3,3a,4,8b-tetrahydro-2H-naphtho[1,2-b]furan-2(9bH)-one | 106989-44-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并呋喃类
• 英文名称: 3,3a,4,8b-tetrahydro-2H-naphtho[1,2-b]furan-2(9bH)-one
• 英文别名: 3a,4,5,9b-tetrahydro-3H-naphtho[1,2-b]furan-2-one；3A,4,5,9b-tetrahydro-3H-naphtho[1,2-b]furan-2-on；2,3,3a,4,5,9b-hexahydronaphtho[1,2-b]-furan-2-one；3a,4,5,9b-tetrahydro-3H-benzo[g][1]benzofuran-2-one
• CAS: 106989-44-0
• 化学式: C₁₂H₁₂O₂
• 分子量: 188.226
• InChiKey: SPIQECUWVNSJAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3,3a,4,8b-tetrahydro-2H-naphtho[1,2-b]furan-2(9bH)-one 在 乙醇 、 硫酸 、 ammonium chloride 、 硝酸 、 溶剂黄146 、 锌 作用下， 生成 5A-hydroxy-3a,5,5a,9b-tetrahydro-3H,4H-naphtho[1,2-b]furan-2,8-dione
  参考文献：
  名称：

  Asahina; Momose, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1944, vol. 64, # 3, p. 153

  摘要：

  DOI：
• 作为产物：
  描述：

  α-Tetralol-β-acetic acid 在 盐酸 作用下， 生成 3,3a,4,8b-tetrahydro-2H-naphtho[1,2-b]furan-2(9bH)-one
  参考文献：
  名称：

  Bergs, Chemische Berichte, 1930, vol. 63, p. 1285,1298

  摘要：

  DOI：

文献信息

• Compounds effective as cerebral schemia treating agents
  申请人：Suntory Limited

  公开号：US05057514A1

  公开（公告）日：1991-10-15

  1. A compound having the formula (I): ##STR1## wherein A is --CH.sub.2 --, --O--, or --S--; R.sup.1 is CH.sub.3 or OCH.sub.3 ; R.sup.2 is hydroxy of carboxy which may be optionally esterized or amidated; R.sup.3 is H or a lower alkyl; and n is 0 or an integer of 1 to 6 or a pharmaceutically acceptable sale thereof.

  一种具有化学式(I)的化合物：##STR1## 其中A为--CH.sub.2 --，--O--或--S--；R.sup.1为CH.sub.3或OCH.sub.3；R.sup.2为可选择酯化或酰胺化的羟基或羧基；R.sup.3为H或低碳烷基；n为0或1至6的整数，或其药用可接受盐。
• TETRAHYDRONAPHTHO[1,2-B]FURAN-2(3H)-ONE DERIVATIVES AND PREPARATION AND USES THEREOF
  申请人：SHANGHAI QINGDONG BIOTECHNOLOGY CO., LTD.

  公开号：US20200199089A1

  公开（公告）日：2020-06-25

  Disclosed are a tetrahydronaphtho[1,2-b]furan-2(3H)-one derivative of formula (I) and a method of making the same, where definitions of R, R 1 and R 2 herein are the same as those in the specification. It has been demonstrated by animal experiments that the tetrahydronaphtho[1,2-b]furan-2(3H)-one derivative can significantly inhibit the adjuvant-induced in Wistar male rats so that it can alleviate the primary and secondary lesions, showing a preventive activity to some extent. Therefore, the tetrahydronaphtho[1,2-b]furan-2(3H)-one derivative provided herein is applicable to the preparation of a drug for preventing/treating rheumatoid arthritis, and has promising clinical applications.

  本文公开了一种式(I)的四氢萘并[1,2-b]呋喃-2(3H)-酮衍生物及其制备方法，其中R、R1和R2的定义与规范中的相同。动物实验表明，四氢萘并[1,2-b]呋喃-2(3H)-酮衍生物能够显著抑制Wistar雄性大鼠中的佐剂诱导，从而减轻初级和次级病变，具有一定的预防作用。因此，本文提供的四氢萘并[1,2-b]呋喃-2(3H)-酮衍生物适用于制备预防/治疗类风湿性关节炎的药物，并具有很好的临床应用前景。
• Compounds effective against cerebral insufficiency
  申请人：SUNTORY LIMITED

  公开号：EP0322248A2

  公开（公告）日：1989-06-28

  Compounds having the formula (I): wherein A is -CH2-, -O-, or -S-; R1 is CH3 or OCH3; R2 is hydroxy or carboxy which may be optionally esterified or amidated; R3 is H or a lower alkyl; and n is 0 or an integer of 1 to 6, and pharmaceutically acceptable salts thereof, are disclosed. The compounds, and pharmaceutical compositions containing them, are used in therapy for cerebral insufficiency.

  具有式(I)的化合物： 其中 A 是-CH2-、-O-或-S-；R1 是 CH3 或 OCH3；R2 是羟基或羧基，可选择酯化或酰胺化；R3 是 H 或低级烷基；n 是 0 或 1 至 6 的整数。这些化合物和含有它们的药物组合物可用于治疗脑功能不全。
• Tetrahydronaphtho[1,2-b]furan-2(3H)-one derivatives and preparation and uses thereof
  申请人：SHANGHAI QINGDONG BIOTECHNOLOGY CO., LTD.

  公开号：US11034663B2

  公开（公告）日：2021-06-15

  Disclosed are a tetrahydronaphtho[1,2-b]furan-2(3H)-one derivative of formula (I) and a method of making the same, where definitions of R, R1 and R2 herein are the same as those in the specification. It has been demonstrated by animal experiments that the tetrahydronaphtho[1,2-b]furan-2(3H)-one derivative can significantly inhibit the adjuvant-induced in Wistar male rats so that it can alleviate the primary and secondary lesions, showing a preventive activity to some extent. Therefore, the tetrahydronaphtho[1,2-b]furan-2(3H)-one derivative provided herein is applicable to the preparation of a drug for preventing/treating rheumatoid arthritis, and has promising clinical applications.

  本发明公开了一种式(I)的四氢萘并[1,2-b]呋喃-2(3H)-酮衍生物及其制造方法，其中R、R1和R2的定义与说明书中的定义相同。动物实验证明，四氢萘并[1,2-b]呋喃-2(3H)-酮衍生物能显著抑制佐剂诱导的 Wistar 雄性大鼠的原发性和继发性病变，在一定程度上显示出预防活性。因此，本文提供的四氢萘并[1,2-b]呋喃-2(3H)-酮衍生物适用于制备预防/治疗类风湿性关节炎的药物，具有良好的临床应用前景。
• A Novel Intermolecular Synthesis of γ-Lactones via Visible-Light Photoredox Catalysis
  作者：Xiao-Jing Wei、Deng-Tao Yang、Lin Wang、Tao Song、Li-Zhu Wu、Qiang Liu

  DOI：10.1021/ol402954t

  日期：2013.12.6

  Direct gamma-lactone formation via visible-light photoredox catalysis has been achieved efficiently including hydroxylalkylation of aromatic alkenes and transesterification. The present photocatalytic protocol has good regioselectivity and substrate compatibility, affording a novel way to intermolecular gamma-lactone synthesis by the reaction of styrenes with alpha-bromo esters in the absence of any external oxidants.