丁二酸,3-羟基-2,2-二甲基-,二乙基酯 | 111479-97-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 中文名称: 丁二酸,3-羟基-2,2-二甲基-,二乙基酯
• 英文名称: diethyl 3,3-dimethyl-2-hydroxybutanedioate
• 英文别名: +/-diethyl 3,3-dimethylmalate；3-hydroxy-2,2-dimethyl-succinic acid diethyl ester；3-Hydroxy-2,2-dimethyl-bernsteinsaeure-diaethylester；3-Hydroxy-2.2-dimethyl-butandisaeure-diaethylester；3.3-Dimethyl-aepfelsaeure-diaethylester；α-Oxy-β-methyl-propan-α.β-dicarbonsaeure-diaethylester；Butanedioic acid, 3-hydroxy-2,2-dimethyl-, diethyl ester；diethyl 3-hydroxy-2,2-dimethylbutanedioate
• CAS: 111479-97-1
• 化学式: C₁₀H₁₈O₅
• 分子量: 218.25
• InChiKey: HXUBKVPHEFDAPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  丁二酸,3-羟基-2,2-二甲基-,二乙基酯 在 potassium carbonate 作用下， 以 乙醇 为溶剂， 反应 72.0h， 生成 4-Butoxy-3-hydroxy-2,2-dimethyl-4-oxobutanoic acid
  参考文献：
  名称：

  新型α，α′，β-三取代β-内酯的合成

  摘要：

  提出了简洁高效的α，α'，β-三取代β-内酯的合成方法。这些新颖的内酯可通过五个步骤轻松获得，并将专门用于阴离子开环聚合。

  DOI：

  10.1016/s0040-4039(02)02435-8
• 作为产物：
  描述：

  2,2-二甲基-3-氧代琥珀酸二乙酯 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 以70%的产率得到丁二酸,3-羟基-2,2-二甲基-,二乙基酯
  参考文献：
  名称：

  新型α，α′，β-三取代β-内酯的合成

  摘要：

  提出了简洁高效的α，α'，β-三取代β-内酯的合成方法。这些新颖的内酯可通过五个步骤轻松获得，并将专门用于阴离子开环聚合。

  DOI：

  10.1016/s0040-4039(02)02435-8

文献信息

• Rassow; Bauer, Journal fur praktische Chemie (Leipzig 1954), 1909, vol. <2> 80, p. 102
  作者：Rassow、Bauer

  DOI：——

  日期：——
• Rassow; Bauer, Chemische Berichte, 1908, vol. 41, p. 965
  作者：Rassow、Bauer

  DOI：——

  日期：——
• The oxygen concentrator is a suitable alternative to oxygen cylinders in Nepal
  作者：Bisharad M. Shrestha、Birendra B. Singh、Madhav P. Gautam、Man B. Chand

  DOI：10.1007/bf03020412

  日期：2002.1

  Purpose: To review the efficacy and reliability of oxygen concentrators used over the last six years in Nepal. The apparatus used was a DeVilbiss(R) oxygen concentrator that provided O-2 for anesthesia supplemented with compressed air to drive a Penlon Manley Multivent Ventilator(R). It remains difficult to supply oxygen in cylinders to peripheral hospitals in Nepal due to lack of proper roads.Methods: We conducted a retrospective analysis of a sample of 378 cases anesthetized at the Bir Hospital and at a private hospital in Kathmandu from April through October 1999. The Bain circuit or its modification was used in adults, and Bain or Ayre's T piece in children. High flows from the oxygen concentrator used with the Bain and Ayre's T circuits were reduced to 2 L(.)min(-1), delivered through the halothane vaporizer, supplemented by room air in the modified Bain circuit. Positive pressure ventilation was provided with an Ambubag, Oxford Inflating Bellows or Penlon Manley Multivent Ventilator. Blood pressure, electrocardiogram, FiO(2) and SpO(2) were monitored in all cases.Results: Surgery included urologic, general surgery, obstetrics and gynecological procedures, neurosurgery and closed mitral valvotomy. Age ranged from six months to 78 yr. The anesthetic time lasted from 45 min to 12 hr. The FiO(2) ranged from 0.5 to 0.6 in the Bain and Ayre's T circuits, and from 0.34 to 0.40 in the modified Bain circuit with a flow of oxygen of 2 L(.)min(-1) from the concentratorConclusion: With regular maintenance and servicing done locally, the oxygen concentrator can be used safely in adults and children. Use of the oxygen concentrator is a suitable alternative to oxygen cylinders in the developing world.
• Preferential formation of five-membered rings in two Claisen cyclisations
  作者：Svante Brandänge、Hans Leijonmarck、Zoran Novacic

  DOI：10.1039/c39920000569

  日期：——

  Alpha-Lithiations of the acetoxy groups of 1 and 2 lead to Claisen cyclisations in which five-membered rings are formed much faster than six-membered rings; this selectivity is opposite to that of aldol condensations.
• Synthesis of novel α,α′,β-trisubstituted β-lactones
  作者：Christel Barbaud、Mohamed Guerrouache、Philippe Guérin

  DOI：10.1016/s0040-4039(02)02435-8

  日期：2002.12

  A concise and efficient synthesis of α,α′,β-trisubstituted β-lactones is presented. These novel lactones are easily obtained in five steps and will be dedicated to anionic ring opening polymerization.

  提出了简洁高效的α，α'，β-三取代β-内酯的合成方法。这些新颖的内酯可通过五个步骤轻松获得，并将专门用于阴离子开环聚合。