3-(4-甲氧基苯基)-4-甲基-1,2,5-恶二唑 | 10429-47-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 3-(4-甲氧基苯基)-4-甲基-1,2,5-恶二唑
• 中文别名: 1,2,5-噁二唑,3-(4-甲氧苯基)-4-甲基-
• 英文名称: 3-(4-methoxy-phenyl)-4-methyl-furazan
• 英文别名: (4-Methoxy-phenyl)-methyl-furazan；3-<4-Methoxy-phenyl>-4-methyl-furazan；Methyl-(4-methoxy-phenyl)-furazan；3-(4-Methoxyphenyl)-4-methyl-1,2,5-oxadiazole；3-(4-methoxyphenyl)-4-methyl-1,2,5-oxadiazole
• CAS: 10429-47-7
• 化学式: C₁₀H₁₀N₂O₂
• 分子量: 190.202
• InChiKey: WCAAOPSZMXZCBY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  48.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(4-甲氧基苯基)-4-甲基-1,2,5-恶二唑 在 溴 、 溶剂黄146 作用下， 生成 3-(3-bromo-4-methoxy-phenyl)-4-methyl-furazan
  参考文献：
  名称：

  Boeris, Gazzetta Chimica Italiana, 1893, vol. 23 II, p. 191,193

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(4-methoxyphenyl)-1,2-propanedione dioxime 在 sodium hydroxide 作用下， 生成 3-(4-甲氧基苯基)-4-甲基-1,2,5-恶二唑
  参考文献：
  名称：

  Ponzio, Gazzetta Chimica Italiana, 1930, vol. 60, p. 49,76

  摘要：

  DOI：

文献信息

• Furoxan analogues of the histamine H3-receptor antagonist imoproxifan and related furazan derivatives
  作者：Paolo Tosco、Massimo Bertinaria、Antonella Di Stilo、Clara Cena、Giovanni Sorba、Roberta Fruttero、Alberto Gasco

  DOI：10.1016/j.bmc.2005.05.004

  日期：2005.8

  in the pentatomic NO-donor furoxan ring, as well as their structurally related furazan analogues devoid of NO-donating properties, are described. The whole series of products displayed reversible histamine H3-antagonistic activity on guinea-pig ileum. 4-(4-(3-(1H-Imidazol-4-yl)propoxy)phenyl)furoxan-3-carbonitrile 16 was also able to induce partial relaxation when added to the bath after electrical

  描述了一系列化合物的合成和药理学表征，其中存在于吡虫啉中的肟亚结构被约束在五原子NO-供体呋喃环中，以及它们的结构相关呋喃类似物没有NO的提供特性。整个系列的产品对豚鼠回肠均表现出可逆的组胺H3拮抗活性。当在豚鼠回肠电收缩期间将4-（4-（3-（1H-咪唑-4-基）丙氧基）苯基）呋喃喃-3-甲腈16加入浴中时，也能够引起部分松弛。 H3拮抗性质的研究。这种现象似乎取决于NO介导的sGC活化。研究了所有产物的亲脂-亲水平衡。
• N-oxides and related compounds. Part XXXVI. Isomerism in the oxadiazole series
  作者：A. J. Boulton、P. Hadjimihalakis、A. R. Katritzky、A. Majid Hamid

  DOI：10.1039/j39690001901

  日期：——

  The structures of the dimerisation products of p-chlorobenzonitrile oxide have been established. Products derived from anethole by the action of nitrous acid are shown to be the isomeric furoxans and the equilibration of these isomers is described.

  已经建立了对氯苄腈氧化物的二聚产物的结构。通过亚硝酸作用从茴香脑中衍生的产物显示为异构的呋喃烷，并描述了这些异构体的平衡。
• Ponzio; Milone, Gazzetta Chimica Italiana, 1928, vol. 58, p. 850
  作者：Ponzio、Milone

  DOI：——

  日期：——
• Boeris, Gazzetta Chimica Italiana, 1893, vol. 23 II, p. 179,180
  作者：Boeris

  DOI：——

  日期：——
• Immunohistochemical Localization of Interleukin-10 in Human Oral and Pharyngeal Carcinomas
  作者：Stephen W. Chandler、Christopher H. Rassekh、Susan M. Rodman、Barbara S. Ducatman

  DOI：10.1097/00005537-200205000-00008

  日期：2002.5

  AbstractObjectives/Hypothesis Interleukin‐10 (IL‐10) is an immunosuppressive cytokine with numerous, well‐described effects on the human cellular and humoral immune response. The oncogenic potential of IL‐10 has been previously investigated in bronchogenic carcinoma, nasopharyngeal carcinoma, Waldeyer's ring carcinoma, and serum supernatants of patients with squamous cell carcinoma of the head and neck (SCCHN). The purpose of the study was to determine the prevalence and cellular localization of IL‐10 in human SCCHN.Study Design Immunohistochemistry of archival tissues.Methods Paraffin‐embedded archival tissues were retrospectively obtained from 98 patients with oral and pharyngeal squamous cell carcinoma. Using a standard immunohistochemical technique, these specimens were stained with a polyclonal antibody to IL‐10.Results Using these methods, we found specific localization of antigenic IL‐10 to individual tumor cells in 65% of tumors studied. Intensity of staining was significantly, but inversely, related to tumor grade and N stage; there also existed a significant staining predisposition for oral cavity lesions when samples from this site were compared with tissues derived from elsewhere in the pharynx. Furthermore, IL‐10 was not localized to normal epithelial keratinocytes or inflammatory cells at the level of sensitivity achieved by the immunohistochemical methods used in the study.Conclusions The findings demonstrate that IL‐10 can be specifically localized to human oral and pharyngeal cancer cells. These data also suggest an inverse association for both tumor grade and N stage with specific tumor marker staining. Future studies should investigate the role of this cytokine in the pathogenesis of human SCCHN.