请人：Royer Garfield

  公开号：US20080069894A1

  公开（公告）日：2008-03-20

  A bioerodible composition for delivery of a bioactive agent is the reaction product of a reaction mixture which includes an oxidized dextran solution, and a mixture of solids containing a dihydrazide, a bioactive agent, and optionally a pH adjusting agent in an amount sufficient to achieve a pH of the reaction mixture of 6 or less. The composition may include a release agent for the controlled release of the bioactive agent from the composition. A bioactive agent may therefore be administered to a body site in need of the same by providing a first aliquot portion of a reaction mixture comprising an oxidized dextran solution, and a second aliquot portion of a reaction mixture comprising a mixture of solids comprised of a dihydrazide, a bioactive agent, and a solid acid which is present in an amount sufficient to achieve a pH of the reaction mixture of 6 or less, mixing the first and second aliquot portions to form the reaction mixture thereof, and thereafter installing the reaction mixture at the body site and allowing a solidified bioerodible drug delivery composition to be formed thereby in situ. The present invention may be provided in the form of a kit comprised of a double syringe which respectively contains the first and second aliquot portions of the reaction mixture so that the same may be mixed just prior to use.

  一种可生物降解的组合物，用于释放生物活性剂，是由反应混合物反应产生的，该混合物包括氧化的右旋糖溶液、一种含有双肼、生物活性剂和可选的pH调节剂的固体混合物，其量足以使反应混合物的pH为6或更低。该组合物可以包括释放剂，以控制从组合物中释放生物活性剂。因此，可以通过提供包括氧化的右旋糖溶液的第一等分部和包括由双肼、生物活性剂和固体酸组成的固体混合物的第二等分部的反应混合物的第一等分部和第二等分部混合来将生物活性剂给予需要该剂量的身体部位，并在该部位安装反应混合物，从而在原位形成固化的可生物降解的药物释放组合物。本发明可以形成一个套件的形式，该套件包括一个双注射器，分别包含反应混合物的第一等分部和第二等分部，以便在使用前混合。
• BIORESORBABLE POLYMER MATRICES AND METHODS OF MAKING AND USING THE SAME
  申请人：ROYER Garfield P.

  公开号：US20110318416A1

  公开（公告）日：2011-12-29

  A bioerodible composition for delivery of a bioactive agent is the reaction product of a reaction mixture which includes an oxidized dextran solution, and a mixture of solids containing a dihydrazide, a bioactive agent, and optionally a pH adjusting agent in an amount sufficient to achieve a pH of the reaction mixture of 6 or less. The composition may include a release agent for the controlled release of the bioactive agent from the composition. A bioactive agent may therefore be administered to a body site in need of the same by providing a first aliquot portion of a reaction mixture comprising an oxidized dextran solution, and a second aliquot portion of a reaction mixture comprising a mixture of solids comprised of a dihydrazide, a bioactive agent, and a solid acid which is present in an amount sufficient to achieve a pH of the reaction mixture of 6 or less, mixing the first and second aliquot portions to form the reaction mixture thereof, and thereafter installing the reaction mixture at the body site and allowing a solidified bioerodible drug delivery composition to be formed thereby in situ. The present invention may be provided in the form of a kit comprised of a double syringe which respectively contains the first and second aliquot portions of the reaction mixture so that the same may be mixed just prior to use.

  用于释放生物活性物质的可生物降解组合物是由反应混合物的反应产物形成的，该反应混合物包括氧化葡聚糖溶液和固体混合物，其中固体混合物包含二肼、生物活性物质和可选的调节pH剂，以使反应混合物的pH为6或以下。该组合物可以包括释放剂，以控制从组合物中释放生物活性物质。因此，可以通过提供含有氧化葡聚糖溶液的第一等量部分反应混合物和含有二肼、生物活性物质和固体酸的固体混合物的第二等量部分反应混合物，将两种混合物混合形成反应混合物，并在体内将反应混合物注入需要生物活性物质的部位，从而形成可生物降解的药物释放组合物。本发明可以作为一个套装提供，包括一个双注射器，分别包含反应混合物的第一和第二等量部分，以便在使用前混合。
• BIORESORABLE POLYMER MATRICES AND METHODS OF MAKING AND USING THE SAME
  申请人：ROYER BIOMEDICAL, INC.

  公开号：US20140248298A1

  公开（公告）日：2014-09-04

  Bioactive agents are delivered to a body site in need of the same by providing a first aliquot portion of a reaction mixture which includes an aldehydic polymer solution, and a second aliquot portion of a reaction which includes a cross-linking hydrazide and a bioactive agent. The first and second aliquot portions may be mixed (e.g., by expelling such portions from respective syringe barrels) to form the reaction mixture thereof. The thus formed reaction mixture may then be installed at the body site whereby the reaction mixture is allowed to solidify in situ within about 1 to 10 minutes into a reaction product comprised of a hydrazide cross-linked oxidized aldehydic polymer matrix with the bioactive agent entrapped therein.

  通过提供包含醛基聚合物溶液的第一小部分反应混合物和包含交联肼和生物活性剂的第二小部分反应混合物，将生物活性剂传递到需要的身体部位。第一小部分和第二小部分反应混合物可以混合（例如通过从各自的注射器桶中排出这些部分）以形成反应混合物。然后可以将形成的反应混合物安装在身体部位，使得反应混合物在大约1到10分钟内允许在原位固化为由肼交联氧化醛基聚合物基质组成的反应产物，并在其中包裹生物活性剂。
• Curable epoxide resin compositions
  申请人：CIBA-GEIGY AG

  公开号：EP0351365A2

  公开（公告）日：1990-01-17

  Curable compositions comprise (A) an epoxide resin (B) as latent curing agent for (A), dicyandiamide or a polycarboxylic acid hydrazide, and (C) as cure accelerator dispersed as a powder in the composition, a Mannich base of a polymeric phenol. The compositions are particularly useful as adhesives and sealants.

  可固化组合物包括 (A) 环氧树脂 (B) 作为 (A) 的潜在固化剂，双氰胺或聚羧酸酰肼，以及 (C) 作为固化促进剂以粉末形式分散在组合物中的聚合苯酚曼尼希碱。 这种组合物尤其可用作粘合剂和密封剂。
• Production of compounds
  申请人：CIBA-GEIGY AG

  公开号：EP0493916A2

  公开（公告）日：1992-07-08

  A process for the production of a material having an increased molecular weight relative to the diepoxide starting material the material being either a hydroxy-terminated or an epoxy-terminated material comprising a) reacting a diepoxide with a dihydroxy compound, in the presence, as catalyst, of a triflate salt of a metal of Group IIA, IIB, IIIA, IIIB, or VIIIA of the Periodic Table of Elements (according to the IUPAC 1970 convention); b) de-activating the triflate salt catalyst; and c) optionally advancing the material produced in step b), with an aromatic diol or phenol.

  一种生产相对于二环氧化物起始材料分子量增大的材料的工艺，该材料为羟基封端材料或环氧封端材料，包括 a) 在元素周期表 IIA、IIB、IIIA、IIIB 或 VIIIA 族金属（根据国际理论化学和应用化学联合会 1970 年公约）的三酸盐作为催化剂存在的情况下，使二环氧化物与二羟基化合物反应； b) 使三late 盐催化剂失活；以及 c) 可选地将步骤 b) 中生产的材料与芳香族二元醇或苯酚混合。