3-hydroxypentanedioic acid monoethyl ester | 475486-72-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 3-hydroxypentanedioic acid monoethyl ester
• 英文别名: monoethyl 3-hydroxypentanedioate；5-Ethoxy-3-hydroxy-5-oxopentanoic acid
• CAS: 475486-72-7
• 化学式: C₇H₁₂O₅
• 分子量: 176.169
• InChiKey: OEJAZOGPPRWZKM-UHFFFAOYSA-N

物化性质

• 沸点：
  363.8±32.0 °C(Predicted)
• 密度：
  1.257±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-hydroxypentanedioic acid monoethyl ester 、 1,4-萘醌 在 ammonium peroxydisulfate 、 silver nitrate 作用下， 以 水 、 乙腈 为溶剂， 以29%的产率得到ethyl 4-(1,4-dioxo-1,4-dihydronaphthalen-2-yl)-3-hydroxybutyrate
  参考文献：
  名称：

  Pyranonaphthoquinone Lactones: A New Class of AKT Selective Kinase Inhibitors Alkylate a Regulatory Loop Cysteine

  摘要：

  The naturally occurring pyranonaphthoquinone (PNQ) antibiotic lactoquinomycin and related aglycones were found to be selective inhibitors of the serine-threonine kinase AKT. A set of synthetic PNQs were prepared and a minimum active feature set and preliminary SAR were determined, PNQ lactones inhibit the proliferation of human tumor cell lines containing constitutively activated AKT and show expected effects on cellular biomarkers. Biochemical data are presented supporting a proposed bioreductive alkylation mechanism of action.

  DOI：

  10.1021/jm900075g

文献信息

• RAPIDLY CURING CYANOACRYLATES AS ADHESIVES
  申请人：Swords Noeleen

  公开号：US20100029978A1

  公开（公告）日：2010-02-04

  The present invention relates to a polymerizable adhesive composition which comprises, at least as one constituent, a cyanacrylate component and which requires a comparitively short time for curing when used on surfaces. The present invention therefore also includes a method for the production of the cyanacrylate component described above, and the cyanacrylate component as such.

  本发明涉及一种聚合粘合剂组成物，至少包括一种氰基丙烯酸酯组分，并在表面使用时需要相对较短的固化时间。因此，本发明还包括上述氰基丙烯酸酯组分的制备方法以及氰基丙烯酸酯组分本身。
• Process for producing isocoumarins and intermediates for the same
  申请人：——

  公开号：US20020147350A1

  公开（公告）日：2002-10-10

  Provided is a process for producing an isocoumarin-3-yl-acetic acid derivative, characterized by reacting a homophthalic acid derivative represented by a formula: 1 (wherein R c , R 2 and R are mainly protecting groups) with a malonic acid derivating represented by a formula: 2 (wherein R is an organic group including a lower alkyl group; R 3 is a protecting group for a carboxyl group; and X is a halogen atom or a —OM group (wherein M is alkaline metal or alkaline earth metal)). According to the above process, various isocoumarin-3-yl-acetic acid derivatives can efficiently be provided.

  本发明提供了一种生产异香豆素-3-基乙酸衍生物的工艺，其特征在于将由式 1 (其中 R c , R 2 和 R 主要是保护基团）与丙二酸衍生物的结合，丙二酸衍生物的代表式为 2 (其中 R 为有机基团，包括低级烷基；R 3 是羧基的保护基团；X 是卤素原子或 -OM 基团（其中 M 是碱金属或碱土金属））。根据上述工艺，可以有效地提供各种异香豆素-3-基乙酸衍生物。
• GAP-FILLING CYANOACRYLATE ADHESIVE
  申请人：Bachon Thomas

  公开号：US20060241226A1

  公开（公告）日：2006-10-26

  Gap-filling cyanoacrylate adhesives containing cyanoacrylate esters and organic halogenated polymers with a K-value of at least 46.

  间隙填充型氰基丙烯酸酯粘合剂，含有氰基丙烯酸酯和 K 值至少为 46 的有机卤化聚合物。
• EP0168480A4
  申请人：——

  公开号：EP0168480A4

  公开（公告）日：1987-10-08
• PROCESS FOR PREPARING OPTICALLY-ACTIVE 4-AMINO-3-HYDROXYBUTYRIC ACID
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：EP0168480A1

  公开（公告）日：1986-01-22