dimethyl 2-[[(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carbonyl]amino]propanedioate | 205875-03-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: dimethyl 2-[[(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carbonyl]amino]propanedioate
• CAS: 205875-03-2
• 化学式: C₁₅H₂₄N₂O₇
• 分子量: 344.365
• InChiKey: XQZCPLSZWTYEFE-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  111
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  dimethyl 2-[[(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carbonyl]amino]propanedioate 在 sodium hydroxide 、 甲酸 作用下， 生成 (8aS)-(9CI)-六氢-3-甲氧基吡咯并[1,2-a]吡嗪-1,4-二酮
  参考文献：
  名称：

  Electrogenerated chiral building blocks for diastereoselective amidoalkylation reactions

  摘要：

  已经应用了三种不同的电化学方法来合成用于二分立体选择性氨基烷基化反应的手性构建块。这些方法包括：A. 酰胺和碳酸酯的直接阳极α-甲氧基化；B. α-氨基酸衍生物的阳极甲氧基化脱羧（Hofer-Moest反应）C. 间接NaCl介导的α-氨基酸衍生物的阳极α-甲氧基化。描述了这些构建块在合成手性纯α-氨基酸、二分手性1,2-氨基醇和手性1,3-二胺中的应用。

  DOI：

  10.1051/jcp/1996930575
• 作为产物：
  描述：

  BOC-L-脯氨酸 、 氨基丙二酸二乙酯 在 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 氯仿 为溶剂， 以70%的产率得到dimethyl 2-[[(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carbonyl]amino]propanedioate
  参考文献：
  名称：

  Electrogenerated chiral cationic glycine equivalents — Part 1: The 6-methoxy derivative of cyclo(L-Pro-Gly)

  摘要：

  The cyclic N,O-acetal cyclo(L-Pro-Gly(OMe)OMe (8) has proved to be an effective chiral electrophilic glycine equivalent which is applicable in nucleophilic substitution reactions not only under Broenstedt acid catalysis but also under Lewis acid catalysis with excellent diastereoselectivities. This chiral building block can easily be obtained by electrochemical methoxylative decarboxylation of the cyclic dipeptide 6 generated from L-proline and aminomalonic diester. Thus, enantiomerically pure D-allyl glycine has been generated. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00081-7

文献信息

• Synthesis and Catalytic Activities of (<i>S</i>)-1-formylpyrrolidine-2-carboxylic Acid Derivatives for the Enantioselective Reductions of Both a Ketone and a Ketimine
  作者：Zhenfei Chen、Anjiang Zhang、Lixue Zhang、Jing Zhang、Xinxiang Lei

  DOI：10.3184/030823408x318433

  日期：2008.5

  as chiral organocatalysts in the asymmetric reduction of both ketone 2 and ketimine 3. These organic activators afforded good to moderate enantioselectivities in the asymmetric reductions of both the ketone and the ketimine. Among them, organic activator 6h displayed the best efficiency, affording a 84% yield and 41% ee in the reduction of the ketone and 75% yield and 52% ee in the reduction of the ketimine

  一系列 (S)-1-甲酰基吡咯烷-2-羧酸衍生物 (6a-t) 已被合成并作为手性有机催化剂用于酮 2 和酮亚胺 3 的不对称还原。这些有机活化剂提供了良好到中等的对映选择性酮和酮亚胺的不对称还原。其中，有机活化剂6h显示出最佳的效率，在酮的还原中提供了84％的收率和41％的ee，在酮亚胺的还原中提供了75％的收率和52％的ee。
• Electrogenerated chiral building blocks for diastereoselective amidoalkylation reactions
  作者：P Brungs、K Danielmeier、J Jakobi、C Nothhelfer、A Stahl、A Zietlow、E Steckhan

  DOI：10.1051/jcp/1996930575

  日期：——

  Three different electrochemical methods have been applied for the synthesis of chiral building blocks for diastereoselective amidoalkylation reactions. These are A. the direct anodic α-methoxylation of amides and carbamates; B. anodic methoxylative decarboxylation of α-amino acid derivatives (Hofer-Moest reaction) C. indirect NaCl mediated anodic α-methoxylation of α-amino acid derivatives. The application of these building blocks for the synthesis of enantiomerically pure α-amino acids, dichiral 1,2-amino alcohols and chiral 1,3-diamines is described.

  已经应用了三种不同的电化学方法来合成用于二分立体选择性氨基烷基化反应的手性构建块。这些方法包括：A. 酰胺和碳酸酯的直接阳极α-甲氧基化；B. α-氨基酸衍生物的阳极甲氧基化脱羧（Hofer-Moest反应）C. 间接NaCl介导的α-氨基酸衍生物的阳极α-甲氧基化。描述了这些构建块在合成手性纯α-氨基酸、二分手性1,2-氨基醇和手性1,3-二胺中的应用。
• Electrogenerated chiral cationic glycine equivalents — Part 1: The 6-methoxy derivative of cyclo(L-Pro-Gly)
  作者：Georgios Kardassis、Peter Brungs、Eberhard Steckhan

  DOI：10.1016/s0040-4020(98)00081-7

  日期：1998.4

  The cyclic N,O-acetal cyclo(L-Pro-Gly(OMe)OMe (8) has proved to be an effective chiral electrophilic glycine equivalent which is applicable in nucleophilic substitution reactions not only under Broenstedt acid catalysis but also under Lewis acid catalysis with excellent diastereoselectivities. This chiral building block can easily be obtained by electrochemical methoxylative decarboxylation of the cyclic dipeptide 6 generated from L-proline and aminomalonic diester. Thus, enantiomerically pure D-allyl glycine has been generated. (C) 1998 Elsevier Science Ltd. All rights reserved.