[3′,4′-dihydro-2′(1′H)-isoquinolinyl](1-methyl-1H-indol-3-yl)methanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: [3′,4′-dihydro-2′(1′H)-isoquinolinyl](1-methyl-1H-indol-3-yl)methanone
• 英文别名: 3,4-dihydro-1H-isoquinolin-2-yl-(1-methylindol-3-yl)methanone
• 化学式: C₁₉H₁₈N₂O
• 分子量: 290.365
• InChiKey: BJUMRSZJRKZCBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  25.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-甲基吲哚-3-甲酸 在 modified Mukaiyama reagent 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 0.58h， 生成 [3′,4′-dihydro-2′(1′H)-isoquinolinyl](1-methyl-1H-indol-3-yl)methanone
  参考文献：
  名称：

  Fluorous 2-chloropyridinium salt (Mukaiyama condensation reagent) for amide formation reactions

  摘要：

  A new fluorous 2-chloropyridinium hexafluorophosphate was prepared as a modified Mukaiyama condensation reagent, and it was applied in amide formation reactions. Good to excellent purities of amides were obtained after fluorous solid-phase extraction of reaction mixtures without additional chromatography. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.07.072

文献信息

• Acylative Coupling of Amine and Indole Using Chloroform as a Carbonyl Group
  作者：Yuika Nishida、Norihiko Takeda、Kenji Matsuno、Okiko Miyata、Masafumi Ueda

  DOI：10.1002/ejoc.201800571

  日期：2018.8.7

  Chloroform‐mediated acylative coupling of amines and indoles has been developed. Indoles and amines in chloroform were treated with dimethylzinc in the presence of air, resulting in a three‐component acylative coupling reaction in which in‐situ generation of phosgene produces indole‐3‐carboxamides.

  已开发出氯仿介导的胺和吲哚的酰基偶联。在空气中用二甲基锌处理氯仿中的吲哚和胺，导致三组分酰基偶联反应，在该反应中原位产生的光气会生成吲哚-3-羧酰胺。
• Fluorous 2-chloropyridinium salt (Mukaiyama condensation reagent) for amide formation reactions
  作者：Tadamichi Nagashima、Yimin Lu、Michael J. Petro、Wei Zhang

  DOI：10.1016/j.tetlet.2005.07.072

  日期：2005.9

  A new fluorous 2-chloropyridinium hexafluorophosphate was prepared as a modified Mukaiyama condensation reagent, and it was applied in amide formation reactions. Good to excellent purities of amides were obtained after fluorous solid-phase extraction of reaction mixtures without additional chromatography. (c) 2005 Elsevier Ltd. All rights reserved.